Treatment, comorbidity and survival in stage III laryngeal cancer

Connor, Katie; Pattle, Samuel; Kerr, G.R.; Junor, Elizabeth

doi:10.1002/hed.23653

Cited by 11 publications

(19 citation statements)

References 31 publications

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“…A bias towards non‐surgical treatment for cancer patients with higher levels of comorbidity severity was observed in studies involving patients with different cancers . For example, Connor et al observed that among patients with Stage III laryngeal cancer, those with more comorbid ailments were more likely to receive non‐surgical treatment. McCulloch et al observed the same relationship between increased severity of comorbidity and increased use of non‐surgical treatments among patient with gastric and esophageal cancer patients, and Tetsche et al observed similar findings among patients with ovarian cancer.…”

Section: Importance Of Comorbidity In Surgical Oncologymentioning

confidence: 99%

Assessment of comorbidities in surgical oncology outcomes

Sinha

Kallogjeri

Piccirillo

2014

Journal of Surgical Oncology

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The impact of comorbidities on treatment, postoperative complications, survival, prognosis, and quality of life, makes comorbidities' assessment essential in surgically managed cancer patients. Multiple indices exist to measure the presence and severity of comorbidities, of which the Charlson Comorbidity Index and the Adult Comorbidity Evaluation-27 are the most widely employed. Incorporation of comorbidity data in cancer registries facilitates surgical oncology research conduct with an objective to improve cancer care through better-informed patient counseling and treatment planning.

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Section: Importance Of Comorbidity In Surgical Oncologymentioning

confidence: 99%

Assessment of comorbidities in surgical oncology outcomes

Sinha

Kallogjeri

Piccirillo

2014

Journal of Surgical Oncology

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“…The majority of laryngeal cancers are laryngeal squamous cell carcinomas (LSCC). Despite improvements in diagnostic and therapeutic modalities, there has been no significant improvement in laryngeal cancer survival over the past 20 years [ 2 , 3 ]. Therefore, new diagnostic and therapeutic targets for LSCC are urgently needed.…”

Section: Introductionmentioning

confidence: 99%

Effect of DACH1 on proliferation and invasion of laryngeal squamous cell carcinoma

et al. 2018

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BackgroundTo investigate the effect of DACH1 over-expression on proliferation and invasion of laryngeal squamous cell carcinoma (LSCC).MethodsThe 120 cases of LSCC tumors and 114 adjacent non-neoplastic tissues were collected to detect the expression of DACH1 by immunohistochemistry. The changes of DACH1 expression from each group were assessed and correlated to the clinical parameters of the patients. Plasmid-DACH1 was transfected into Hep-2 cells to up-regulate the expression of DACH1C. Real-time PCR, Western blot, CCK8 and transwell assay were used to verify the cell proliferation and invasion after plasmid-DACH1 transfection.ResultsThe results indicated that DACH1 was downregulated in LSCC tissues as compared to corresponding adjacent non-neoplastic tissues. Decreased expression of DACH1 was found in the tumors upraglottic tumor, lymph node metastases, T3–4 stage and advanced clinical stage. In Hep-2 cells, transfection with plasmid-DACH1 could suppress cell proliferation, invasion and induce G1 phase extension in cell cycle.ConclusionsDACH1 may act as a tumor suppressor gene and could be a potential target for therapeutic intervention of LSCC.

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“…30 Other studies have also reported decreased rates of overall survival in patients with laryngeal carcinoma, attributed to the shift away from surgical approaches. 11,31 In this current series, there were insufficient patients with concurrent chemoradiotherapy to evaluate separately, and therefore a comparative comment cannot be made.…”

Section: Discussionmentioning

confidence: 92%

“…have demonstrated high rates of laryngeal preservation in randomised studies of non-surgical intervention for patients with glottic and supraglottic laryngeal carcinoma (particularly using concurrent chemoradiotherapy), higher rates of non-cancer deaths were also noted 30 . Other studies have also reported decreased rates of overall survival in patients with laryngeal carcinoma, attributed to the shift away from surgical approaches 11 , 31 . In this current series, there were insufficient patients with concurrent chemoradiotherapy to evaluate separately, and therefore a comparative comment cannot be made.…”

Section: Discussionmentioning

confidence: 99%