2001
DOI: 10.1016/s0142-9612(01)00027-8
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Transmission electron microscopy of intracellular particles of polyethylene from joint replacement prostheses: size distribution and cellular response

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Cited by 27 publications
(17 citation statements)
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“…Benz et al performed a transmission electron microscopy study of peri-implant tissues retrieved at revision arthroplasty and determined the size distribution of intracellular polyethylene particles [2]. Using electron microscopy they found that the mean length of the intracellular particles varied from 0.4 to 1.0 km.…”
Section: Discussionmentioning
confidence: 99%
“…Benz et al performed a transmission electron microscopy study of peri-implant tissues retrieved at revision arthroplasty and determined the size distribution of intracellular polyethylene particles [2]. Using electron microscopy they found that the mean length of the intracellular particles varied from 0.4 to 1.0 km.…”
Section: Discussionmentioning
confidence: 99%
“…The behaviour of alumina particles mirrored the range of particle number. A close interaction between cells and particle size may be reasonably suggested since very small particles are able to cause more injury to cells has already been shown in vitro and in vivo [22].…”
Section: Discussionmentioning
confidence: 85%
“…A close interaction between cells and particle size may be reasonably suggested, since it has been shown in vitro and in vivo that very small particles are able to cause more injury to cells. 35 It is worth noting that Saos-2 cultures challenged with up to 1 mg/mL particle dose of ALUSI 1 and 2 were able to form mineral nodules after 21 days of testing. 34 Such maintenance of osteoblast phenotype and functions in presence of biomaterials is fundamental: if the activity of osteoblasts is adversely influenced, the rate of bone apposition at the interface will decrease, with negative consequence for implant integration.…”
Section: Discussionmentioning
confidence: 97%