Trichinella spiralis—A potential anti-tumor agent

Wang, X.L.; Fu, Bao‐Quan; Yang, Shuang; Wu, Xiuping; Cui, Guimei; Liu, M.F.; Zhao, Ying; Yu, Yang; Liu, X.Y.; Deng, Hao; Chen, Q.J.

doi:10.1016/j.vetpar.2008.10.052

Cited by 46 publications

(59 citation statements)

References 14 publications

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“…It has been experimentally demonstrated that helminths could provide the protection or ameliorate the clinical signs of a number of diseases, such as autoimmune diseases [4–6], allergic inflammation [7–9], and even tumours [10, 11]. Among the other functions, products of helminth parasites have the capacity to modify signal transduction, resulting either in the host cell proliferation or cell death [12–14].…”

Section: Introductionmentioning

confidence: 99%

“…to affect tumour development, little has been done in this field of research. Only recently it was shown that T. spiralis infection, as well as treatment of mice with a mixture of crude extracts from T. spiralis adult parasites and newborn larvae, can slow down or even inhibit the progression of tumours induced by different tumour cell lines [10]. The same group of authors have found that adult crude extract had an in vitro anti-proliferative effect on the hepatoma cell line H7402.…”

Section: Introductionmentioning

confidence: 99%

“…Investigations of substances that can affect the apoptotic process in melanoma would be a valuable contribution to finding new therapeutic approaches for this disease. From the modest level of data available in the field it appears that all three stages of T. spiralis life cycle contain components that are able to control malignancy [10, 15, 19]. On the other hand, it was shown that this parasite could tame autoimmune disease [6], implying the involvement of completely different mechanisms that create a tolerogenic environment [25, 26].…”

Section: Introductionmentioning

confidence: 99%

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Experimental immunology Necrosis and apoptosis in Trichinella spiralis -mediated tumour reduction

Vasilev¹,

Ilić²,

Gruden-Movsesijan³

et al. 2015

cejoi

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It is known that infection with different pathogens, including helminths, can alter the progression of malignant or other diseases. We studied the effect of chronic Trichinella spiralis infection or muscle larvae excretory-secretory (ES L1) antigens on the malignant tumour growth in the mouse melanoma model system in vivo and in vitro. Our results confirmed that chronic infection with T. spiralis possesses the capacity to slow down the progression of tumour growth, resulting in an impressive reduction in tumour size. We found that the phenomenon could, at least partially, be related to a lower level of tumour necrosis compared to necrosis present in control animals with progressive malignancy course. An increased apoptotic potential among the low percentage of cells within the total tumour cell number in vivo was also observed. ES L1 antigen, as a parasitic product that is released during the chronic phase of infection, reduced the survival and slightly, but significantly increased the apoptosis level of melanoma cells in vitro. Our results imply that powerful Trichinella anti-malignance capacity does not rely only on necrosis and apoptosis but other mechanisms through which infection or parasite products manipulate the tumor establishment and expansion should be considered.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Experimental immunology Necrosis and apoptosis in Trichinella spiralis -mediated tumour reduction

Vasilev¹,

Ilić²,

Gruden-Movsesijan³

et al. 2015

cejoi

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“…It was in the second part of the previous century that T. spiralis has been recognized for the first time as a nematode that can negatively influence a tumor growth and prolong the life span [147, 148]. However, the observed potential of Trichinella to affect tumor development was not investigated until recently, when Wang et al [13] showed that T. spiralis infection as well as treatment of mice with mixture of crude extracts from adult parasite and newborn larvae can slow down or even inhibits the progression of tumors induced by different tumor cell lines. Also, the authors demonstrated strong antiproliferative and high proapoptotic influence of T. spiralis antigens on two different cell lines in vitro (K562 and H7402).…”

Section: T Spiralis Immunomodulation Of Autoimmunity Allergy Anmentioning

confidence: 99%

“…Immune events orchestrated by Th2 and Treg cell types can successfully modulate the immune response of the host [10]. This parasite has evolved to suppress the host immune response against itself in order to survive [2], but it also suppresses immune responses to autoantigens and allergens [11, 12] and prevents or attenuates malignant cell development and expansion [13]. This review summarizes the current knowledge on the mechanisms of immunomodulation engaged by this nematode through the ES L1.…”

Section: Introductionmentioning

confidence: 99%

Secretory Products ofTrichinella spiralisMuscle Larvae and Immunomodulation: Implication for Autoimmune Diseases, Allergies, and Malignancies

Sofronić-Milosavljević

Ilić

Pinelli

et al. 2015

Journal of Immunology Research

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Trichinella spiralis has the unique ability to make itself “at home” by creating and hiding in a new type of cell in the host body that is the nurse cell. From this immunologically privileged place, the parasite orchestrates a long-lasting molecular cross talk with the host through muscle larvae excretory-secretory products (ES L1). Those products can successfully modulate parasite-specific immune responses as well as responses to unrelated antigens (either self or nonself in origin), providing an anti-inflammatory milieu and maintaining homeostasis. It is clear, based on the findings from animal model studies, that T. spiralis and its products induce an immunomodulatory network (which encompasses Th2- and Treg-type responses) that may allow the host to deal with various hyperimmune-associated disorders as well as tumor growth, although the latter still remains unclear. This review focuses on studies of the molecules released by T. spiralis, their interaction with pattern recognition receptors on antigen presenting cells, and subsequently provoked responses. This paper also addresses the immunomodulatory properties of ES L1 molecules and how the induced immunomodulation influences the course of different experimental inflammatory and malignant diseases.

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