Trenimon-induced chromosomal damage in bone-marrow cells of six mammalian species, evaluated by the micronucleus test

The micronucleus test: examples of application to marine ecology

“…'Micronucleus tests' to evaluate chromoson~al damage were performed in the early 1970's by Bo! !er & Schmid (1970), Matter & Schmid (1971) and Heddle (1973) in mammalian cells. Since then several studies performed in plants and in different animals both in vivo and in vitro, as well as in human bone marrow cells and blood lymphocytes, have shown the test to be a very sensitive indicator of chromosomal damage (see review by Jenssen 1982).…”

Novel Approaches in Genetic Toxicology of Pesticides by Applying Fluorescent in Situ Hybridization Technique

“…It took over the primacy of being the most relevant biomarker of effect from chromosomal aberrations (Cavallo et al, 2009). Micronuclei as manifestations of adverse effect of physical and chemical agents on cell genome have been known for more than 40 years (Matter & Schmid, 1971). They are small chromatin structures visible in cytoplasm of interphase cells, with maximum of 1/3 of nuclear diameter in size.…”

Numerical dosimetric calculations for in vitro field expositions in the THz frequency range

“…Two different exposure times of 2 h and 8 h are chosen. The comet assay is used as biological end point for strand breaks (Singh, 1988), whereas the micronucleus test is chosen to search for possible aneugenic and clastogenic effects (Matter and Schmid, 1971). The validity of the results is guaranteed by positive controls, sham exposition experiments and a blinded experimental procedure.…”