Treatment of chronic venous disease with flavonoids: recommendations for treatment and further studies

Rabe, Eberhard; Jj, Guex; Morrison, Nick; Ramelet, Albert‐Adrien; Schuller‐Petrovič, Sanja; Scuderi, A; Staelens, I; Pannier, F.

doi:10.1177/0268355512471929

Cited by 35 publications

(33 citation statements)

References 101 publications

(106 reference statements)

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“…Phlebotonics are often used as pharmacological agents to manage CVD . Among the main classes of orally administered phlebotonics, gamma‐benzopyrones, also known as flavonoids, are of particular interest.…”

Section: Introductionmentioning

confidence: 99%

Anti‐inflammatory and antiradical effects of a 2% diosmin cream in a human skin organ culture as model

Boisnic¹,

Branchet²,

Gouhier-Kodas³

et al. 2018

J of Cosmetic Dermatology

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Section: Introductionmentioning

confidence: 99%

Anti‐inflammatory and antiradical effects of a 2% diosmin cream in a human skin organ culture as model

Boisnic¹,

Branchet²,

Gouhier-Kodas³

et al. 2018

J of Cosmetic Dermatology

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“…A rutina provoca a modificação dos parâ-metros de microcirculação com uma redução da síntese de mediadores inflamatórios e permeabilidade capilar, com diminuição de edema. Além disso, acredita-se que os flavonoides inibem a passagem de proteínas plasmá-ticas para o interstício, impedindo assim a formação de edemas [23,24]. Quanto à análise de Repetibilidade e Reprodutibilidade (R & R) [21], a variação foi considerada adequada para a cintura, parte superior da coxa e quadril inferior, significando que os dados originais foram rigorosamente with a decrease of edemas.…”

Section: Medidas Antropométricasunclassified

“…Quanto à análise de Repetibilidade e Reprodutibilidade (R & R) [21], a variação foi considerada adequada para a cintura, parte superior da coxa e quadril inferior, significando que os dados originais foram rigorosamente with a decrease of edemas. Also, previously published research indicates that flavonoids inhibit the passage of plasmatic proteins to the interstice, thus preventing the formation of edemas [23,24]. Regarding the analysis of Repeatability and Reproducibility (R&R) [21], the variation was considered adequate for the waist, upper thigh, and lower hip, meaning that the original data had been rigorously achieved.…”

Section: Medidas Antropométricasmentioning

confidence: 99%

Anticellulite efficacy of Trichilia catigua and Ptychopetalum olacoides Bentham extracts

Velasco¹,

Santos²,

Dario³

et al. 2017

BBR

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45 Biomedical and Biopharmaceutical Research J o r n a l d e I n v e s t i g a ç ã o B i o m é d i c a e B i o f a r m a c ê u t i c a Anticellulite efficacy of Trichilia catigua and Ptychopetalum olacoides Bentham extracts AbstractAmong all forms of treatment for cellulite, the most commonly used and easy to access are the cosmetic products containing active substances which are vessel-protective, anti-inflammatory, peripheral microcirculation stimulants and lipolytic agents. In this work, the clinical anticellulite efficacy of a commercial extract of Trichilia catigua (Catuaba) and Ptychopetalum olacoides Bentham (Marapuama) was evaluated. Twenty-seven woman subjects between the ages of 20 and 40 years old with moderate gynoid lipodystrophy participated in this study. The Trichilia catigua and Ptychopetalum olacoides Bentham extract was incorporated into a cosmetic emulsion, and the subjects applied this formulation once a day for 60 days. The following parameters were assessed: hypodermic layer thickness by B-mode ultrasonography, cutaneous temperature, and anthropometric measurements. The test product caused an increase in skin temperature after 60 days application without affecting the hypodermic layer thickness. In addition, a statistically significant reduction in circumference of specific body areas was observed (stomach, waist, upper thigh, upper leg, and upper hip). Thus, the results indicated that the Trichilia catigua and Ptychopetalum olacoides Bentham extract was effective in the reduction of the gynoid lipodystrophy aspect, likely by reducing edema and improving local microcirculation. Keywords: gynoid lipodystrophy, extract, ultrasonography, anthropometric test, cutaneous temperature ResumoEntre todas as formas de tratamento da celulite, as mais utilizados e de fácil acesso são os produtos cosméticos contendo substâncias ativas que são protetoras de vasos, anti-inflamatórios, estimulantes de microcirculação periférica e agentes lipolíticos. Neste trabalho, avaliou-se a eficácia clínica anticelulite de um extrato comercial de Trichilia catigua (Catuaba) e Ptychopetalum olacoides Bentham (Marapuama). Participaram deste estudo 27 mulheres voluntárias entre 20 e 40 anos com hidrolipodistrofia ginoide moderada. O extrato de Trichilia catigua e Ptychopetalum olacoides Bentham foi incorporado em uma emulsão cosmética e os voluntários aplicaram esta formulação uma vez por dia, durante 60 dias. Foram avaliados os seguintes parâmetros: espessura da camada hipodérmica por ultrassonografia em modo B, temperatura cutânea e medidas antropométricas. O produto testado propiciou aumento na temperatura da pele após 60 dias de aplicação sem afetar a espessura da camada hipodérmica. Além disso, observou-se uma redução estaticamente significativa na circunferência de áreas corporais específicas (estômago, cintura, parte superior da coxa, parte superior da perna e quadril superior). Assim, os resultados indicaram que o extrato de Trichilia catigua e Ptychopetalum olacoides Bentham foi efetivo na redução do aspecto da ...

