Treatment of a Case of Mycosis Fungoides and One of Parapsoriasis <i>en Plaque</i> with Topical PUVA Using a Monofunctional Furocoumarin Derivative, 4,6,4'‐Trimethylangelicin

Morita, Akimichi; Takashima, Akira; Nagai, Morihito; Dall’Acqua, Francesco

doi:10.1111/j.1346-8138.1990.tb01692.x

Cited by 13 publications

(7 citation statements)

References 18 publications

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“…SPP may be treated with emollients, topical tar preparations, topical corticosteroids and/or PUVA therapy. Response to therapy is variable 1–7 …”

Section: Discussionmentioning

confidence: 99%

“…Classification of these disorders is controversial and the current generally accepted classification includes three entities: large‐plaque parapsoriasis (LPP), small‐plaque parapsoriasis (SPP) and pityriasis lichenoides 1 . Treatment of LPP, SPP and mycosis fungoides (MF) for many years have consisted of broadband UVB (BB‐UVB) phototherapy 2 as well as psoralen‐UVA therapy (PUVA) 3–9 . Although about 10–30% of cases of LPP result in early form MF, the relation of SPP with MF is still a matter of discussion 10–13 .…”

Section: Introductionmentioning

confidence: 99%

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Narrowband UVB phototherapy for small plaque parapsoriasis

Aydoğan¹,

Karadogan²,

Tunali³

et al. 2006

Acad Dermatol Venereol

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“…SPP may be treated with emollients, topical tar preparations, topical corticosteroids and/or PUVA therapy. Response to therapy is variable 1–7 …”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Narrowband UVB phototherapy for small plaque parapsoriasis

Aydoğan¹,

Karadogan²,

Tunali³

et al. 2006

Acad Dermatol Venereol

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“…The MA and MTA under study (see Scheme 1) were synthesized as in previous works (5,6). The solvents benzene (Baker, UV grade), cyclohexane (Fluka, UV grade), 1,4-dioxane (Aldrich, 99+%) and ethanol (Carlo Erba, RS grade) were used as received, while acetonitrile (Carlo Erba, RPE) was purified by distillation over P,O, before use.…”

Section: Methodsmentioning

confidence: 99%

“…The incapacity to photoinduce these lesions in macromolecules, in vitro and in vivo, explains the lower genotoxicity of angelicins. For this reason, they have been used in the treatment of hyperproliferative skin diseases (psoriasis), as well as for mycosis fungoides (4,5).…”

mentioning

confidence: 99%

Photophysical Behavior of Angelicins and Thioangelicins: Semiempirical Calculations and Experimental Study

et al. 1998

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The decay processes of the lowest excited singlet and triplet states of five methylated angelicins (4,6,4'-trimethylangelicin, MA, and four methylated thioangelicins, MTA; see Scheme 1) were investigated in five solvents by stationary and pulsed fluorometric and flash photolytic techniques. In particular, the solvent effects on absorption, fluorescence, quantum yields of fluorescence (+F) and triplet formation (&), lifetimes of fluorescence ( T~) and the triplet state ( T~) and the quantum yields of singlet oxygen production (+,J were investigated. Semiempirical (ZINDOK-CI) calculations were carried out to obtain information (transition probabilities and nature) on the lowest excited singlet and triplet states. The quantum mechanical calculations and the solvent effect on the photophysical properties showed that the lowest excited singlet state (S,) is a partially allowed n,n* state, while the close-lying S2 state is n,n* in nature. The efficiencies of fluorescence, S, + TI intersystem crossing (ISC) and S1 + So internal conversion (IC) strongly depend on the energy gap between S1 and S2 and are explained in terms of the so-called proximity effect. In fact, for MA in cyclohexane, only the S1 + So internal conversion is operthrough S, -+ So IC only, while in acetonitrile and ethanol, fluorescence and ISC increase significantly. For these compounds there is strong evidence that a '(n,.rr*) state lies just

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“…In microorganisms and mammalian cells TMA shows a high antiproliferative effect and reduced genotoxicity in comparison with 8-MOP (20). In limited clinical studies (20)(21)(22) using topically applied TMA and UVA, it was demonstrated that it had therapeutic activity.…”

Section: Discussionmentioning

confidence: 99%

The Lack of Efficacy of 4,6,4′‐Trimethylangelicin to Induce Immune Suppression in an Animal Model for Photopheresis: a Comparison with 8‐MOP

Iperen

Brun

Caffieri

et al. 1996

Photochem & Photobiology

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Photopheresis is an extracorporeal form of photochemotherapy with 8-methoxypsoralen (8-MOP) and UVA (PUVA). Patients ingest 8-MOP and then a psoralen-rich buffy coat is obtained by centrifugation and mixed with saline. This mixture is recirculated through a UVA radiation field and then reinfused. Photopheresis appears to be effective for several T cell-mediated disorders, because the treatment results in a specific immune response against the pathogenic clone of T cells involved. With PUVA therapy, the whole body of the patient is exposed to UVA, after ingestion of 8-MOP. Upon UVA exposure 8-MOP binds to, amongst others, DNA and induces DNA monoadducts and interstrand cross-links. As a result of these photoadducts photocarcinogenicity is a risk in PUVA. In PUVA for psoriasis, it proved that angular furocoumarins, although almost incapable of inducing DNA cross-links (less carcinogenic), are still effective. In order to determine if monoadducts induced by photopheresis could also be effective we used, specifically, 4,6,4'-trimethylangelicin (TMA). In this report, we compare the photodegradation of both TMA and 8-MOP under conditions relevant to the in vivo situation, as well as the effect both compounds have on the viability of rat lymphocytes as measured with the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. We show that TMA did not induce immunosuppression in vivo, even after extensive irradiation. In addition a dose dependency of 8-MOP/UVA versus the induced immune suppression was carried out. It was shown that there is a log dose/response correlation of r=0.9205.

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Treatment of a Case of Mycosis Fungoides and One of Parapsoriasis en Plaque with Topical PUVA Using a Monofunctional Furocoumarin Derivative, 4,6,4'‐Trimethylangelicin

Cited by 13 publications

References 18 publications

Narrowband UVB phototherapy for small plaque parapsoriasis

Narrowband UVB phototherapy for small plaque parapsoriasis

Photophysical Behavior of Angelicins and Thioangelicins: Semiempirical Calculations and Experimental Study

The Lack of Efficacy of 4,6,4′‐Trimethylangelicin to Induce Immune Suppression in an Animal Model for Photopheresis: a Comparison with 8‐MOP

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