Transient receptor potential ankyrin-1 participates in visceral hyperalgesia following experimental colitis

The role of TRPA1 in visceral inflammation and pain

“…[28][29][30][31] A few years ago, Yang et al demonstrated that reduction of TRPA1 expression by antisense oligodeoxynucleotide significantly reduced colonic hypersensitivity induced by trinitrobenzene-sulphonic acid (TNBS)-mediated colitis in mice. 48 These results were further supported and expanded by a recent study showing that TRPA1 agonists allyl isothiocyanate and trans-cinnamaldehyde induced mechanosensory responses in vagal and pelvic serosal afferents of TRPA1 +/+ mice, but not in TRPA1-deficient animals. 49 These observations were corroborated by in vivo recording of visceromotor responses to colorectal distention, which showed a significant reduction in mechanical hyperalgesia in TRPA -/-mice, therefore directly implicating TRPA1 in colonic pain.…”

Transient Receptor Potential Channels as Drug Targets: From the Science of Basic Research to the Art of Medicine

“…Indeed, ASIC(2/2) mice display a reduction in pain behavior that is similar in magnitude to that observed in the TRPV1 knockouts (Jones et al, 2005a). Furthermore, is has been shown that TRPA1 (presumably present on TRPV1-positive fibers) is markedly upregulated during TNBS-evoked colitis (Yang et al, 2008). Consistent with a pathogenic role of the increased TRPA1 expression, both intrathecal administration of TRPA1 antisense oligodeoxynucleotide (Yang et al, 2008) and intraperitoneal blockade of TRPA1 by the small molecule antagonist TCS-5861528 (Vermeulen et al, 2013) was reported to reverse hyperalgesia to colonic distension.…”

Effects of dietary allicin on health and growth performance of weanling piglets and reduction in attractiveness of faeces to flies

“…Thus, increased surface area of the small intestine, as a positive consequence of allicin and aged garlic extract administration, may be postulated as a factor responsible for improved systemic development as suggested by Tatara et al (2005b). In addition, as TRPA1 appears to play a role in visceral hyperalgesia (Yang et al, 2008), the effect of chronic or subchronic dietary allicin on gastrointestinal pain or comfort is an open question. The improved growth performance and reduced incidence of diarrhoea in piglets in this study may all relate to the effects on this type of underlying signalling mechanism.…”