Treatment of Irritable Bowel Syndrome With Chinese Herbal Medicine

Bensoussan, Alan; Talley, Nick; Hing, Michael; Menzies, Ross G.; Guo, Anna; Ngu, Meng C.

doi:10.1001/jama.280.18.1585

Cited by 370 publications

(246 citation statements)

References 8 publications

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“…26 At this time, there is insufficient evidence to recommend acupuncture for patients with IBS. 28 The currently approved drug classes for treatment of IBS are antispasmodics, laxatives, and antidiarrhoeal drugs.…”

Section: Discussionmentioning

confidence: 99%

“…26 Only the individualised treatment group maintained improvement at 14 weeks after completion of treatment. 26 29 Otilonium bromide (RR=0.55; 95% CI, 0.31-0.97) and hyoscine (RR=0.63; 95% CI, 0.51-0.78) were the only antispasmodics to show consistent evidence of efficacy. The most frequent adverse events were dry mouth, dizziness and blurred vision, but none of the trials reported any serious adverse events.…”

Section: Rome III Rome Ivmentioning

confidence: 99%

See 1 more Smart Citation

The current treatment landscape of irritable bowel syndrome in adults in Hong Kong: consensus statements

Chan

et al. 2017

Hong Kong Med J

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Section: Discussionmentioning

confidence: 99%

Section: Rome III Rome Ivmentioning

confidence: 99%

The current treatment landscape of irritable bowel syndrome in adults in Hong Kong: consensus statements

Chan

et al. 2017

Hong Kong Med J

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“…TCM is commonly used to treat IBS in China, although the results have been shown to be conflicting. In fact, the therapeutic effects of herbal drugs are very difficult to evaluate because of variations in botanical components, the lack of purification and quality control, and the absence of preclinical animal models, and other factors [21,22] . In this study, the rat model of PI-IBS, with associated symptoms of visceral hypersensitivity, high fecal water content, anxiety, depression, and slight colitis, was developed through stimulation with EPSD, bondage and TNBS.…”

Section: Discussionmentioning

confidence: 99%

Herbal prescription Chang'an II repairs intestinal mucosal barrier in rats with post-inflammation irritable bowel syndrome

Wang

Zheng

et al. 2015

Acta Pharmacol Sin

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Aim: The herbal prescription Chang'an II is derived from a classical TCM formula Tong-Xie-Yao-Fang for the treatment of liver-qi stagnation and spleen deficiency syndrome of irritable bowel syndrome (IBS). In this study we investigated the effects of Chang'an II on the intestinal mucosal immune barrier in a rat post-inflammation IBS (PI-IBS) model. Methods: A rat model of PI-IBS was established using a multi-stimulation paradigm including early postnatal sibling deprivation, bondage and intrarectal administration of TNBS. Four weeks after TNBS administration, the rats were treated with Chang'an II (2.85, 5.71 and 11.42 g·kg -1 ·d -1 , ig) for 14 d. Intestinal sensitivity was assessed based on the abdominal withdrawal reflex (AWR) scores and fecal water content. Open field test and two-bottle sucrose intake test were used to evaluate the behavioral changes. CD4 + and CD8 + cells were counted and IL-1β and IL-4 levels were measured in intestinal mucosa. Transmission electron microscopy was used to evaluate ultrastructural changes of the intestinal mucosal barrier. Results: PI-IBS model rats showed significantly increased AWR reactivity and fecal water content, and decreased locomotor activity and sucrose intake. Chang'an II treatment not only reduced AWR reactivity and fecal water content, but also suppressed the anxiety and depressive behaviors. Ultrastructural study revealed that the gut mucosal barrier function was severely damaged in PI-IBS model rats, whereas Chang'an II treatment relieved intestinal mucosal inflammation and repaired the gut mucosal barrier. Furthermore, PI-IBS model rats showed a significantly reduced CD4 + /CD8 + cell ratio in lamina propria and submucosa, and increased IL-1β and reduced IL-4 expression in intestinal mucosa, whereas Chang'an II treatment reversed PI-IBS-induced changes in CD4 + /CD8 + cell ratio and expression of IL-1β and IL-4. Conclusion: Chang'an II treatment protects the intestinal mucosa against PI-IBS through anti-inflammatory, immunomodulatory and anti-anxiety effects.

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“…O primeiro é a discussão de Kaptchuck 18 (2000) sobre testes clínicos controlados. 19 No capítulo intitulado "O encontro científico com as medicinas do leste asiático: eficácia e eventos adversos", o autor apresenta análise sobre estudo realizado na Universidade de Sydney, Austrália, no final dos anos 1990 (Bensoussan et al, 1998). Já na apresentação, qualifica o estudo de sofisticado e "capaz de respeitar totalmente o diagnóstico e a terapêutica da medicina chinesa" (Kaptchuck, 2000, p.369).…”

Section: O Cenário Atual Da Pesquisa Em Medicina Chinesaunclassified

“…Ora, ao considerarmos um grupo de tratamento cujo terapeuta não pode interferir na formulação, estamos limitando suas possibilidades terapêuticas em nome da padronização -substâncias e medidas iguais para todos. Por sua vez, o outro grupo ativo nos mostra a possibilidade de adequar substâncias e medidas de acordo com a singularidade dos sujeitos, sendo que o resultado final indica que "apenas os pacientes que receberam fórmulas individualizadas mantiveram as melhoras obtidas" (Kaptchuck, 2000, p.369;Bensoussan et al, 1998Bensoussan et al, , p.1588.…”

Section: Crítica àS Diretrizes De Pesquisaunclassified

Análise crítica das diretrizes de pesquisa em medicina chinesa

Souza

Luz

2011

Hist. cienc. saude-Manguinhos

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A aculturação da medicina chinesa nos países ocidentais a partir da década de 1970 tem criado questionamentos sobre sua eficácia, validade e possibilidades de atuação. A pesquisa em medicina chinesa é um desafio metodológico que tem sido fundamentado em ensaios clínicos estatísticos. Neste artigo, elabora-se uma análise crítica dos problemas resultantes da aplicação de metodologias científicas comuns à biomedicina na pesquisa em medicina chinesa, propondo reorientações em suas diretrizes. A análise de textos é a metodologia principal e aborda-se o objeto a partir de referenciais teóricos das ciências sociais aplicadas à saúde.

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Treatment of Irritable Bowel Syndrome With Chinese Herbal Medicine

Cited by 370 publications

References 8 publications

The current treatment landscape of irritable bowel syndrome in adults in Hong Kong: consensus statements

The current treatment landscape of irritable bowel syndrome in adults in Hong Kong: consensus statements

Herbal prescription Chang'an II repairs intestinal mucosal barrier in rats with post-inflammation irritable bowel syndrome

Análise crítica das diretrizes de pesquisa em medicina chinesa

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