Tremella fuciformis polysaccharides ameliorated ulcerative colitis via inhibiting inflammation and enhancing intestinal epithelial barrier function

Xiao, Hong; Li, Hailun; Wen, Yifan; Dongxu, Jiang; Zhu, Shumin; He, Xiaoyun; Xiong, Qingping; Gao, Jie; Hou, Shaozhen; Huang, Song; He, Lian; Liang, Jian

doi:10.1016/j.ijbiomac.2021.03.083

Cited by 67 publications

(33 citation statements)

References 35 publications

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“…Bark has been used in China for thousands of years due to its unique flavour and positive role in disease prevention and treatment ( Wu et al, 2019 ; Yuan et al, 2022 ). As one of its active components, Tremella polysaccharide (TP) has many pharmacological effects, such as lowering blood glucose and lipid ( Kim et al, 2009 ; Bach et al, 2015 ; Chiu et al, 2022 ; Zhang et al, 2023 )and immunomodulation ( Shi et al, 2014 ; Xiao et al, 2021 ; Khan et al, 2022 ; Xie et al, 2022 ). In addition, the anti-radiation ( Xu et al, 2012 ), anti-ageing ( Tao et al, 2017 ) and antioxidant ( Chen, 2010 ) effects of TP have also been reported.…”

Section: Introductionmentioning

confidence: 99%

Tremella fuciformis polysaccharide reduces obesity in high-fat diet-fed mice by modulation of gut microbiota

Chen

Huang

et al. 2022

Front. Microbiol.

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Obesity is a metabolic disease associated with gut microbiota and low-grade chronic inflammation. Tremella fuciformis is a medicinal and edible fungus; polysaccharide (TP) is the main active component, which has a variety of biological activities, such as hypoglycemic and hypolipidemic. However, the anti-obesity effects and potential mechanisms of TP have never been reported. This study was conducted to elucidate the inhibitory effect of TP on high-fat diet (HFD)-induced obesity in mice. Mice were split into five groups: normal chow diet (NCD) group, NCD_TP_H group, HFD group, HFD_TP_L group and HFD_TP_H group. Our study showed that TP inhibited high-fat diet-induced weight gain and fat accumulation in mice and reduced blood glucose, hyperlipidemia and inflammation. TP also improved gut microbiota disorders by reducing the Firmicutes/Bacteroidetes ratio and modulating the relative abundance of specific gut microbiota. We also found that the anti-obesity and gut microbiota-modulating effects of TP could be transferred to HFD-fed mice via faecal microbiota transplantation (FMT), confirming that the gut microbiota was one of the targets of TP for obesity inhibition. Further studies showed that TP increased the production of short-chain fatty acids and the secretion of intestinal hormones. Our studies showed that TP inhibited obesity by modulating inflammation and the microbe-gut-brain axis, providing a rationale for developing TP to treat obesity and its complications.

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Section: Introductionmentioning

confidence: 99%

Tremella fuciformis polysaccharide reduces obesity in high-fat diet-fed mice by modulation of gut microbiota

Chen

Huang

et al. 2022

Front. Microbiol.

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“…Therefore, safe and effective natural plant-derived medicines for the treatment of UC need to be developed [ 5 ]. A growing body of research has reported that the polysaccharides present in many traditional Chinese medicines, such as Tremella fuciformis polysaccharides [ 23 ] and Atractylodes macrocephala polysaccharides [ 19 ], play a crucial role in the treatment of UC. In our study, 37.6% polysaccharides and 3.5% protein were detected in CSWE.…”

Section: Discussionmentioning

confidence: 99%

Capparis spinosa Alleviates DSS-Induced Ulcerative Colitis via Regulation of the Gut Microbiota and Oxidative Stress

Zhu

Yang

Gao

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Ulcerative colitis (UC) is a chronic inflammatory disease. Here, the potential effects of Capparis spinosa water extract (CSWE) on colonic histopathology, inflammation, and gut microbiota composition in dextran sulfate sodium (DSS) induced UC mice were evaluated. Our results showed that CSWE treatment improved the colonic histopathology of UC mice, increased the levels of tight junction protein gene ZO-1 and Occludin in intestinal epithelial cells, and inhibited the expression of proinflammatory cytokines (IL-1β, IL-6, and TNF-α). Furthermore, CSWE administration alleviated oxidative stress in the colon of UC mice. The effects of CSWE on the compositions and metabolomic profiles of the gut microbiota in UC mice were investigated. It was found that CSWE could enhance the diversity of gut microbes and the abundance of probiotics and metabonomics had the strongest association with Firmicutes. Our results indicated that CSWE might be an ideal candidate as a potential therapeutic natural product for the treatment of UC.

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“…Commonly used methods for deproteinizing crude polysaccharides include the Sevag, protease, trichloroacetic acid, and calcium chloride method, and so on (Fan et al, 2022; C. Huang et al, 2021; W. Yang et al, 2022). The protein removal in WJP is generally removed by the Sevag method and then treated with papain (Xiao et al, 2021), which can increase the yield of WJP, avoid the destruction of its glycosidic bonds and reduce the use of organic solvents (L. Wang et al, 2021). However, when using the enzymatic method to remove protein, consider the level of protein in the sample.…”

Section: Purification and Separationmentioning

confidence: 99%

“…Inflammation is a reaction of the body to pathogenic factors and their damaging effects, which can have a major or minor impact on the body; if it occurs in the body, it may develop into a chronic disease, and if inflammation is present for a long time, then the damage to the body is undoubtedly enormous. The rational use of polysaccharides in the treatment of inflammation can significantly reduce the expression of cellular inflammation‐related factors and reduce the body's immune stress response (Galli et al, 2008; Xiao et al, 2021; J. Xu et al, 2019). Gao et al (1997) isolated four acidic heteropolysaccharides (T2a–T2d) from White jellyfungus , and experimental studies proved that WJP could induce human monocytes to produce IL‐1, IL‐6, and TNF‐α (Gao et al, 1997).…”

Section: Activitymentioning

confidence: 99%

Extraction, isolation, purification, derivatization, bioactivity, structure–activity relationship, and application of polysaccharides from White jellyfungus

Lin

Huang

2022

Biotech & Bioengineering

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White jellyfungus is one of the most popular nutritional supplements. The polysaccharide (WJP) is an important active component of White jellyfungus, it not only has a variety of biological activities but also is nontoxic to humans. So, many scholars have carried out different research on WJP. However, the lack of a detailed summary of WJP limits the scale of industrial development of WJP.Herein, the research progress of WJP in extraction, isolation, structure, derivatization, and structure-activity relationship was reviewed. Different extraction methods were compared, the activity and application of WJP were summarized, and the structure-activity relationship of WJP was emphasized to provide effective theoretical support for improving the utilization of WJP and promoting the application of related industries.

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Tremella fuciformis polysaccharides ameliorated ulcerative colitis via inhibiting inflammation and enhancing intestinal epithelial barrier function

Cited by 67 publications

References 35 publications

Tremella fuciformis polysaccharide reduces obesity in high-fat diet-fed mice by modulation of gut microbiota

Tremella fuciformis polysaccharide reduces obesity in high-fat diet-fed mice by modulation of gut microbiota

Capparis spinosa Alleviates DSS-Induced Ulcerative Colitis via Regulation of the Gut Microbiota and Oxidative Stress

Extraction, isolation, purification, derivatization, bioactivity, structure–activity relationship, and application of polysaccharides from White jellyfungus

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