Translation and validation of the arabic version of the revised 15‐item myasthenia gravis quality‐of‐life questionnaire

Alanazy, Mohammed H.; Abuzinadah, Ahmad R.; Muayqil, Taim

doi:10.1002/mus.25948

Cited by 9 publications

(16 citation statements)

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“…In conclusion, the MG‐ADL‐A, is reliable, stable, valid, and sensitive to change. The MG‐ADL‐A can be used along with the MGQOL15R‐A to monitor patients with MG whose first language is Arabic during visits to the clinic as well as remotely.…”

Section: Discussionmentioning

confidence: 99%

“…Patients were consecutively recruited from the neuromuscular clinic at KSUMC between July 1, 2017 and August 31, 2018. Most patients had been involved in a previous study of the validation of the MGQOL15R‐A; however, data that were collected for the present study were new. We recruited patients with a confirmed diagnosis of MG who were 18 years of age or older.…”

Section: Methodsmentioning

confidence: 99%

“…The MG‐ADL scale was translated into Arabic by following the same procedure that was previously reported for the translation and cultural adaptation of the MGQOL15R‐A and in accordance with the cross‐cultural adaptation guidelines . In brief, 2 rounds of forward–backward translations were conducted by 3 neurologists and 1 translator.…”

Section: Methodsmentioning

confidence: 99%

“…It is imperative to have commonly used patient‐reported outcome measures of MG available in languages other than English to improve patient care and to facilitate international collaboration in clinical trials. We recently translated and validated an Arabic version of the MGQOL15R (MGQOL15R‐A) . We subsequently collected data to validate an Arabic version of the MG‐ADL and test its psychometric properties.…”

mentioning

confidence: 99%

“…We recently translated and validated an Arabic version of the MGQOL15R (MGQOL15R-A). 7 We subsequently collected data to validate an Arabic version of the MG-ADL and test its psychometric properties.…”

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confidence: 99%

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Translation and validation of the arabic version of the myasthenia gravis activities of daily living scale

2019

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Introduction We translated the myasthenia gravis (MG)‐specific activities of daily living (MG‐ADL) scale into Arabic (MG‐ADL‐A) and assessed its psychometric properties. Methods We assessed reliability using Cronbach's α, reproducibility using the intraclass correlation coefficient, and validity using Spearman's correlations with MG composite (MGC) score, MG‐specific manual muscle test (MG‐MMT), and MG quality‐of‐life revised Arabic version (MGQOL15R‐A). Differences in MG‐ADL‐A scores among patients with different disease severity were evaluated by using the Kruskal–Wallis test. Sensitivity to change was examined by using the Wilcoxon signed‐rank test. Results We recruited 87 patients. The mean MG‐ADL‐A score was 3.38 ± 3.38 (α = 0.77, ICC = 0.99). The correlation coefficients between the MG‐ADL‐A and MGQOL15R‐A, MGC, and MG‐MMT were 0.63, 0.74, and 0.61, respectively (P < 0.001). The MG‐ADL‐A discriminated between different severity groups and was responsive to clinical improvement at follow‐up. Discussion The MG‐ADL‐A has rigorous psychometric properties and can be used with Arabic‐speaking patients with MG. Muscle Nerve 59:583–583, 2019

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Translation and validation of the arabic version of the myasthenia gravis activities of daily living scale

2019

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Severity and depression can impact quality of life in patients with myasthenia gravis

et al. 2019

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Background: The revised 15-item Myasthenia Gravis (MG) Quality of Life Questionnaire (MGQoL15R) is a validated scale of quality of life in patients with MG. We aimed to study the factors causing the variability within the Arabic version of the MGQoL15R (MGQoL15R-A). Method: A standardized questionnaire was completed by 118 patients. Correlations and hierarchical regression analyses were used to assess the contribution of sociodemographic variables, clinical factors, Patient Health Questionnaire-9 (PHQ9-A), and Generalized Anxiety Disorder-7 (GAD7-A) to the variability in the MGQoL15R-A. Results: The MGQoL15R-A was highly correlated with PHQ9-A (r = 0.76), and moderately correlated with GAD7-A (r = 0.52). Clinical factors and PHQ9-A independently explained 30.4% and 34.5% of the variability, respectively. Among the clinical factors, uncontrolled MG status, relapse within the past year, and a higher number of current MG therapies were significantly associated with a higher MGQoL15R-A score.Conclusions: MG severity and depressive symptoms (measured by PHQ9-A) can affect the MGQoL15R-A score.

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Utilization of MG‐ADL in myasthenia gravis clinical research and care

Muppidi

Silvestri

Tan³

et al. 2022

Muscle and Nerve

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The Myasthenia Gravis Activities of Living (MG‐ADL) scale is an 8‐item patient‐reported scale that measures myasthenia gravis (MG) symptoms and functional status. The objective of the current review is to summarize the psychometric properties of the MG‐ADL and published evidence of MG‐ADL use. A targeted literature review for published studies of the MG‐ADL was conducted using a database and gray literature search. A total of 48 publications and 35 clinical trials were included. Studies indicated that the MG‐ADL is a reliable and valid measure that has been used as an outcome in clinical trials and observational studies to measure MG symptoms and response to treatment. While most often used as a secondary endpoint in clinical trials, its use as a primary endpoint has increased in recent years. The most common MG‐ADL endpoint is change in MG‐ADL score from baseline, although there has been an increase in the analysis of a responder threshold using the MG‐ADL. A new concept of minimal symptom expression (MSE) has emerged more recently. Duration of treatment effect is another important construct that is being increasingly evaluated using the MG‐ADL. The use of the MG‐ADL as a primary endpoint in clinical trials and in responder threshold analyses to indicate treatment improvement has increased in recent years. MSE using the MG‐ADL shows promise in helping to determine success of treatment and may be the aspirational goal of MG treatment for the future once validated, particularly given the evolving treatment landscape in MG.

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Translation and validation of the arabic version of the revised 15‐item myasthenia gravis quality‐of‐life questionnaire

Abstract: The Arabic version of MGQOL15R is valid, reliable, stable, and sensitive to changes. Muscle Nerve 57: 581-585, 2018.

Cited by 9 publications

References 20 publications

Translation and validation of the arabic version of the myasthenia gravis activities of daily living scale

Translation and validation of the arabic version of the myasthenia gravis activities of daily living scale

Severity and depression can impact quality of life in patients with myasthenia gravis

Utilization of MG‐ADL in myasthenia gravis clinical research and care

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