Trends in combined radio-chemotherapy for locally advanced rectal cancer: a survey among radiation oncology centers of Sicily region on behalf of AIRO

Spatola, Corrado; Privitera, Giuseppe; Milazzotto, Roberto; Tocco, Alessandra; Acquaviva, Grazia; Marletta, F; Marino, Lorenza; Grazia, Alfio Di; Salvo, R.; Cartia, G.; Platania, A; Molino, Laura; Santacaterina, Anna; Raso, Marilena Mattace; Frosina, P.; Ianni, Roberto; Bono, Michele; Liardo, L.; Bonanno, Santo; Paglia, Leonarda La; Federico, Manuela; Fazio, Ivan; Mortellaro, Gianluca; Ferrera, Giuseppe; Tripoli, Antonella; Evangelista, G.; Daidone, Antonino; Biti, Giampaolo; Badalamenti, Matteo; Ognibene, Lucia; Cacciola, Alberto; Parisi, Silvana; Pergolizzi, Stefano

doi:10.1007/s11547-019-01007-x

Cited by 9 publications

(6 citation statements)

References 32 publications

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“…GI toxicity is frequently observed also after ChT [ 67 ]. Enteritis is often diffuse or prevailing in the distal ileum, while gastritis and duodenitis are less common (Fig.…”

Section: Imaging Findingsmentioning

confidence: 99%

Imaging side effects and complications of chemotherapy and radiation therapy: a pictorial review from head to toe

et al. 2021

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Newer biologic drugs and immunomodulatory agents, as well as more tolerated and effective radiation therapy schemes, have reduced treatment toxicity in oncology patients. However, although imaging assessment of tumor response is adapting to atypical responses like tumor flare, expected changes and complications of chemo/radiotherapy are still routinely encountered in post-treatment imaging examinations. Radiologists must be aware of old and newer therapeutic options and related side effects or complications to avoid a misinterpretation of imaging findings. Further, advancements in oncology research have increased life expectancy of patients as well as the frequency of long-term therapy-related side effects that once could not be observed. This pictorial will help radiologists tasked to detect therapy-related complications and to differentiate expected changes of normal tissues from tumor relapse.

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“…GI toxicity is frequently observed also after ChT [ 67 ]. Enteritis is often diffuse or prevailing in the distal ileum, while gastritis and duodenitis are less common (Fig.…”

Section: Imaging Findingsmentioning

confidence: 99%

Imaging side effects and complications of chemotherapy and radiation therapy: a pictorial review from head to toe

et al. 2021

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“…Rectal cancer (RC) accounts for one third of all colorectal cancers and is one of the leading causes of cancer death in the Western world in both sexes [25,[152][153][154]. IN actual fact, neoadjuvant chemo-radiotherapy (nCRT) followed by total meso-rectal excision (TME) is the gold-standard treatment for patients with locally advanced rectal cancer (LARC) [155], as it increases PFS and allows, at the same time, a less invasive surgery with a lower frequency of complications, albeit its effects on overall survival (OS) is still to be proven [156,157]; in a significant percentage of patients, nCRT led to a pathological complete response (pCR) [158][159][160], a concept that has led to new conservative strategies ("watch-and-wait" or local excision) that could be attempted in order to avoid invasive surgery with the risk of major complications and a possible worsening of the quality of life [161].…”

Section: Texture Analysis and Prognosis-focus On Rectal Cancermentioning

confidence: 99%

Radiomics as a New Frontier of Imaging for Cancer Prognosis: A Narrative Review

et al. 2021

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The evaluation of the efficacy of different therapies is of paramount importance for the patients and the clinicians in oncology, and it is usually possible by performing imaging investigations that are interpreted, taking in consideration different response evaluation criteria. In the last decade, texture analysis (TA) has been developed in order to help the radiologist to quantify and identify parameters related to tumor heterogeneity, which cannot be appreciated by the naked eye, that can be correlated with different endpoints, including cancer prognosis. The aim of this work is to analyze the impact of texture in the prediction of response and in prognosis stratification in oncology, taking into consideration different pathologies (lung cancer, breast cancer, gastric cancer, hepatic cancer, rectal cancer). Key references were derived from a PubMed query. Hand searching and clinicaltrials.gov were also used. This paper contains a narrative report and a critical discussion of radiomics approaches related to cancer prognosis in different fields of diseases.

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“…Adequately predicting the response to neoadjuvant chemoradiotherapy (nCRT) in rectal cancer represents a key factor in order to achieve a fully personalized treatment approach, especially in the case of locally advanced disease presentation, which constitute a well-established indication for radiation therapy [127]. The identification of biomarkers able to predict patients' outcomes (i.e., response to nCRT) currently represents a priority in the radiotherapy research landscape, and imaging-derived response predictors are a topic of active investigation [128][129][130][131][132][133].…”

Section: Texture Analysis In Neoadjuvant Radiotherapy-a Focus On Rectal Cancermentioning

confidence: 99%

Radiomics in the Setting of Neoadjuvant Radiotherapy: A New Approach for Tailored Treatment

Nardone

Boldrini

Grassi

et al. 2021

Cancers

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Introduction: Neoadjuvant radiotherapy is currently used mainly in locally advanced rectal cancer and sarcoma and in a subset of non-small cell lung cancer and esophageal cancer, whereas in other diseases it is under investigation. The evaluation of the efficacy of the induction strategy is made possible by performing imaging investigations before and after the neoadjuvant therapy and is usually challenging. In the last decade, texture analysis (TA) has been developed to help the radiologist to quantify and identify the parameters related to tumor heterogeneity, which cannot be appreciated by the naked eye. The aim of this narrative is to review the impact of TA on the prediction of response to neoadjuvant radiotherapy and or chemoradiotherapy. Materials and Methods: Key references were derived from a PubMed query. Hand searching and ClinicalTrials.gov were also used. Results: This paper contains a narrative report and a critical discussion of radiomics approaches in different fields of neoadjuvant radiotherapy, including esophageal cancer, lung cancer, sarcoma, and rectal cancer. Conclusions: Radiomics can shed a light on the setting of neoadjuvant therapies that can be used to tailor subsequent approaches or even to avoid surgery in the future. At the same, these results need to be validated in prospective and multicenter trials.

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Trends in combined radio-chemotherapy for locally advanced rectal cancer: a survey among radiation oncology centers of Sicily region on behalf of AIRO

Cited by 9 publications

References 32 publications

Imaging side effects and complications of chemotherapy and radiation therapy: a pictorial review from head to toe

Imaging side effects and complications of chemotherapy and radiation therapy: a pictorial review from head to toe

Radiomics as a New Frontier of Imaging for Cancer Prognosis: A Narrative Review

Radiomics in the Setting of Neoadjuvant Radiotherapy: A New Approach for Tailored Treatment

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