Treatment of Retinopathy of Prematurity with topical ketorolac tromethamine: a preliminary study

Avila-Vázquez, Medardo; Maffrand, Roque; Sosa, Mirta; Franco, María José Puyalto; Alvarez, Beatriz Vaca de; Cafferata, María Luisa; Bergel, Eduardo

doi:10.1186/1471-2431-4-15

Cited by 24 publications

(18 citation statements)

References 29 publications

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“…Upon topical application, ketorolac diminishes prostaglandin E 2 concentration in aqueous humor [ 74 ]. A recent preliminary report suggests that ketorolac in the form of an ophthalmic solution can reduce the risk of developing severe ROP in very preterm newborns, without producing significant adverse side effects [ 75 ]. Interestingly, the authors showed that the incidence of severe ROP was significantly lower in very preterm newborns treated with ketorolac, when compared to the controls not receiving such treatment.…”

Section: Retinopathy Of Prematurity (Rop)mentioning

confidence: 99%

Ischemic Retinopathies: Oxidative Stress and Inflammation

Rivera

Dabouz

Noueihed

et al. 2017

Oxidative Medicine and Cellular Longevity

117

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Ischemic retinopathies (IRs), such as retinopathy of prematurity (ROP), diabetic retinopathy (DR), and (in many cases) age-related macular degeneration (AMD), are ocular disorders characterized by an initial phase of microvascular changes that results in ischemia, followed by a second phase of abnormal neovascularization that may culminate into retinal detachment and blindness. IRs are complex retinal conditions in which several factors play a key role during the development of the different pathological stages of the disease. Increasing evidence reveals that oxidative stress and inflammatory processes are important contributors to the pathogenesis of IRs. Despite the beneficial effects of the photocoagulation and anti-VEGF therapy during neovascularization phase, the need to identify novel targets to prevent initial phases of these ocular pathologies is still needed. In this review, we provide an update on the involvement of oxidative stress and inflammation in the progression of IRs and address some therapeutic interventions by using antioxidants and anti-inflammatory agents.

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Section: Retinopathy Of Prematurity (Rop)mentioning

confidence: 99%

Ischemic Retinopathies: Oxidative Stress and Inflammation

Rivera

Dabouz

Noueihed

et al. 2017

Oxidative Medicine and Cellular Longevity

117

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“…Oxygen therapy was administered for a substantially longer duration in the control group. This suggests that ketorolac in the form of an ophthalmic solution can reduce the danger of developing severe ROP in very preterm newborns, without producing substantial adverse effects …”

Section: Ketorolac In Childrenmentioning

confidence: 99%

Ketorolac Tromethamine – Routes and Clinical Implications

et al. 2014

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Opioids have long been used for analgesic purposes for a wide range of procedures. However, the binding of these drugs to opiate receptors has created various challenges to the clinician due to unfavorable side effect profiles and the potential for tolerance and abuse. In 1989, ketorolac became an approved nonsteroidal inflammatory drug (NSAID) for injectable use as an analgesic. Over the last 20 years, numerous studies have been conducted involving ketorolac. These studies have provided additional information about various routes of administration and their effect on the efficacy and the side effect profile of ketorolac. Moreover, ketorolac has been compared with several widely used analgesics. This review evaluates both the potential benefits and potential drawbacks of ketorolac generally, and specifically discusses routes of administration, including their advantages and disadvantages when compared to several traditional analgesics in both inpatient and outpatient settings.

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“…Caffeine citrate, which is used worldwide and is standard of care for AOP [143, 144] has been shown to have antioxidant properties [145], to significantly reduce the incidence of severe ROP [146], and to normalize aberrant retinal proteomic profiles in OIR [147]. Non-steroidal anti-inflammatory drugs (NSAIDs) have also been shown to reduce the incidence of ROP [148]. Caffeine and NSAID synergism was protective against severe OIR using our IH/IHR model [139].…”

Section: Discussionmentioning

confidence: 99%

Neonatal Intermittent Hypoxia, Reactive Oxygen Species, and Oxygen-Induced Retinopathy

Beharry

Cai

Valencia

et al. 2017

ROS

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Most of the major morbidities in the preterm newborn are caused by or are associated with oxygen–induced injuries and are aptly called “oxygen radical diseases in neonatology or ORDIN”. These include bronchopulmonary dysplasia, retinopathy of prematurity, periventricular leukomalacia, intraventricular hemorrhage, necrotizing enterocolitis and others. Relative hyperoxia immediately after birth, immature antioxidant systems, biomolecular events favoring oxidative stress such as iron availability and the role of hydrogen peroxide as a key molecular mediator of these events are reviewed. Potential therapeutic strategies such as caffeine, antioxidants, non-steroidal anti-inflammatory drugs, and others targeted to these critical sites may help prevent oxidative radical diseases in the newborn resulting in improved neonatal outcomes.

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Treatment of Retinopathy of Prematurity with topical ketorolac tromethamine: a preliminary study

Cited by 24 publications

References 29 publications

Ischemic Retinopathies: Oxidative Stress and Inflammation

Ischemic Retinopathies: Oxidative Stress and Inflammation

Ketorolac Tromethamine – Routes and Clinical Implications

Neonatal Intermittent Hypoxia, Reactive Oxygen Species, and Oxygen-Induced Retinopathy

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