2002
DOI: 10.1016/s0168-9525(02)02792-0
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Translational repressors in Drosophila

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Cited by 18 publications
(14 citation statements)
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“…Translational regulation often involves specific RNA binding proteins that recognize sequence elements in the 59 leader or 39 untranslated region (Dean et al, 2002). Typically, these proteins communicate with the translation initiation machinery via the eIF4 cap binding complex.…”
Section: Eif3h May Function As a Translational Regulatormentioning
confidence: 99%
“…Translational regulation often involves specific RNA binding proteins that recognize sequence elements in the 59 leader or 39 untranslated region (Dean et al, 2002). Typically, these proteins communicate with the translation initiation machinery via the eIF4 cap binding complex.…”
Section: Eif3h May Function As a Translational Regulatormentioning
confidence: 99%
“…The posterior determinant, the Nanos (Nos) protein (44), together with other proteins binds the maternal hunchback (hb) mRNA, repressing its translation and limiting the expression of Hb protein to the anterior part of the embryo (45,46). Nanos and its partners induce deadenylation of the hb message (47,48).…”
mentioning
confidence: 99%
“…Nanos and its partners induce deadenylation of the hb message (47,48). Deadenylation contributes to but is not essential for translational repression of hb (46,49). Nos itself is also subject to translation regulation; a small fraction of nos RNA is localized to the posterior pole of the embryo, and it is only here that the RNA is translated.…”
mentioning
confidence: 99%
“…Both screens revealed a role for pumilio, a previously identified protein that repressed the expression of Hunchback mRNA in posterior structures during Drosophila embryogenesis (Zamore et al, 1997). Pumilio binds to a specific motif in the 3Ј-UTR termed the nanos response element and is thought to anchor a complex that includes nanos and brat (Dean et al, 2002). In addition to being implicated in learning and memory (Dubnau et al, 2003), pumilio (and nanos) also play a role in shaping dendritic morphology of specific neurons in the Drosophila (Ye et al, 2004).…”
Section: Control By Repressionmentioning
confidence: 99%