Treatment of Metastatic Chemodectoma

Massey, Vickie; Wallner, Kent

doi:10.1002/1097-0142(19920201)69:3<790::aid-cncr2820690329>3.0.co;2-u

Cited by 52 publications

(30 citation statements)

References 4 publications

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“…The results of 'standard' chemotherapy are modest (Massey & Wallner 1992, Patel et al 1995, Pipas & Krywicki 2000, Moskovic et al 2010, in line with theoretical arguments against the efficacy of classic chemotherapy for slow-growing tumours. Somatostatin analogue (SSA) treatment for receptor-positive tumours has also not shown a major benefit (Duet et al 2005).…”

Section: Treatment Of Malignant Hnpglsmentioning

confidence: 70%

The management of head-and-neck paragangliomas

Căpățînă

Ntali

Karavitaki

et al. 2013

Endocrine-Related Cancer

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Paragangliomas (PGLs) are tumours originating from neural crest-derived cells situated in the region of the autonomic nervous system ganglia. Head-and-neck PGLs (HNPGLs) originate from the sympathetic and parasympathetic paraganglia, most frequently from the carotid bodies and jugular, tympanic and vagal paraganglia, and are usually non-catecholamine secreting. Familial PGLs are considered to be rare, but recently genetic syndromes including multiple PGLs and/or phaeochromocytomas have been more thoroughly characterised. Nowadays, genetic screening for the genes frequently implicated in both familial and sporadic cases is routinely being recommended. HNPGLs are mostly benign, generally slow-growing tumours. Continuous growth leads to the involvement of adjacent neurovascular structures with increased morbidity rates and treatment-related complications. Optimal management mostly depends on tumour location, local involvement of neurovascular structures, estimated malignancy risk, patient age and general health. Surgery is the only treatment option offering the chance of cure but with significant morbidity rates, so a more conservative approach is usually considered, especially in the more difficult cases. Radiotherapy (fractionated or stereotactic radiosurgery) leads to tumour growth arrest and symptomatic improvement in the short term in many cases, but the longterm consequences are unclear. Early detection is essential in order to increase the chance of cure with a lower morbidity rate. The constant improvement in diagnostic imaging, surgical and radiation techniques has led to a safer management of these tumours, but there are still many therapeutic challenges, and no treatment algorithm has been agreed upon until now. The management of HNPGLs requires a multidisciplinary effort addressing the genetic, surgical, radiotherapeutic, oncological, neurological and endocrinological implications. Further progress in the understanding of their pathogenesis will lead to more effective screening and earlier diagnosis, both critical to successful treatment.

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Section: Treatment Of Malignant Hnpglsmentioning

confidence: 70%

The management of head-and-neck paragangliomas

Căpățînă

Ntali

Karavitaki

et al. 2013

Endocrine-Related Cancer

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“…7) Chemotherapy for paraganglioma with metastases has been reported to be basically unsuccessful. 10) In our case, combination chemotherapy of paclitaxel and gemcitabine showed no obvious improvement for the pulmonary metastases. Therefore, radical resection of the primary jugular paraganglioma might be the most effective method for control of the pulmonary metastases.…”

Section: Discussionmentioning

confidence: 52%

Craniocervical Paraganglioma With Numerous Pulmonary Metastases -Case Report-

Kamoshima

Sawamura

Hokari

et al. 2008

Neurol. Med. Chir.(Tokyo)

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A 28-year-old man presented with a rare craniocervical paraganglioma with multiple pulmonary metastases manifesting as hearing disturbance, hoarseness, and dysphagia in February 2003. Magnetic resonance imaging depicted a large jugular foramen tumor extending to the deep cervical region. Chest computed tomography revealed numerous small pulmonary nodules. The jugular tumor was totally resected immediately after preoperative embolization. Histological examination revealed paraganglioma. Localized irradiation (54 Gy) and two courses of combination chemotherapy consisting of paclitaxel (80 mg/m 2 ) and gemcitabine (1000 mg/m 2 ) were given. The patient remained well during follow up for 48 months and the number of pulmonary metastases did not increase. Local control of primary craniocervical paraganglioma by palliative surgical resection may be effective for control of metastatic lesions.

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“…Primer tümörün yavaş büyüme özelliğinden dolayı primer tümöre bağlı ölüm nadirdir (6). Tümörün fonksiyonel özelliğinin belirlenmesi için operasyon öncesi 24 saatlik idrarda VMA, 5-HİAA, HVA, metanefrin ve normetanefrin değerleri araştırılmalıdır.…”

Section: Discussionunclassified

Retroperitoneal Paraganglioma: Olgu Sunumu

Çelik¹,

Demir²,

Tuna³

et al. 2014

uob

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Retroperitoneal paragangliomalar nadir görülen nöral krest orjinli nöroendokrin tümörlerdir. Çoğunlukla benign tümörlerdir, fakat malign olanları agresif seyredebilir ve metastaza yol açabilir. Retroperitoneal paragangliomaların temel tedavi seçeneği kitlenin komplet rezeksiyonudur. Cerrahi sonrası malignite potansiyeli açısından takip önemlidir. Bu yazıda 18 yaşında, sağ böbrek anteriorunda 8,5 cm kitle saptanan ve cerrahi olarak eksize ettiğimiz kadın hastayı sunmayı amaçladık. (Üroonkoloji Bülteni 2014;13:184-186) Anah tar Ke li me ler: Feokromasitoma, nonfonksiyone paraganglioma, nöroendokrin tümör, retroperitoneal paraganglioma Retroperitoneal paragangliomas are rare neuroendocrine tumors of neural crest origin. They are mostly benign, however; malignant tumors may present aggressive behavior and may lead to metastasis. Complete surgical resection of the mass is the only potential curative treatment modality for retroperitoneal paragangliomas. Postsurgical follow-up is important for malignant potential. Here we report a case of a 18 year-old female with an 8.5 cm mass located anterior of the right kidney, treated by complete surgical excision. (Bulletin of Urooncology 2014;13:184-186)

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Treatment of Metastatic Chemodectoma

Cited by 52 publications

References 4 publications

The management of head-and-neck paragangliomas

The management of head-and-neck paragangliomas

Craniocervical Paraganglioma With Numerous Pulmonary Metastases -Case Report-

Retroperitoneal Paraganglioma: Olgu Sunumu

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