Treatments for iron-deficiency anaemia in pregnancy

Revéiz, Ludovic; Gyte, Gillian ML; Cuervo, Luis Gabriel

doi:10.1002/14651858.cd003094.pub2

Cited by 123 publications

(153 citation statements)

References 57 publications

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“…1 Placenta previa exists when the placenta is inserted wholly or in part into the lower segment of the uterus. Reported incidence of placenta previa averages 0.3% or 1 case in 300 to 400 deliveries.…”

Section: Introductionmentioning

confidence: 99%

Current placenta previa management and outcome in a rural tertiary care centre

Sood

Sharma

Nagpal

et al. 2017

Int J Reprod Contracept Obstet Gynecol

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Background: The reported incidence for placenta previa averages 0.3% or 1 case in 300 to 400 deliveries. Multiparity, advanced maternal age, cigarette smoking, previous caesarean delivery, history of abortions or uterine surgical procedures are some of the risk factors contributing to the development of placenta previa. Massive obstetrical haemorrhage in placenta previa is associated with severe maternal morbidity and mortality. A significant number of mothers can be saved if right approach of management is followed in placenta previa.Methods: The present case study is a retrospective analysis carried out in a tertiary care centre to study the risk factors and maternal and perinatal outcome in cases of placenta previa. The study included antenatal patients diagnosed as placenta previa on sonography at or >26 weeks of pregnancy. Data was compiled and statistically analysed.Results: Incidence of Placenta Previa in our study was 0.54%. 73.2% patients had history of previous cesarean sections. 53.6% patients were referred from outside. 98.2% patients delivered by caesarean section. Obstetric hysterectomy was required in 3.5% of total cases. 10.7% cases required the ICU admission after delivery. There was no maternal mortality in the study group. The mean gestational age at delivery was 35±2.4weeks. The mean APGAR at 5 min was 9±2.2.Conclusions: Increasing rates of caesarean sections in present era indicate that incidence of Placenta Previa is expected to rise. Good antenatal care, availability of emergency obstetric services, infrastructure, blood bank facility, HDU and ICU care and NICU services can improve maternal and neonatal outcome.

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Section: Introductionmentioning

confidence: 99%

Current placenta previa management and outcome in a rural tertiary care centre

Sood

Sharma

Nagpal

et al. 2017

Int J Reprod Contracept Obstet Gynecol

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“…2,9,11,12 Moreover, current guidelines recommend a daily iron supplementation of at least 60 mg of elemental iron after the 16 th -20 th week of gestation or sooner if there are any risk factors. 1,13,14 The iron status can be determined by a serum ferritin (SF) assay that has the highest sensitivity and specificity to diagnose iron deficiency. 7,15 Serum ferritin identifies iron deficiency earlier than other biomarkers such as Hb and transferring saturation (TS) but can be increased in the presence of inflammation or infection.…”

Section: Introductionmentioning

confidence: 99%

“…If a critical value of Hg is achieved, blood transfusion has to be considered. 12,14,15 With this study we seek to assess the occurrence of anemia and iron deficiency in a Portuguese population, as well as the risk factors for iron deficiency during the first half of pregnancy.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and Risk Factors for Iron Deficiency Anemia and Iron Depletion During Pregnancy: A Prospective Study

et al. 2016

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RESUMOIntrodução: A anemia e a carência de ferro são problemas de saúde globais e são mais frequentes em grávidas, mulheres em idade reprodutiva e crianças. O objetivo deste trabalho consistiu na avaliação da prevalência de anemia ferropénica e dos fatores de risco associados à ferropénia, na primeira metade da gravidez, numa amostra da população portuguesa. ABSTRACT Introduction: Anemia and iron deficiency during pregnancy are a worldwide concern and are more frequent among women of reproductive age, pregnant women, and young children. The aim of this study was to assess the prevalence of iron deficiency anemia and the risk factors for iron depletion during the first half of pregnancy, in a Portuguese population. Material and Methods:A prospective study was conducted at a tertiary hospital and included pregnant women, until the 20th week of gestation. Data was collected regarding demographic and pregnancy features and hemoglobin and serum ferritin concentrations were determined. A multivariate logistic regression was performed to identify potential risk factors for iron deficiency. Results: Two hundred and one women were included, from which five (2.49%) presented anemia. Additionally, 77 (38.3%) exhibited iron deficiency and 22 (10.9%) revealed severe iron depletion. Maternal age was the only risk factor identified. The odds ratio (OR) was equal to 12.99 (95% CI 2.41 -70.0) for women under twenty years of age and 2.09 (95% CI 1.05 -4.14) for women older than thirty years of age. Discussion and Conclusion:The prevalence of maternal anemia in the first half of pregnancy was lower than in other studies. However, more than one-third of the women exhibited iron deficiency. With the exception of maternal age, no other risk factors were identified.

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“…The observation study from Zurich reported rashes and flush as the common side effects from 0.36 % of infusions [13]. Other studies have reported unpleasant metallic taste and flushing during transfusion, vomiting, cough, pruritus and muscle pain as side effects [12,[14][15][16][17][18] There were two reports of non-fatal anaphylactic reactions in the current study. None of the above studies reported serious reactions.…”

Section: Discussionmentioning

confidence: 55%

“…Studies have shown that intravenous iron sucrose (IS) is effective in raising haemoglobin faster and in replenishing the iron stores [12][13][14][15][16] However, these studies are very small and safety data are not very well established among pregnant women. In India, this preparation has been in use in private and public health facilities in some states for the past few years.…”

Section: Introductionmentioning

confidence: 99%

An Observational Study on the Use of IV Iron Sucrose Among Anaemic Pregnant Women in Government Healthcare Facilities from Two States of India

Devasenapathy

Singh

Moodbidri

et al. 2014

J Obstet Gynecol India

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Background/Purpose of the Study In India oral iron tablets for anaemia have been distributed through the health system since many years, but there has been no significant change in the burden of anaemia. The objective of the present study was to capture the existing practices on the use of intravenous iron sucrose (an alternative treatment for anaemia) in the public health system in two states of India (Tamil Nadu and Uttar Pradesh). Methods An observational study in the form of a registry was maintained for 3 months at purposively chosen public health facilities in the above-mentioned states of India. 123Anaemic pregnant women (n = 764) who were given intravenous iron sucrose during the antenatal or post-partum period were included in the registry. Information was collected on severity of anaemia at which intravenous iron sucrose therapy was initiated, the dose and schedule given and any adverse events noted during and immediate postinfusion period. Results 99 % of the infusions were given as slow infusion over a mean duration of 30 min, diluted with 0.9 % sodium chloride. The mean haemoglobin level at the time of start of intravenous therapy was 8.3 gm/dl. In Uttar Pradesh, 46 % of women received only one dose of iron sucrose in contrast with 15 % in Tamil Nadu. Conclusions Although intravenous iron sucrose is commonly used in pregnant anaemic women, standard protocols and guidelines for its usage are lacking. These need to be formulated before scaling it up across public health facilities in India.

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Treatments for iron-deficiency anaemia in pregnancy

Cited by 123 publications

References 57 publications

Current placenta previa management and outcome in a rural tertiary care centre

Current placenta previa management and outcome in a rural tertiary care centre

Prevalence and Risk Factors for Iron Deficiency Anemia and Iron Depletion During Pregnancy: A Prospective Study

An Observational Study on the Use of IV Iron Sucrose Among Anaemic Pregnant Women in Government Healthcare Facilities from Two States of India

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