Transient Tachypnea of the Newborn

Hagen, Eunice; Chu, Alison; Lew, Cheryl D.

doi:10.1542/neo.18-3-e141

Cited by 19 publications

(13 citation statements)

References 28 publications

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“…Historically, TTN has been believed to have a good prognosis with symptoms usually resolving within 48 h [30]; however, more recent studies have detected associations with subsequent asthma and wheeze in childhood [17–19]. To this, our study suggests TTN may also be implicated in an early course of RIH, which resolves by 6 months of age.…”

Section: Discussionmentioning

confidence: 49%

The role of neonatal pulmonary morbidity in the longitudinal patterns of hospitalisation for respiratory infection during the first year of life

2018

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Respiratory infections among infants constitute a major burden to health care systems in developed nations, yet the course and risk factors leading to these conditions are poorly understood. We examine the longitudinal patterns of respiratory infection hospitalisation (RIH) and how these patterns are influenced by neonatal pulmonary morbidities. We included all live births (n = 429 058) occurring in the Australian state of Queensland between January 2009 and December 2015. Data were structured so that each participant had a record (present/absent) of RIH for each month from birth to 12 months. Initially, latent class growth analysis was used to identify the trajectories of RIH adjusted for spatial-temporal factors; using the identified trajectories of RIH as outcomes, we built a multinomial logistic regression model to identify neonatal predictors of RIH trajectories. Our results indicated that a four-class solution was the best fit to the data, comprising a 'no-risk' trajectory, a 'low-risk' trajectory, an 'early-risk' trajectory and a 'chronic-risk' trajectory. Compared with the no-risk trajectory, membership in the other trajectories was predicted by a range of neonatal pulmonary morbidities, with transient tachypnoea of newborn showing a specific relationship with the early-risk group and sleep apnoea showing a specific and strong risk with the chronic-risk group. Our findings suggest the possibility of identifying neonates at risk of recurrent RIH and implementing effective intervention strategies prior to neonatal discharge.

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Section: Discussionmentioning

confidence: 49%

The role of neonatal pulmonary morbidity in the longitudinal patterns of hospitalisation for respiratory infection during the first year of life

2018

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“…1 It is a common respiratory disorder which occurs in neonatal period. 2,3 Data about the exact prevalence of TTN is scarce in Western literature, 4,5 however, the worldwide incidence of TTN in relation to gestational age shows that almost 10% of infants between 33-34 weeks of gestation, 5% of infants at 35-36 weeks and less than 1% of those more than 37 weeks have clinical features suggestive of TTN. 6,7 With the onset of labor in the term or later preterm mother, the fetal lungs begin to clear out fluid.…”

Section: Introductionmentioning

confidence: 99%

“…Drugs studied to be effective in relieving symptoms of TTN include diuretic therapy, inhaled racemic Epinephrine, and inhaled beta 2-agonists, however none of the trials have so far been able to identify a definitive treatment option for this condition. 3 In developing countries like Pakistan, where there are limitation of resources and Neonatal Intensive Care Units (NICUs/nurseries) are overburdened with the number of babies,it is operational necessity to reduce the length of stay. Neonates admitted to NICUs with TTN though generally a benign condition require close observation and supportive treatment for varying periods that might extend up to many days.…”

Section: Introductionmentioning

confidence: 99%

Effects of Salbutamol and Furosemide in The Treatment of Transient Tachypnea of Newborn - A Randomized Controlled Trial

Khushdil

Ahmed

et al. 2022

PAFMJ

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Objective: To assess and compare the effect of Salbutamol and Furosemide therapy in the management of transient tachypnea of newborn. Study Design: Randomized controlled trial (Registered with Clinical Trials.gov: NCT03208894). Place and Duration of Study: Neonatal Intensive Care Unit of Pakistan Emirates Military Hospital Rawalpindi from Oct 2019 to May 2020. Methodology: A total of 100 newborns were included in the study. They were divided into 4 groups. Group-A received nebulized 0.1ml Salbutamol. Group-B was given single intravenous dose of injection Furosemide at the dose of 2mg per kg. Group-C received both IV Furosemide and nebulized Salbutamol. Control group-D received only supportive care. Results: There were 48 male babies and 52 female babies. The average gestational age was 38.8 ± 6.2 weeks and the average birth weight was 2558 ± 620 grams. Administration of both Salbutamol and IV Furosemide together (group-C) showed significant reduction in the mean duration of oxygen dependency compared to control-group (13.40 ± 3.342 vs 83.64 ± 68.546 hours respectively (p<0.001), as well as the need for mechanical ventilation. The mean duration of oxygen dependency in other two groups (A and B) were also reduced compared to control group, but the results were not statistically significant. Conclusion: Salbutamol and Furosemide when given together tend to reduce the duration of oxygen dependency and need for invasive mechanical ventilation in babies with transient tachypnea of newborn.

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“…Infants with this condition typically have increased work of breathing, manifested by nasal flaring, mild intercostal and subcostal retractions, and expiratory grunting [4]. TTNB is a benign self-limited condition that usually resolves within 48-72hours [5], and requires only monitoring and supportive treatment in neonatal intensive care (NICU) [6]. However some doctors use intravenous antibiotics for treatment, based on a terror of hidden infections [7], and because the clinical symptoms are not specific [8].…”

Section: Introductionmentioning

confidence: 99%

Transient Tachypnea of the Newborn and the Use of Prophylactic Antibiotics

Saadoun¹,

Doya²,

Dayoub³

et al. 2021

JDDMC

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Background: Transient tachypnea of the newborn (TTNB) is a common cause of respiratory distress in late preterm and full-term infants. It is caused by a delay in the clearance of fetal lung fluids. Although TTNB is a self-limited condition, prophylactic antibiotics usually administered for 48-72 hours until negative blood culture is reported. Objective: In this study, we aim to identify the relationship between using prophylactic antibiotics and the duration of tachypnea and hospitalization in neonates with TTNB. Materials and Methods: this was a cohort study design included 102 infants with TTNB. The infants were divided into two groups, one received supportive care, and the other received supportive care with intravenous antibiotics. The clinical signs and laboratory results were examined in the two groups. Results: Of total 102 infants who were included in this study, 41 (40.2%) were received supportive care with prophylactic intravenous antibiotics. There were no significant differences between two groups in terms of gender, gestational age, birth weight, mode of delivery, and white blood cell. A significant relation was found between receiving prophylactic antibiotics with the duration of tachypnea and hospitalization. Conclusions: In the recent study, we found an increase in the hospitalization and tachypnea period in the group received antibiotics.

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Transient Tachypnea of the Newborn

Cited by 19 publications

References 28 publications

The role of neonatal pulmonary morbidity in the longitudinal patterns of hospitalisation for respiratory infection during the first year of life

The role of neonatal pulmonary morbidity in the longitudinal patterns of hospitalisation for respiratory infection during the first year of life

Effects of Salbutamol and Furosemide in The Treatment of Transient Tachypnea of Newborn - A Randomized Controlled Trial

Transient Tachypnea of the Newborn and the Use of Prophylactic Antibiotics

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