Trends in incidence and survival outcome of epithelial ovarian cancer: 30-year national population-based registry in Taiwan

Abstract

ObjectiveTo investigate the changes of incidence and prognosis of epithelial ovarian cancer in thirty years in Taiwan.MethodsThe databases of women with epithelial ovarian cancer during the period from 1979 to 2008 were retrieved from the National Cancer Registration System of Taiwan. The incidence and prognosis of these patients were analyzed.ResultsTotally 9,491 patients were included in the study. The age-adjusted incidences of epithelial ovarian cancer were 1.01, 1.37, 2.37, 3.24, 4.18, and 6.33 per 100,000 person-years, respectively, in every 5-year period from 1979 to 2008. The age-specific incidence rates increased especially in serous, endometrioid and clear cell carcinoma, and the age of diagnosis decreased from sixty to fifty years old in the three decades. Patients with mucinous, endometrioid, or clear cell carcinoma had better long-term survival than patients with serous carcinoma (log rank test, p<0.001). Patients with undifferentiated carcinoma or carcinosarcoma had poorer survival than those with serous carcinoma (log rank test, p<0.001). The mortality risk of age at diagnosis of 30-39 was significantly higher than that of age of 70 years or more (test for trend, p<0.001). The mortality risk decreased from the period of 1996-1999 (hazard ratio [HR], 0.90; p=0.054) to the period after 2000 (HR, 0.74; p<0.001) as compared with that from the period of 1991-1995.ConclusionAn increasing incidence and decreasing age of diagnosis in epithelial ovarian cancer patients were noted. Histological type, age of diagnosis, and treatment period were important prognostic factors for epithelial ovarian carcinoma.

Role of Aurora-A in Ovarian Cancer: A Meta-Analysis

“…The incidence of ovarian cancer increases with age and is most prevalent in the sixth and seventh decades of life with a 5-year survival rate of only 25% [2,3]. Although epithelial ovarian cancer has been managed with surgical resection and chemotherapy, most patients develop a recurrence of the disease.…”

Three years survival rate of epithelial ovarian cancer patients in Dr. Kariadi Hospital, Semarang, Central Java

“…17 The results of this study were similar to other studies which suggested that patients with mucinous and clear cell type of histopathology had better survival rate than the patients with serous type. 18 The differences between the theoretical results with the results of this study could possibly happen due to lack homogenity of the sample. The sample in this study used all stages of epithelial ovarian cancer.Maybe the results will be more accurate in the same stage, for example, only using samples of stage III.…”

Cancer survival in Qidong between 1972 and 2011: A population-based analysis

“…Table IV shows the 5-year observed and relative survival by age group (15-34, 35-44, 45-54, 55-64, 65-74, and 75+) for all the major cancer sites. Relatively higher survival rates were observed in younger patients (15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44) compared with older patients (65-74, 75+), particularly for sites including the stomach, lung, pancreas, B and CNS, blood (NHL) and cervix. Cancer of the oesophagus, female breast and bladder had higher survival in middle-aged groups (45)(46)(47)(48)(49)(50)(51)(52)(53)(54)(55)(56)(57)(58)(59)…”

“…Previous studies have reported on population-based cancer survival in Shanghai (38) and Zhejiang (39); however, these studies primarily focused on a certain or some cancer sites over a short time period. In Taiwan, the survival rates for epithelial ovarian cancer and uterine cancer were reported based upon data from a population-based registry (40,41).…”