Treatment of metastatic osteosarcoma at diagnosis: a Pediatric Oncology Group Study.

Harris, Michael B.; Gieser, Peter; Goorin, Allen M.; Ayala, Alberto G.; Shochat, Stephen J.; Ferguson, William S.; Holbrook, Tate; Link, Michael P.

doi:10.1200/jco.1998.16.11.3641

Cited by 169 publications

(129 citation statements)

References 10 publications

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“…Moreover, of the 20% of patients that present with primary metastatic osteosarcoma, the prognosis, even with aggressive treatment, remains poor, with a 5-year survival of B30%. 5,6 Hence, it is clear that novel therapies are indeed needed to improve the outcome of these patients.…”

Section: Introductionmentioning

confidence: 99%

Pigment epithelium-derived factor overexpression inhibits orthotopic osteosarcoma growth, angiogenesis and metastasis

Dass

Contreras

et al. 2007

Cancer Gene Ther

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Despite significant improvements, the current management of primary osteosarcoma is still limited by the development of metastatic disease, which occurs in approximately 30% of patients despite aggressive multiagent chemotherapy and tumor-ablative surgery. Therefore, there is a need for the development of novel agents to improve the outcome of these patients. Pigment epithelium-derived factor (PEDF) has been shown to be one of the most potent inhibitors of angiogenesis, and more recently has demonstrated a functional role in tumor growth, invasion and metastasis. In this study we report, for the first time, the multitargeted role of PEDF in the inhibition of growth, angiogenesis and metastasis of two orthotopic models of osteosarcoma (rat UMR 106-01 and human SaOS-2). Through stable plasmid-mediated gene transfer of full-length human PEDF, we show that PEDF overexpression significantly reduced tumor cell proliferation (Po0.05) and Matrigel invasion (UMR PEDF , Po0.001; SaOS PEDF , Po0.05) and increased adhesion to collagen type-1 (Po0.01), in vitro. In vivo, PEDF overexpression dramatically suppressed orthotopic osteosarcoma growth (Po0.05) and the development of spontaneous pulmonary metastases (UMR PEDF , Po0.05; SaOS PEDF , Po0.001). Furthermore, PEDF-overexpressing tumors exhibited reduced intratumoral angiogenesis, evidenced by a significant decrease in microvessel density (Po0.05). Therefore, together these results suggest that PEDF may be a new and promising approach for the treatment of osteosarcoma.

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Section: Introductionmentioning

confidence: 99%

Pigment epithelium-derived factor overexpression inhibits orthotopic osteosarcoma growth, angiogenesis and metastasis

Dass

Contreras

et al. 2007

Cancer Gene Ther

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“…4 Patients with metastatic disease at diagnosis have a poor prognosis with a 5-year event-free survival of 30%. 5,6 Among this group, the prognosis of patients with multifocal osteosarcoma [7][8][9] or with axial metastases 6 is the most severe.…”

Section: Introductionmentioning

confidence: 99%

Poor prognosis osteosarcoma: new therapeutic approach

Biasin

Mereuta

Muraro

et al. 2008

Bone Marrow Transplant

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“…Various novel improvements have been established for the treatment of patients with osteosarcoma; however the diagnosis of metastasis has not been well studied (6,7). In order to detect osteosarcoma metastasis at an early stage to facilitate the effective treatment and management of the disease, the identification of genes underlying osteosarcoma metastasis is essential.…”

Section: Discussionmentioning

confidence: 99%

“…Osteosarcoma progression results in cell migration from the primary tumor, invading the lung tissue and establishing metastatic nodules in the lungs (5). Various novel improvements have been established for the treatment of patients with osteosarcoma, but metastatic disease diagnosis has not been well-studied (6,7). This is due to the poor understanding of the molecular basis of osteosarcoma metastasis genes.…”

Section: Introductionmentioning

confidence: 98%

Identification and functional study of osteosarcoma metastasis marker genes

Shi

Tang

et al. 2015

Oncology Letters

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Abstract. To date, osteosarcoma metastasis genes, which are key for accurate initial diagnosis of the disease, have not been well identified. In the present study, osteosarcoma samples with and without metastasis were collected from 31 patients. Specific complementary DNA subtraction techniques were used to identify the osteosarcoma metastasis transcripts, which are responsible for the metastasis of osteosarcoma. The specific differentially expressed transcripts were identified by Basic Local Alignment Search Tool analysis and the results were validated by immunoblotting. Specifically, ezrin and β4 integrin were employed as markers to detect osteosarcoma metastasis in the initial stages. The results of the present study indicated that the two transcripts, ezrin and β4 integrin, were highly expressed in patients with osteosarcoma metastasis, and concluded that these were osteosarcoma metastasis genes. These results indicate that β4 integrin and/or ezrin may be used as a novel marker for the detection of osteosarcoma metastasis in the initial stages.

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Treatment of metastatic osteosarcoma at diagnosis: a Pediatric Oncology Group Study.

Abstract: This ifosfamide-containing regimen is tolerable and effective in the treatment of patients with osteosarcoma (OS) who present with lung metastases. However, better regimens are required for this group of patients.

Cited by 169 publications

References 10 publications

Pigment epithelium-derived factor overexpression inhibits orthotopic osteosarcoma growth, angiogenesis and metastasis

Pigment epithelium-derived factor overexpression inhibits orthotopic osteosarcoma growth, angiogenesis and metastasis

Poor prognosis osteosarcoma: new therapeutic approach

Identification and functional study of osteosarcoma metastasis marker genes

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