Trends in Risk Factors and Etiology of 606 Cases of Infective Endocarditis Over 23 Years (1984-2006) in Slovakia

Abstract

The aim of this study was to assess trends in risk factors, etiology, outcome and treatment strategies for endocarditis over 23 years in Slovakia. A prospective survey of 606 cases of infective endocarditis (IE) was conducted from 1984-2006. Rheumatic fever as well as previous dental surgery showed decreasing trends within the last 23 years. Also embolic complications of IE declined along with increasing rates of surgically treated patients. No significant changes in etiology were detected apart from the fact that culture-negative endocarditis increased from 10.7% to 55.4% between 1998-2001. Surgically treated patients increased from 22.7% (1984-1990) to 50.1% (2002-2006) and mortality dramatically decreased from 26.7% (1984-1990) to 5.3% (2002-2006). Staphylococcus aureus and coagulase-negative staphylococci were the leading causes (22.4% - 48%) followed by viridans streptococci (12.2%-18.2%) were a relatively stable trend over 23 years of IE in Slovakia.

Changing profile of infective endocarditis in patients hospitalised in a tertiary Czech hospital from 2000 to 2013

“…K dispozici máme dokonce epidemiologickou studii z České republiky publikovanou v roce 2012, která ukazuje nárůst v incidenci IE na 3,4 případu na 100 000 obyvatel [6]. Až na ojedinělé výjimky [5] potvrzují trendy k rostoucímu zastoupení IE chlopenních náhrad a implantovaných přístrojů také další práce z českého a slovenského prostředí [4,6,14]. Naše nálezy jsou tedy v souladu s uvedenými pozorováními.…”

Characteristics, management, and outcome of infective endocarditis in the Czech Republic: prospective data from the ESC EORP EURO-ENDO registry

“…Despite continuous advances in diagnostics and therapeutic management, infective endocarditis (IE) remains a life-threating disease (1). Based on fi ndings from both individual institutional experiences and large, multi-centre studies, a considerable variability in the clinical features of infective endocarditis has been reported (2)(3)(4)(5)(6). Only limited data have been published on this topic with the aim to provide a current contemporary profi le of the disease in the Czech Republic (6)(7)(8).…”

“…Several important factors garnered attention in the recent studies from the region, reporting an increasing incidence of the disease in elderly, change in the predisposing factors, marked shift in aetiology of IE (3,6,7). Nonetheless, these studies suffered from major limitations mainly due to retrospective analysis, small number of recruited patients, and most importantly representing only single or dual centre experience.…”

(Infective endocarditis in a cardiovascular centre with no cardiac surgery unit: epidemiological changes and mortality predictors)

“…21 Prokázali jsme výrazně vyšší mortalitu pacientů s PVE, což je v souladu s jinými pracemi. 14,16,17,22 Průměrná doba od počátku symptomů do stanovení diagnózy činila osm dní. Mezi nejčastějšími důvody diagnostického prodlení byla obtížná interpretace nespecifi ckých symptomů, obtíže s identifi kací původců nebo prodlení z důvodu pozdní návštěvy lékaře aj.…”