Treatment of hypertension with methyldopa.

Johnson, P. C.; Kitchin, A. H.; Lowther, Clifton P.; Turner, Richard

doi:10.1136/bmj.1.5480.133

Cited by 59 publications

(26 citation statements)

References 11 publications

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“…This effect may be due to a steal syndrome of shunting of blood away from the penis because of vasodilating actions. These effects have been reported at doses of between one to three g/day (Kochar, Zeller & Itskovitz 1979;Chatterji 1978;Pillay 1976;Alexander & Evans 1975;Laver 1974;Newman & Salerno 1974;Bulpitt & Dollery 1'973;Mroczek, Leibel & Finnerty 1972;Horwitz et al 1967;johnson et al 1966;Lauwers , Verstraete & Joossens 1963).…”

Section: Methyldopa (Aldomet®)mentioning

confidence: 95%

“…1968;Vejlsgaard, Christensen & Clausen 1967;Lauwers, Verstraete & joossens 1963) and is probably secondary to the blocking effect on the sympathetic stimulus. The most common sexual side effect is failure of erection, which, depending on the study, had an incidence of two percent to 80% (Pillay 1976;Alexander & Evans 1975;Prichard et al 1968;Horwitz et al 1967;Vejlsgaard, Christensen & Clausen 1967 ;johnson et al 1966 ;Dollery & Harrington 1962). This effect may be due to a steal syndrome of shunting of blood away from the penis because of vasodilating actions.…”

Section: Methyldopa (Aldomet®)mentioning

confidence: 99%

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Pharmacosexology: The Effects of Drugs on Sexual Function – A Review

Buffum

1982

Journal of Psychoactive Drugs

158

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The literature on the sexual side effects of drugs and chemicals has been reviewed. There are many substances which alter the human sociosexual response cycle either negatively, positively or both. Many of the drugs used therapeutically have been reported to have adverse effects on sexuality, and this must be taken into account when these drugs are used clinically. Many substances which are used for recreational purposes (or sometimes abused) also have profound effects on sexual response. Many of these substances are used in such a way that they can correct underlying sexual problems. Treatment of a drug abuser may well prove unsuccessful without consideration of preexistent sociosexual problems and concerns. From the dawn of recorded history, many substances have been used for the purpose of sexual enhancement. Some of these have known success and their reputations have been passed down through the millenia. The chapter has not yet been closed on aphrodisiacs, even though none have survived the rigors of scientific scrutiny. As long as humans place value on optimal sexual functioning, there will be a demand for sex-enhancing drugs. In order for the scientific and medical community to successfully meet these challenges, more effective and relevant study designs will have to be utilized in order to separate fact from fancy. The study of pharmacosexology is in its infancy, and in order for it to grow and contribute to the world body of knowledge, more researchers and clinicians must be trained in both pharmacology and sexology.

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Section: Methyldopa (Aldomet®)mentioning

confidence: 95%

Section: Methyldopa (Aldomet®)mentioning

confidence: 99%

Pharmacosexology: The Effects of Drugs on Sexual Function – A Review

Buffum

1982

Journal of Psychoactive Drugs

158

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“…Methyldopa causes depletion of brain noradrenaline, serotonin and dopamine, a t least in the * Received 17 January 1973 experimental animal (Sourkes, 1965). Drowsiness is a common side effect initially unless the starting dose is small; tiredness may be a prominent feature and the patient may become tearful and depressed (Gillespie et al 1962;Smirk, 1963;Lauwers et al 1963;Johnson et al 1966; Horwitz elt al. 1967).…”

Section: Antihypertensive Drugs and Depressionmentioning

confidence: 99%

“…1967). The incidence of depression in one series was 13% (Prichard et al 1968) but the incidence of really troublesome depression has been given as about 4% (Johnson et al 1966;Hamilton, 1968). Insomnia, nightmares and hallucinations may occur occasionally (Smirk, 1963); insomnia has been reported as a withdrawal effect (Horwitz et ,al.…”

Section: Antihypertensive Drugs and Depressionmentioning

confidence: 99%

Hypertension and Depression and Their Treatment

Simpson¹

1973

Aust N Z J Psychiatry

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“…In a comparative study of bethanidine, guanethidine and methyldopa, Prichard, Johnston, Hill & Rosenheim (1968) concluded that 'methyldopa, provided it is tolerated, produced the best all round blood pressure control of these three drugs, but 20% of our patients could not tolerate it'. One of the main problems with methyldopa therapy is the high incidence of tiredness, drowsiness and sedation associated with the drug -47% reported by Oates, Seligmann, Clark, Rousseau & Lee (1965), 75% by Prichard et al (1968), 41% by Johnson, Kitchin, Lowther & Turner (1966), and 'most cases' by Hamilton & Kopelman (1963).…”

Section: Introductionmentioning

confidence: 99%

The effects of atenolol (tenormin) and methyldopa on simple tests of central nervous function.

Bayliss¹,

Duncan²

1975

Brit J Clinical Pharma

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1Two identical studies, one comparing the effect of single doses of a new ,B-adrenoceptor blocker, atenolol (Tenormin) (50 mg and 100 mg) and placebo, and the other comparing the effect of single doses of methyldopa (250 mg and 500 mg) and placebo, in healthy volunteers, were carried out. 2 In both studies the effect of the drugs upon reaction time, critical flicker frequency, subjective drowsiness, pulse rate and blood pressure was measured. 3 Atenolol produced no effect upon reaction time, critical flicker frequency or subjective feelings, while methyldopa produced a statistically significant prolongation of reaction time and a statistically significant increase in the subjective sensation of drowsiness. 4 Atenolol produced statistically significant reductions in systolic and diastolic blood pressure and in pulse rate while methyldopa was without effect. 5 It is concluded that atenolol is unlikely to produce the side effects of sedation or drowsiness.

show abstract

Treatment of hypertension with methyldopa.

Cited by 59 publications

References 11 publications

Pharmacosexology: The Effects of Drugs on Sexual Function – A Review

Pharmacosexology: The Effects of Drugs on Sexual Function – A Review

Hypertension and Depression and Their Treatment

The effects of atenolol (tenormin) and methyldopa on simple tests of central nervous function.

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