Treatment of Early Mammary Carcinoma A Cooperative International Study

Haagensen, C. D.; Cooley, Edith; Kennedy, Charles S.; Miller, E. B.; Handley, R. S.; Thackray, A. C.; Butcher, H. R.; Dahl-Iversen, E; Tobiassen, T; Williams, I. G.; Curwen, M. P.; Kaae, Sigvard; Johansen, H

doi:10.1097/00000658-196302000-00001

Cited by 80 publications

(9 citation statements)

References 2 publications

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“…In addition there is the obvious factor of the operable vs the inoperable state of the disease which formed the basis for referral of these patients to the surgicalor medical breast clinic, respectively. Data based on surgical staging of this disease (Columbia classification) have shown a significantly more favorable prognosis in stages A and B than in stages C and D. 8,9 Delay factors were undoubtedly involved in some of the patients who presented with advanced disease in these series. (4) Fear and lack of educational opportunities were responsible for misconceptions and misinterpretation of symptoms in the tumor service series.…”

Section: Cancer Detection Delay-lynch and Krushmentioning

confidence: 87%

Delay: A Deterrent to Cancer Detection

Lynch

Krush

1968

Archives of Environmental Health: An International Journal

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Section: Cancer Detection Delay-lynch and Krushmentioning

confidence: 87%

Delay: A Deterrent to Cancer Detection

Lynch

Krush

1968

Archives of Environmental Health: An International Journal

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“…A survival rate 80°/, has been reported after both radical mastectomy (Haagensen et al, 1969;Payne et al, 1970) and modified radical mastectomy (Madden et al, 1972 significantly influenced, not only by the existence of axillary metastases, but also by the number of nodes involved (Haagensen, 1971;Silverberg, 1975) and by their location in the axilla (Urban, 1960) where tumour growth in the apical nodes indicates an especially bad prognosis. A detailed assessment of these factors might, however, be considered inappropriate for routine use, whereas the recognition of perinodal tumour growth is easily done at a conventional histopathological examination.…”

Section: Discussionmentioning

confidence: 99%

“…However, some studies, though not randomized, have shown superior treatment results (e.g. Gray & Anglem, 1959;Haagensen et al, 1969). Furthermore, the survival rate has shown a definite tendency to improve decade by decade during this century (Mansfield, 1976 The present study was undertaken to evaluate a differentiated treatment, based primarily on tumour location and axillarynode involvement.…”

mentioning

confidence: 97%

Survival and recurrences five years after selective treatment for breast carcinoma

Adami¹,

Graffman²,

Johansson³

et al. 1978

Br J Cancer

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Summary.-110 consecutively diagnosed breast-cancer patients in all stages were included in a study to evaluate a selective surgical and radiotherapeutical treatment. The surgical treatment was total mastectomy and exploration of the axilla, with lymphnode biopsy and peroperative cytological examination. Axillary dissection was done only when this examination showed metastases. No radiotherapy was given to the axilla in patients with lateral cancers in the absence of metastases, or with limited metastasization (no periglandular growth, no growth in apical nodes). In medial and central cancers, radiotherapy was applied to the parasternal and supraclavicular nodes irrespective of axillary involvement. A staging system with a combined clinical and histopathological classification was used and formed the basis for the selective treatment.The corrected 5-year survival for the whole material was 80%, for those without axillary metastasis (Stage I) 950% and for those with axillary metastasis (Stage II) 68%. Six women were alive with known distant metastases. Of 63 patients without identified axillary metastases at the time of surgery, axillay recurrences occurred in only 3 (5 0%). It was concluded that patients without axillary metastases can be reliably selected by the peroperative examination used, and that in this group simple mastectomy results in a high disease-free survival. Early diagnosis and a possible beneficial effect of the actual therapeutic programme might both have contributed to the high overall survival.

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“…Second, controlled clinical studies should be made to confirm or disprove the reports (5–8) stating that radical breast surgery offers no advantage over simple mastectomy with radiotherapy. This opinion is vigorously opposed by some surgeons (9).…”

Section: Breast Cancermentioning

confidence: 96%

Progress in the Management of Breast Cancer and Hypoestrogenism in the Aging Female*

Rhoades

1964

J American Geriatrics Society

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Treatment of Early Mammary Carcinoma A Cooperative International Study

Cited by 80 publications

References 2 publications

Delay: A Deterrent to Cancer Detection

Delay: A Deterrent to Cancer Detection

Survival and recurrences five years after selective treatment for breast carcinoma

Progress in the Management of Breast Cancer and Hypoestrogenism in the Aging Female*

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