Translationally controlled tumour protein: A protein necessary for potyvirus intracellular multiplication that supports plant infection by unrelated viruses

Bruckner, Fernanda Prieto; Andrade, Patrícia Oliveira de; Cascardo, Renan de Souza; Laliberté, Jean‐François; Alfenas‐Zerbini, Poliane

doi:10.1111/aab.12708

Cited by 3 publications

(2 citation statements)

References 62 publications

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“…Therefore, it is necessary to identify new dominant or recessive resistance genes in the common bean and related legumes. For instance, the translationally controlled tumor protein (TCTP) is required for the proliferation of several potyviruses [168,169]. Therefore, the counterpart in the common bean may also be a suitable candidate for resisting BCMV and BCMNV.…”

Section: Future Prospectsmentioning

confidence: 99%

Bean Common Mosaic Disease: Etiology, Resistance Resource, and Future Prospects

Tang

Feng

2022

Agronomy

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Bean common mosaic disease is one of the most destructive diseases of the common bean, which is one of the most important legumes worldwide. It is caused by two closely related potyviruses: bean common mosaic virus (BCMV) and bean common mosaic necrosis virus (BCMNV). Both viruses have spread to all the common bean-growing areas worldwide and have become a major challenge in bean production. In this review, we summarized the biology and diversity of BCMV and BCMNV, discussed the current knowledge on the resistance genes of BCMV, and finally pointed out the future prospects for the control of bean common mosaic disease.

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Section: Future Prospectsmentioning

confidence: 99%

Bean Common Mosaic Disease: Etiology, Resistance Resource, and Future Prospects

Tang

Feng

2022

Agronomy

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“…The potential diversity of the host genes that encode susceptibility factors in plant-potyvirus interactions is enormous. The ability to promote potyviral infection was shown for numerous cellular proteins, from enzymes (Beffa et al, 1996;Ouibrahim et al, 2014;Poque et al, 2015) and carrier proteins (Park et al, 2017;Wu et al, 2020;Soler-Garzoń et al, 2021a) to transcription factors (Endres et al, 2010;Soler-Garzoń et al, 2021b), as well as many other proteins with diverse functions (Hofius et al, 2007;Castellóet al, 2010;Hafreń et al, 2010;Zhu et al, 2014;De et al, 2020;Bruckner et al, 2022;Zuo et al, 2022). However, the study of the genes that confer natural recessive resistance to potyviruses in various crop plants revealed that the molecular basis of this resistance is surprisingly similar in most cases.…”

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confidence: 99%

Plant eIF4E isoforms as factors of susceptibility and resistance to potyviruses

Zlobin

Taranov

2023

Front. Plant Sci.

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Potyviruses are the largest group of plant-infecting RNA viruses that affect a wide range of crop plants. Plant resistance genes against potyviruses are often recessive and encode translation initiation factors eIF4E. The inability of potyviruses to use plant eIF4E factors leads to the development of resistance through a loss-of-susceptibility mechanism. Plants have a small family of eIF4E genes that encode several isoforms with distinct but overlapping functions in cell metabolism. Potyviruses use distinct eIF4E isoforms as susceptibility factors in different plants. The role of different members of the plant eIF4E family in the interaction with a given potyvirus could differ drastically. An interplay exists between different members of the eIF4E family in the context of plant–potyvirus interactions, allowing different eIF4E isoforms to modulate each other’s availability as susceptibility factors for the virus. In this review, possible molecular mechanisms underlying this interaction are discussed, and approaches to identify the eIF4E isoform that plays a major role in the plant–potyvirus interaction are suggested. The final section of the review discusses how knowledge about the interaction between different eIF4E isoforms can be used to develop plants with durable resistance to potyviruses.

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Potato virus Y viral protein 6K1 inhibits the interaction between defense proteins during virus infection

Fang,

Geng,

Wei

et al. 2023

Plant Physiology

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14-3-3 proteins play vital roles in plant defense against various pathogen invasions. To date, how 14-3-3 affects virus infections in plants remains largely unclear. In this study, we found that Nicotiana benthamiana 14-3-3 h interacts with TRANSLATIONALLY CONTROLLED TUMOR PROTEIN (TCTP), a susceptibility factor of potato virus Y (PVY). Silencing of Nb14-3-3 h facilitates PVY accumulation, whereas over-expression of Nb14-3-3 h inhibits PVY replication. The antiviral activities of three Nb14-3-3 h dimerization defective mutants are significantly decreased, indicating that dimerization of Nb14-3-3 h is indispensable for restricting PVY infection. Our results also showed that the mutant Nb14-3-3hE16A, which is capable of dimerizing but not interacting with NbTCTP, has reduced anti-PVY activity; the mutant NbTCTPI65A, which is unable to interact with Nb14-3-3 h, facilitates PVY replication compared to the wild-type NbTCTP, indicating that dimeric Nb14-3-3 h restricts PVY infection by interacting with NbTCTP and preventing its pro-viral function. As a counter-defense, PVY 6K1 interferes with the interaction between Nb14-3-3 h and NbTCTP by competitively binding to Nb14-3-3 h and rescues NbTCTP to promote PVY infection. Our results provide insights into the arms race between plants and potyviruses.

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Translationally controlled tumour protein: A protein necessary for potyvirus intracellular multiplication that supports plant infection by unrelated viruses

Cited by 3 publications

References 62 publications

Bean Common Mosaic Disease: Etiology, Resistance Resource, and Future Prospects

Bean Common Mosaic Disease: Etiology, Resistance Resource, and Future Prospects

Plant eIF4E isoforms as factors of susceptibility and resistance to potyviruses

Potato virus Y viral protein 6K1 inhibits the interaction between defense proteins during virus infection

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