Treatment of canine leproid granuloma syndrome: preliminary findings in seven dogs

Abstract

Based on our evolving clinical experience, a combination of rifampicin (10 to 15 mg/kg p.o., every 24 h) and clarithromycin (15 to 25 mg/kg p.o. total daily dose; given divided every 8 to 12 h) is currently recommended for treating severe or refractory cases of canine leproid granuloma syndrome. Treatment should be continued (typically for 4 to 8 weeks) until lesions are substantially reduced in size and ideally until lesions have resolved completely. A topical formulation, containing clofazimine in petroleum jelly may be used as an adjunct to systemic drug therapy. Further work is required to determine the most cost effective treatment regimen for this condition.

Ulcerated and Nonulcerated Nontuberculous Cutaneous Mycobacterial Granulomas in Cats and Dogs

“…7 More recently, we have had good results with clofazimine compounded in silver sulphasalazine, with or without dimethyl sulfoxide. 8 Historically, radiation therapy was also found to be effective, although this is, of course, no longer recommended.…”

“…once daily] and clarithromycin (7.5-12.5 mg ⁄ kg p.o. two to three times a day) is recommended for treating severe or refractory CLG, 7 in concert with topical silver sulphasalazine. Some dogs with CLG develop lesions subsequent to therapy or self-cure, often some years later; it is not known whether the new lesions represent new infections or disease recrudescence.…”

“…A marked increase in serum alanine aminotransferase activity signifies the need to change therapy to a different drug, such as clofazimine. As clofazimine can cause A combination of rifampicin (10-15 mg ⁄ kg orally once daily) and clarithromycin (7.5-12.5 mg ⁄ kg orally two to three times a day) is recommended for treating severe or refractory canine leproid granuloma, 7 in concert with topical silver sulphasalazine. Feline leprosy syndromes can be treated with combinations of two or three drugs from the table above, typically clarithromycin, pradofloxacin and rifampicin or clofazimine.…”

Granuloma leproide canino na região amazônica - relato de caso

“…A cirurgia realizada no paciente promoveu a cura, entretanto sabe-se que o uso de antibióticos pode ser uma boa alternativa (Malik et al, 2001).…”

Intra-lesional amphotericin B—Worth a try, maybe for lots of things, but we need more data!

“…The concept of intra-lesional therapy might also be usefully extended to the treatment of focal bacterial infections caused by organisms with a propensity to be drug-resistant e such as mycobacteria that cause feline leprosy 10,11 and related diseases and canine leproid granuloma syndrome 12,13 e substituting amphotericin B with a water-soluble anti-bacterial agent, such as amikacin or clofazimine (Fig 3).…”