Treatment of atrophic acne scars using autologous platelet‐rich plasma vs combined subcision and autologous platelet‐rich plasma: A split‐face comparative study

Hassan, Akmal S.; El‐Hawary, Marwa Safwat; Raheem, Heba M. Abdel; Abdallah, Samar Hassan; El-Komy, Mohamed H.M.

doi:10.1111/jocd.13048

Cited by 13 publications

(15 citation statements)

References 20 publications

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“…Abeer A Hodeib (Gentile & Garcovich, 2020) 1 1 1 1 1 1 1 1 0 1 3 1 1 1 3 1 1 1 1 1 1 1 1 0 1 3 0 21 Zeinab A. Ibrahim (Hassan et al, 2020) 1 1 1 1 0 1 1 1 1 1 3 1 1 0 0 1 1 1 1 1 1 1 1 0 0 1 2 22 N Agamia (Nicoli et al, 2015) 1 1 1 1 0 1 0 1 0 1 3 1 1 1 0 1 1 1 1 1 1 1 1 1 0 3 1 20 Eman Nofal (Giordano et al, 2017) 1 1 1 1 0 1 0 1 0 1 3 1 1 1 1 1 1 1 1 1 1 1 1 0 0 3 2 21 Akmal Saad Hassan (Min et al, 2018)…”

Section: Item Number In Checklistmentioning

confidence: 99%

Platelet‐rich plasma in the treatment of scars, to suggest or not to suggest? A systematic review and meta‐analysis

Ebrahimi

Alimohamadi

Janani

et al. 2022

J Tissue Eng Regen Med

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Despite the rising trend for applying platelet‐rich plasma (PRP) in the management of various types of scars, there is no convincing evidence supporting its use. This motivated us to review the randomized clinical trials that examine the effectiveness and safety of PRP, alone or in combination with other methods, for the management of atrophic or hypertrophic/keloidal scars. The Web of Science, Scopus, Google Scholar, and Cochrane Library databases were systematically searched until September 1st, 2020. Thirteen clinical trials were enrolled in the meta‐analysis, and 10 more were reviewed for their results. The random effect meta‐analysis method was used to assess the effect size of each outcome for each treatment type, and I2 was used to calculate the statistical heterogeneity between the studies. Patients treated with PRP experienced an overall response rate of 23%, comparable to the results seen with laser or micro‐needling (22% and 23%, respectively) When used alone, moderate improvement was the most frequently observed degree of response with PRP (36%) whereas, when added to laser or micro‐needling, most patients experienced marked (33%, 43%, respectively) or excellent (32% and 23%, respectively) results. Concerning the hypertrophic/keloid scars, the only study meeting the required criteria reported a better improvement and fewer adverse effects when PRP was added to the intralesional corticosteroids. Platelet‐rich plasma appears to be a safe and effective treatment for various types of atrophic scars. In addition, when added to ablative lasers or micro‐needling, it seems to considerably add to the efficacy of treatment and reduce the side effects.

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Section: Item Number In Checklistmentioning

confidence: 99%

Platelet‐rich plasma in the treatment of scars, to suggest or not to suggest? A systematic review and meta‐analysis

Ebrahimi

Alimohamadi

Janani

et al. 2022

J Tissue Eng Regen Med

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“…Nofal and colleagues 55 performed the first study highlighting the improvement of atrophic acne scars with intradermal injection of PRP. In a split-face study for bilateral atrophic scars, Hassan and colleagues 56 observed similar improvements in 30 patients treated with 3 monthly sessions of intradermal PRP alone and with combined treatment of subcision followed by PRP injection. Results demonstrated that PRP alone showed a better response, fewer side effects, and shorter downtime compared with combined subcision and PRP.…”

Section: Injectable Biochemical Cuesmentioning

confidence: 84%

The Emerging Field of Regenerative Aesthetics—Where We Are Now

et al. 2021

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BACKGROUND Regenerative aesthetics is an emerging branch of regenerative medicine with therapies aimed at recapturing youthful structure and function using the body's own systems. OBJECTIVE To introduce the field of regenerative aesthetics, and to explore themes and evidence surrounding current and emerging therapies in the field. MATERIALS AND METHODS A review of the literature was performed for each of the 3 pillars of regeneration; namely, stem cells, biochemical cues, and scaffolds. RESULTS Herein, we provide an overview of the field of regenerative aesthetics, a discussion surrounding the 3 pillars of regeneration, and an overview of the evidence supporting current and emerging therapeutic modalities that could play a pivotal role in the future of aesthetic treatments. CONCLUSION An enhanced understanding of this field can serve to further enhance our awareness about the regenerative effects of therapies we already offer, in addition to providing inspiration for future innovation.

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“…They suggested that the hematoma associated with subcision may affect the PRP growth factors. 18 A comparative study that used the combination of PRP and subcision versus subcision alone demonstrated higher improvement in the combined side (32.08%) compared to (8.33%) of subcision alone. The authors reported that the rolling acne scars showed a higher response (39.27%) followed by box-type scars (33.88%), this may be due to PRP and subcision act synergistically to improve the appearance of acne scars.…”

Section: Discussionmentioning

confidence: 96%

“…They reported that the improvement was higher on the PRP side compared to the combination side. They suggested that the hematoma associated with subcision may affect the PRP growth factors 18 . A comparative study that used the combination of PRP and subcision versus subcision alone demonstrated higher improvement in the combined side (32.08%) compared to (8.33%) of subcision alone.…”

Section: Discussionmentioning

confidence: 99%

Clinical and Histopathological evaluation of different tools for the Subcision of Atrophic Acne Scars

Ebrahim

Artima

Elardi

et al. 2021

J of Cosmetic Dermatology

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Atrophic acne scarring can affect about 75% of patients and is associated with social and psychological distress. Acne scars are classified into atrophic and hypertrophic types. 1 The atrophic type includes ice picks, boxcar, and rolling scars. Acne scarring is resulting from a consequence of abnormal wound healing which follows damage in the sebaceous follicles that may occur during the active stage of acne. 2,3 Recently, there has been a renewed interest in subcision.It can be used alone or as a part of the therapeutic plan. Subcision means using a special needle introduced under scarred tissue to cut the fibrous tissue causing a release of the scarring. [4][5][6] Multiple treatment modalities have been used for the treatment of acne scars as fractional laser and peeling but subcision has the advantage of safety use particularly in the dark skin type compared to lasers or peeling. Subcision is a mild invasive technique utilized to treat atrophic acne scars, post-surgical scars, and striae distensae. 7 It was reported that using cannula subcision in the treatment of acne scarring

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Treatment of atrophic acne scars using autologous platelet‐rich plasma vs combined subcision and autologous platelet‐rich plasma: A split‐face comparative study

Cited by 13 publications

References 20 publications

Platelet‐rich plasma in the treatment of scars, to suggest or not to suggest? A systematic review and meta‐analysis

Platelet‐rich plasma in the treatment of scars, to suggest or not to suggest? A systematic review and meta‐analysis

The Emerging Field of Regenerative Aesthetics—Where We Are Now

Clinical and Histopathological evaluation of different tools for the Subcision of Atrophic Acne Scars

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