The paper aims to demonstrate the possible impacts after the announcement of the exit of the United States of America from the Transpacific Partnership Agreement (TPP), mainly for Brazil. In view of the above, we work with the hypothesis that the consolidation of TPP can bring great negative impacts to Brazil, since it is out of the agreement and also of most megarregional initiatives. To achieve this, the character work exploratory, uses bibliographical and documentary research from records available in newspapers, articles, magazines, books, films and legal documents. The study shows that the exit of the US from the TPP can positively affect the Brazilian economy, considering mainly the agribusiness sector. Therefore, it is necessary that the country adopts a more proactive international policy that allows to leave the supporting role in the great global economic negotiations.