“…[5,12] In general, the ventilation multiplier Considering that Stoffenmanager and the ART are classified as higher tier exposure assessment tools, [5,17] both are recommended by ECHA for regulatory exposure assessment, [22] and that Stoffenmanager has alone over 32,000 users, [3] the errors is general ventilation multipliers should not be ignored. The studies [5,[22][23][24][25][26][27][28][29][30] concerning the tools evaluation, validation, applicability, and sensitivity analysis should be revised and corrected before the tools are used in regulatory risk assessment or before implementing them to tools combining different exposure models, such as a Translation Tool to Support the Use of Regulatory Occupational Exposure Models (TREXMO; [31] see also letter to the editors, [31][32][33] ) SUN decision support system, [34] or risk governance tools developed in caLIBERAte. [35] In our opinion, the regulatory exposure modeling should rely only on mathematical models following general physical principles, such as conservation of mass, rather than conceptual models based on non-physical models or exposure determinants.…”