Treatment of Retinal Breaks with Autologous Serum in an Experimental Model

Christmas, Nancy J.; Skolik, S; Howard, Martha A.; Saito, Yoshihiro; Barnstable, Colin J.; Liggett, Peter E.

doi:10.1016/s0161-6420(95)31046-9

Cited by 31 publications

(6 citation statements)

References 31 publications

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“…Gaudric and colleagues8 suggested in a preliminary report that an autologous platelet preparation is beneficial in treating macular holes and others have reported the successful use of platelets in a small number of cases 1516 and autologous serum has been shown to promote closure of experimental retinal tears in the rabbit retina 17…”

Section: Discussionmentioning

confidence: 99%

Surgical management of macular holes: results using gas tamponade alone, or in combination with autologous platelet concentrate, or transforming growth factor beta 2

Minihan

Goggin

Cleary

1997

British Journal of Ophthalmology

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Background-Vitrectomy and gas tamponade has become a recognised technique for the treatment of macular holes. In an attempt to improve the anatomic and visual success of the procedure, various adjunctive therapies-cytokines, serum, and platelets-have been employed. A consecutive series of 85 eyes which underwent macular hole surgery using gas tamponade alone, or gas tamponade with either the cytokine transforming growth factor 2 (TGF-2) or autologous platelet concentrate is reported. Methods-Twenty eyes had vitrectomy and 20% SF 6 gas tamponade; 15 had vitrectomy, 20% SF 6 gas, and TGF-2; 50 had vitrectomy, 16% C 3 F 8 gas tamponade, and 0.1 ml of autologous platelet concentrate prepared during the procedure. Results-Anatomic success occurred in 86% of eyes, with 96% of the platelet treated group achieving closure of the macular hole. Visual acuity improved by two lines or more in 65% of the SF 6 only group, 33% of those treated with TGF-2, and in 74% of the platelet treated group. In the platelet treated group 40% achieved 6/12 or better and 62% achieved 6/18 or better. The best visual results were obtained in stage 2 holes. Conclusion-Vitrectomy for macular holes is often of benefit and patients may recover good visual acuity, especially early in the disease process. The procedure has a number of serious complications, and the postoperative posturing requirement is diYcult. Patients need to be informed of such concerns before surgery.

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Section: Discussionmentioning

confidence: 99%

Surgical management of macular holes: results using gas tamponade alone, or in combination with autologous platelet concentrate, or transforming growth factor beta 2

Minihan

Goggin

Cleary

1997

British Journal of Ophthalmology

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“…Glial cells contribute to the repair of macular holes [276,277]. A combination of vitrectomy and administration of autologous serum or platelet suspension (which induces proliferation and migration of retinal glial cells [61]) encourage the closure of retinal breaks, and the holes are plugged by a scar composed of retinal glial cells, pigment epithelial cells, and fibroblasts [278].…”

Section: Summary and Perspectivesmentioning

confidence: 99%

Involvement of Müller glial cells in epiretinal membrane formation

Bringmann

Wiedemann

2009

Graefes Arch Clin Exp Ophthalmol

174

114

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“…Smiddy et al initially examined the effects of porcine TGFβ 1 on rabbit retinal wound healing and demonstrated a greater fibrotic response than in controls [28]. Christmas et al subsequently studied the effects of AS on chorioretinal adhesion following retinectomy [7]. They concluded that fibrocellular proliferation and migration was more evident in serum-treated eyes than in control eyes.…”

Section: Discussionmentioning

confidence: 99%