Transient Testicular Warming Enhances the Suppressive Effect of Testosterone on Spermatogenesis in Adult Cynomolgus Monkeys (Macaca fascicularis)

Lue, Yanhe; Wang, Christina; Liu, Yi‐Xun; Hikim, Amiya P. Sinha; Zhang, Xuesen; Ng, Chiu-Ming; Hu, Zheng-Da; Li, Yin-Chuan; Leung, A. F.; Swerdloff, Ronald S.

doi:10.1210/jc.2005-1808

Cited by 60 publications

(57 citation statements)

References 30 publications

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“…Thermal stress has more recently been associated with decreased semen parameters, including progressive motility [32,33]. In equine research, thermal stress is a debated topic area with no conclusive results [34], suggesting further research into the effect of testicular thermal stress with regards to semen quality and exercise could be completed.…”

Section: Progressive Motilitymentioning

confidence: 99%

A Preliminary Comparison of Semen Quality between Competing and Non-Competing Equine Stallions

Wilson¹,

Twigg-Flesner

2017

J Vet Sci Technol

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Rationale: Artificial insemination allows sport horse stallions within breeding programmes to breed and compete concurrently. The level of exercise of stallions complete during the breeding season is a controversial subject. Daily exercise at low intensities is important for the mental and reproductive well-being of the stallion, however higher intensities of exercise, as seen in competing stallions, may have detrimental effects on seminal quality. The purpose of this study was to gain a greater understanding into the effects of competition and discipline on equid stallion semen through analysis of seminal parameters. The identification of optimal competition management for breeding stallions may lead to increased stallion fertility and economic gain. Methods:This retrospective study evaluated the seminal data of 1130 stallion collections from two UK based stud farms between 2009 and 2015. Seminal volume, concentration and progressive motility were analysed for differences between competing and non-competing stallions, then for differences between stallion disciplines. Results:Competing stallion semen concentration and progressive motility was significantly lower than noncompeting stallions (p<0.05). Semen volume was significantly higher in competing stallions (p<0.05) than noncompeting stallions. Non-competing stallion semen count was significantly higher than that of competing stallions (p<0.05). Conclusion:The difference in semen quality between competing and non-competing stallions, as well as the difference between disciplines suggests endocrinological and physiological changes occur in relation to training intensity and competition. Further research into semen quality considering exercise and competition will allow for contextualisation as to why these differences occurred.

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Section: Progressive Motilitymentioning

confidence: 99%

A Preliminary Comparison of Semen Quality between Competing and Non-Competing Equine Stallions

Wilson¹,

Twigg-Flesner

2017

J Vet Sci Technol

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“…[53][54][55] In Chinese men, injectable testosterone undecanoate (TU) alone or in combination with oral levonorgestrel (LNG) resulted in the relatively slow suppression of spermatogenesis. 56 Thus, this study provides an ideal model with hormone-induced suppression of spermatogenesis.…”

Section: Hormone-induced Suppression Model Of Spermatogenesismentioning

confidence: 99%

Proteomics of spermatogenesis: from protein lists to understanding the regulation of male fertility and infertility

Huang¹,

Sha²

2010

Asian J Androl

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Proteomic technologies have undergone significant development in recent years, which has led to extensive advances in protein research. Currently, proteomic approaches have been applied to many scientific areas, including basic research, various disease and malignant tumour diagnostics, biomarker discovery and other therapeutic applications. In addition, proteomics-driven research articles examining reproductive biology and medicine are becoming increasingly common. The key challenge for this field is to move from lists of identified proteins to obtaining biological information regarding protein function. The present article reviews the available scientific literature related to spermatogenesis. In addition, this study uses two-dimensional electrophoresis mass spectrometry (2DE-MS) and liquid chromatography (LC)-MS to construct a series of proteome profiles describing spermatogenesis. This large-scale identification of proteins provides a rich resource for elucidating the mechanisms underlying male fertility and infertility.

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“…Mild elevations in scrotal temperature, just above that of the body core, can cause germ cell apoptosis (326,327). Rodent germ cells appear to be particularly susceptible to testicular heat (328,329).…”

Section: A Testicular Targetsmentioning

confidence: 99%

Advances in Male Contraception

2008

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Transient Testicular Warming Enhances the Suppressive Effect of Testosterone on Spermatogenesis in Adult Cynomolgus Monkeys (Macaca fascicularis)

Abstract: This proof-of-concept study demonstrates that transient testicular warming enhances and hastens the effect of T implant on the suppression of spermatogenesis in monkeys.

Cited by 60 publications

References 30 publications

A Preliminary Comparison of Semen Quality between Competing and Non-Competing Equine Stallions

A Preliminary Comparison of Semen Quality between Competing and Non-Competing Equine Stallions

Proteomics of spermatogenesis: from protein lists to understanding the regulation of male fertility and infertility

Advances in Male Contraception

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