Transitional Cell Carcinoma of the Renal Pelvis: Experience From 1940 to 1972 and Literature Review

Say, Carlos; Hori, Jose M.

doi:10.1016/s0022-5347(17)59755-4

Cited by 34 publications

(4 citation statements)

References 25 publications

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“…5 In certain regions of the world, and in patients with certain tubulointerstitial nephritides, the incidence of urothelial neoplasms of the renal pelvis and ureter is quite high, with renal pelvic carcinoma accounting for as much as 68% of renal tumors in some series. 4,6 As a result of the general scarcity of these tumors, [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] coupled with the even lower incidence of ureteral urothelial tumors (1% of urothelial neoplasms), 2 a large proportion of published reports incorporate tumors at both sites into single studies. There have been few analyses of renal pelvic urothelial neoplasms recently in the pathology literature.…”

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confidence: 99%

Impact of the 1998 World Health Organization/International Society of Urological Pathology classification system for urothelial neoplasms of the kidney

et al. 2005

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The classification of urothelial neoplasms of the kidney traditionally has been similar to that of urinary bladder tumors. Several years ago, the classification of papillary urothelial neoplasms was revised. The current study focuses on the application of the 1998 World Health Organization (WHO)/International Society of Urological Pathology classification system to 102 renal pelvic urothelial neoplasms and compares it to the 1973 WHO classification scheme. In this study, all tumors were classified as urothelial carcinomas, and the majority (85%) were papillary. Most patients with papillary tumors presented with 'superficial' disease (rpT1). With the 1998 system, most papillary carcinomas were high grade, and were more often invasive as compared to low-grade tumors. Only 34% were low-grade papillary tumors and, of these, most (93%) were noninvasive. With the 1973 system, most papillary tumors were grade 2 or 3, with invasion more common in grade 3 tumors. By 1973 criteria, grade 2 tumors were a heterogeneous group; with 1998 criteria, nearly one-half were high grade and the other half low grade. The grade of papillary urothelial carcinomas with both the 1973 and 1998 grading methods was associated with stage (P ¼ 0.001). Our study reveals that papillomas and papillary urothelial neoplasms of low malignant potential are uncommon tumors in the kidney. Renal pelvic papillary urothelial neoplasms are most often carcinomas and are more commonly high grade than low grade. Although both the 1973 and 1998 systems showed a significant association with tumor stage, grade 2 papillary carcinomas are a heterogeneous group by 1973 criteria. The 1998 system provides useful information in that it more clearly defines a papillary tumor's grade and selects for a group of tumors, namely low-grade papillary urothelial carcinomas, for which a low likelihood of invasion can be predicted.

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Impact of the 1998 World Health Organization/International Society of Urological Pathology classification system for urothelial neoplasms of the kidney

et al. 2005

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“…Most studies have found urothelial tumors of kidney and ureter to be more common in men than in women. 14 In present study majority of patients were males (75%) with male to female ratio of 3:1.…”

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confidence: 45%

Clinico-pathological profile of patients with upper tract TCC: a single centre experience

et al. 2018

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Background: Urothelial carcinomas are rare tumors and this rarity have made these tumors greatly significant. Urothelial Carcinoma of Upper Urinary Tract (UC-UUT) are still rarer and occur in elderly population. Much of the literature concerning urothelial neoplasms has focused on the urinary bladder, which is understandable given that the majority of these tumors occur in the bladder. Most common UC-UUT are the renal pelvic tumors followed by distal ureteric tumors. There is paucity of literature of UC-UUT in the Indian context hence this study assumes importance.Methods: 16 cases of UC-UUT were included in the study. A complete preoperative evaluation was done. Radical Nephroureterectomy (RNU) with bladder cuff excision was undertaken and histopathology of resected specimen was noted. Adjuvant therapy was given wherever necessary. A systematic follow-up was done, and recurrences were noted and treated. Data was then analyzed.Results: Male to female ratio was 3:1. Most patients presented with hematuria. Most lesions were left sided. Renal pelvis was the most affected site.73% tumors were of high grade and 47% were in pT3 stage. There was a single case of systemic metastasis in present study.15 out of 16 cases underwent radical nephroureterectomy with bladder cuff excision. In follow up, recurrence free survival was 66.67% and cancer free survival was 86.6% after surgery.Conclusions: Upper urinary tract urothelial tumor is a rare disease In Indian context, majority of patients presented late and were having high stage and grade at the time of diagnosis. Invasive disease was more common. Radical nephroureterectomy in still the gold standard treatment. Conservative treatment should be considered in specific cases. Recurrences in bladder are common and should be treated early.

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“…Nephroureterectomy with excision of the ipsilateral ureteral orifice and bladder cuff en bloc remains the gold standard treatment of the upper urinary tract urothelial cancers. Due to the high rate of ureteral stump recurrence, which has been reported to be between 30% and 75%, it is important to complete the nephroureterectomy with a cuff of urinary bladder [6][7][8][9][10] .…”

Section: Introductionmentioning

confidence: 99%

Gigantic transitional cell carcinoma of the renal pelvis in the region of endemic nephropathy

et al. 2012

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Transitional Cell Carcinoma of the Renal Pelvis: Experience From 1940 to 1972 and Literature Review

Cited by 34 publications

References 25 publications

Impact of the 1998 World Health Organization/International Society of Urological Pathology classification system for urothelial neoplasms of the kidney

Impact of the 1998 World Health Organization/International Society of Urological Pathology classification system for urothelial neoplasms of the kidney

Clinico-pathological profile of patients with upper tract TCC: a single centre experience

Gigantic transitional cell carcinoma of the renal pelvis in the region of endemic nephropathy

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