Treatment of geographic tongue with topical tacrolimus

Purani, Jigar M; Purani, Hiral J

doi:10.1136/bcr-2013-201268

Cited by 14 publications

(8 citation statements)

References 12 publications

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“…Clinically, GT is characterized by an erythematous, atrophic area circumscribed by a yellowish‐white line. The lesions often change their location and shape over a span of a few minutes and primarily affect the dorsum of the tongue . Kuffer demonstrated that GT lesions may also exist without delineation by a white border and proposed a clinical classification (the first described) as follows: typical, migratory lesions with a white border; atypical, nonmigratory lesions without a white border; and mixed, a combination of the two forms in a single patient .…”

Section: Introductionmentioning

confidence: 99%

“…The diagnosis of GT is based on the clinical features of the lesion, and histopathological confirmation is rarely performed, making it difficult to study its pathogenesis . Treatment is indicated only in symptomatic cases and often includes corticosteroids . Some authors suggest that GT may represent an early oral manifestation of psoriasis and have described the relationship between GT and the severity of psoriasis.…”

Section: Introductionmentioning

confidence: 99%

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Investigation of the clinical features of geographic tongue: unveiling its relationship with oral psoriasis

et al. 2017

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GT is a symptomatic lesion with a thick halo. In contrast, psoriatic patients are frequently asymptomatic and exhibit severe lesions with greater loss of papillae that are associated with severe FT. The present study is the first to demonstrate clinical differences in the GT of patients with and without psoriasis, suggesting that some GT cases may represent true oral psoriasis and some cases may represent only GT.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Investigation of the clinical features of geographic tongue: unveiling its relationship with oral psoriasis

et al. 2017

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“…Benign migratory glossitis is a pathological condition referred to in literature as geographic tongue, annulus migrans, erythema migrans, benign wandering glossitis, exfoliatio areata linguae, or transitory benign plaque of the tongue [1][2][3]. It is an asymptomatic inflammatory disorder of unknown etiology considered as a normal variant rather than an injury.…”

Section: Introductionmentioning

confidence: 99%

The Use of Phototherapy in Treatment of Geographic Tongue in Patients with Psoriasis

Pigatti¹,

Bombarda-Nunes²,

Leal³

et al. 2019

Tailored Treatments in Psoriatic Patients

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Psoriasis is an autoimmune inflammatory skin disease associated with an oral condition called benign migratory glossitis (geographical tongue). A series of light/laser with different mechanisms of action has been widely used in the last decades to treat skin psoriasis lesions. For this, the effects of phototherapy require the correct indication of the sources and parameters of light/laser in the management of different psoriatic lesions. The objective of this chapter is to update clinical knowledge on how to select light/laser sources and individual therapeutic regimens in benign migratory glossitis.

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“…Plus récemment, deux cas de LG symptomatique traité par tacrolimus local ont été décrits [2][3][4], dont l'un chez un enfant de 6 ans [4]. L'objectif de cette étude rétrospective était d'évaluer l'efficacité du tacrolimus dans le traitement des langues géo-graphiques algiques sur une série de dix patients.…”

Section: Introductionunclassified

Étude rétrospective de l’efficacité du Protopic® (tacrolimus) dans le traitement de la langue géographique algique

Haddad¹,

Boralévi

Catros³

et al. 2015

Med Buccale Chir Buccale

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Résumé -Introduction :La langue géographique (LG) est le plus souvent asymptomatique. Quand elle est douloureuse, le traitement est mal codifié. L'objectif de cette étude est d'évaluer l'efficacité du tacrolimus topique appliqué sur les LG algiques. Matériels et méthodes : Il s'agit d'une étude de cohorte descriptive, rétrospective, menée dans le service d'odontologie du CHU de Bordeaux de janvier 2012 à novembre 2013. Les patients sont traités par tacrolimus 0,1 % en application locale 2 fois par jour pendant 1 mois. Le critère de jugement principal est une évaluation de la douleur avec une échelle numérique verbale (ENV) de 0 à 10 à J0 et à 1 mois. Résultats : Trente et un patients ont consulté pour une langue géographique (LG). Sur ces 31 patients, 17 avaient des brûlures de la langue. Sur ces 17, 12 avaient une douleur imputable à la LG. Sur ces 12, 10 ont été traités par tacrolimus. Lors de la consultation initiale, l'ENV était de 5,9 +/-1,87. L'évaluation à un mois a montré une amélioration significative de l'ENV, 1,6 +/-1,5 (p < 0,001). Aucun événement indésirable grave n'est rapporté, seule une douleur oesophagienne est mentionnée chez trois patients. Conclusion : L'utilisation du tacrolimus topique semble efficace et bien tolérée dans l'indication d'une LG algique. Cependant, un essai randomisé versus placebo serait nécessaire afin de pouvoir conclure avec certitude. Abstract -Introduction:Geographic tongue is usually an asymptomatic disorder. There is no symptomatic treatment evaluated with clinical trials. Our objective was to evaluate the efficiency of tacrolimus in painful Geographic Tongue (GT). Methods: A retrospective descriptive cohort study was performed in the Department of Odontology PQR at the CHU in Bordeaux from January 2012 to November 2013. Patients with painful GT were treated with 0.1% tacrolimus (Protopic) topically twice a day for one month. The primary endpoint was the evaluation of pain with a numerical pain scale (NPS) from 0 to 10 the first day and one month later. The secondary endpoints were the improvement of the quality of life and of eating . Results: Thirty-one patients with GT consulted during the period studied. Seventeen had a burned tongue sensation, five patients presented primitive glossodynia and twelve had painful GT. Ten patients were treated with tacrolimus topically. The average value of the NPS was 5,9 (+/-1.87) at the first consultation. The GT lesions were present in all cases. Eating difficulties or a burned tongue sensation were described by patients. The evaluation one month after the prescription of Protopic showed a significant improvement of the NPS, with an average of 1,6 (+/-1.5) (t-test, p<0.001%). An improvement of the quality of life was noted for all patients. No serious adverse events were reported except esophagus pain for three patients. Conclusions: The utilization of topical tacrolimus seems to be efficient and well-tolerated in painful GT. However, randomized trials versus placebo are necessary to conclude with certitude.

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Treatment of geographic tongue with topical tacrolimus

Abstract: Geographic tongue is an inflammatory condition of the dorsal surface and lateral border of the tongue, which may be asymptomatic. This article presents a case of geographic tongue in a 6-year-old child. Successful management was achieved with topical application of 0.1% tacrolimus.

Cited by 14 publications

References 12 publications

Investigation of the clinical features of geographic tongue: unveiling its relationship with oral psoriasis

Investigation of the clinical features of geographic tongue: unveiling its relationship with oral psoriasis

The Use of Phototherapy in Treatment of Geographic Tongue in Patients with Psoriasis

Étude rétrospective de l’efficacité du Protopic® (tacrolimus) dans le traitement de la langue géographique algique

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