Transport Disc Distraction Osteogenesis for the Reconstruction of a Calvarial Defect

Abstract

Transport disc distraction osteogenesis can induce new bone formation with hardness comparable to that of a normal bone. However, the amount of regenerated bone is not sufficient to allow TDDO to be substituted for conventional autogenous bone grafts.

Transport Distraction Osteogenesis With Recombinant Human Bone Morphogenic Protein-2 for Large Calvarial Defect Reconstruction

“…In previous reports, the size ratio of the transport disc to calvarial defect ranged from 19% to 50%. [1][2][3][4][5][6][7][8][9][10] In this study, we designed the transport disc size for a ratio of 18%, smaller than any previous study ( Table 3). The length of our transport disc was 8 mm, which was the smallest size that permitted fixation to the distraction device.…”

“…There is some evidence to suggest it might result in increased bone regeneration. 6,7 The last factor we believe to be important for TDO success is the use of humoral factors to facilitate or accelerate bone regeneration. DO with BMP treatment is one of the most well-known regimens capable of improving the results of bony regeneration.…”

“…[1][2][3][4][5][6][7][8][9][10] One possible reason which makes this procedure not being widely used until now is the inconsistency of the results. Some studies reported TDO was effective for calvarial reconstruction.…”

“…1,5,8 However, there was also a report that the volume of newly generated bone was not sufficient by this method. 6 Another remarkable point is wide variability of the results. Even in the study that TDO had favorable effect on the treatment of cranial defect, one subject in the control group healed completely without DO, while the other 3 control animals showed no appreciable degree of healing.…”

“…5 In another study using TDO for calvarial defect, wide variability of bone regeneration was also reported from 24% to 96% in TDO group and from 13% to 80% in control group. 6 To promote bone regeneration by TDO, Yun et al used internal type of distraction device. Even in their study, bone formation from 26% to 97% in TDO group and from 0 to 82.9% in control group was reported.…”