Traumatic Brain Injury Imaging in the Second Near‐Infrared Window with a Molecular Fluorophore

Abstract

ToC figure Traumatic brain injury (TBI) is a leading cause of death and disability worldwide, therefore important to understanding pathogenesis. Here, we designed a bright, renal-excreted and biocompatible near infrared II molecular fluorophore for in vivo imaging of TBI. We observed a transient hypoperfusion in the injured cerebral region, followed by fluorophore leakage. NIR-II fluorophores can provide a non-invasive assessment to TBI.

Molecular imaging of biological systems with a clickable dye in the broad 800- to 1,700-nm near-infrared window

“…We demonstrated the first multicolor biological imaging in the extended 800-to 1,700-nm NIR window in 2D as well as in 3D in a layer-by-layer manner through biological tissues. chain can improve the solubility of the molecular dye compared with the 3,4-ethylenedioxy thiophene donor developed previously (32). Furthermore, dialkyl chain-substituted fluorene units were used as the shielding units, because the stretched dialkyl chains out of the conjugated backbone plane could efficiently prevent parallel intermolecular interactions.…”

Novel bright-emission small-molecule NIR-II fluorophores for in vivo tumor imaging and image-guided surgery

“…At longer fluorescence emission wavelengths in the NIR-II region, the increased bandgap of molecular fluorophores generally gives way to reduce interactions between the conjugated backbone and other molecules, causing a high fluorescence quantum yield (QY). 18,19,20 Therefore, in this work, R 1 substituent groups on the sp 3 carbon of the fluorene group are out-of-plane of the π-conjugated system and thus prevent intermolecular stacking that leads to fluorescence quenching. Meanwhile, newly introduced 2-amino 9,9-dialkyl-substituted fluorene moieties distort the BBTD backbone and thus effectively tune the electrostatic potential distribution and the bandgap to the desired range.…”

Construction of a photothermal Venus flytrap from conductive polymer bimorphs

“…44,45 Because of the large absorption, the PP-PEDOT surface was heated upon exposure to a NIR light, as shown in the thermal image in Figure 2c. The maximum temperature (T max ) of the PP-PEDOT surface on a PDMS (t 1 = 70 μm) was 96, 117 and 131°C, for t 2 of 130, 290 and 400 nm, respectively, upon exposure to a 198 mW NIR source for 10 s (Figure 2b and c).…”