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“…Uporabo venoaktivnih zdravil priporočajo ob simptomih in znakih KVB kot dopolnilno drugim načinom zdravljenja, vendar so potrebne dodatne kakovostne študije s primerno metodologijo, ki bodo olajšale predpisovanje teh učinko-vin (20,22,25,28).…”

Section: Zdravljenje Kvb Z Venoaktivnimi Zdraviliunclassified

Priporočila za odkrivanje in zdravljenje kronične venske bolezni

et al. 2017

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Priporočila za odkrivanje in zdravljenje kronične venske bolezniRecommendations for the diagnosis and treatment of chronic venous disease AbstractClinical manifestations of chronic superficial venous insufficiency are described, followed by recommendations for diagnostic evaluation and various treatment possibilities. Opredelitev kronične venske bolezni in popuščanjaKronična venska bolezen (KVB) zajema vse stadije bolezni od telangiektazij, varic in otekanja do kožnih sprememb z razjedo, kronično vensko popuščanje (KVP) pa napredovale faze s stalnim otekanjem in kožnimi spremembami z razjedo (1). Kronična venska bolezen je klinično opredeljena kot sklop simptomov in znakov, ki nastanejo zaradi povečanega tlaka v povrhnjih in/ali globokih venah spodnjih udov. Simptomi KVB so lahko težke noge, tope bolečine, srbenje, utrujenost nog, krči ponoči in nemirne noge. Znaki KVB so lahko metličaste vene, mrežaste vene ali krčne žile (varice), otekline in kožne spremembe, kot so temnejša obarvanost (hiperpigmentacija), lipodermatoskleroza, hipostazični dermatitis in venska razjeda (1).Povečan tlak v venah najpogosteje nastane zaradi nepravilnega delovanja venskih zaklopk, ki niso več sposobne preprečevati obratnega toka (refluksa) krvi v venah, redkeje pa zaradi zožitve ali zapore proksimalne vene. Nezadostno delovanje (insuficienca) venskih zaklopk onemogoča, da bi med hojo golenska mišična črpalka zmanjšala venski tlak v spodnjih udih na normalno raven. Okvara venskih zaklopk je najpogosteje primarna, pri kateri osnovnega vzroka ne poznamo (1). Sekundarna okvara zaklopk, ki vodi v nastanek varic, se pojavlja ob akutni venski trombozi spodnjega uda, nerekanalizirani trombozi medeničnih ven ali v sklopu potrombotičnega sindroma, prirojena (kongenital-

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Treatment of chronic venous disease with flavonoids: recommendations for treatment and further studies

Abstract: Aside from good evidence for the use of flavonoids in CVD further studies are indicated to establish long term treatment in this indication.

Cited by 35 publications

References 101 publications

Anti‐inflammatory and antiradical effects of a 2% diosmin cream in a human skin organ culture as model

Anti‐inflammatory and antiradical effects of a 2% diosmin cream in a human skin organ culture as model

Anticellulite efficacy of Trichilia catigua and Ptychopetalum olacoides Bentham extracts

Priporočila za odkrivanje in zdravljenje kronične venske bolezni

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