Trichosporon beigelii Pneumonia in Patients With Hematologic Malignancies

Tashiro, Takayoshi; Nagai, Hirokazu; Nagaoka, Hiroshi; Goto, Yoichiro; Kamberi, Perparim; Nasu, Masaru

doi:10.1378/chest.108.1.190

Cited by 53 publications

(40 citation statements)

References 22 publications

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“…While resistance to AMB is common among Trichosporon species (9,16,28,42,45,46), this is only the second report, to the authors' knowledge, of strains with reduced susceptibilities to AMB, flucytosine, and azoles. Although T. cutaneum isolates recovered from nine patients with fungemia were recently reported to be resistant to antifungal antibiotics, only one was resistant to both AMB and azoles (22).…”

Section: Discussionmentioning

confidence: 80%

Multidrug-Resistant Trichosporon asahii Infection of Nongranulocytopenic Patients in Three Intensive Care Units

et al. 2001

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Trichosporon asahii (Trichosporon beigelii) infections are rare but have been associated with a wide spectrum of clinical manifestations, ranging from superficial involvement in immunocompetent individuals to severe systemic disease in immunocompromised patients. We report on the recent recovery of T. asahii isolates with reduced susceptibility in vitro to amphotericin B (AMB), flucytosine, and azoles from six nongranulocytopenic patients who exhibited risk factors and who developed either superficial infections (four individuals) or invasive infections (two individuals) while in intensive care units. The latter two patients responded clinically and microbiologically to AMB treatment. All six isolates were closely related according to random amplified polymorphic DNA studies and showed 71% similarity by amplified fragment length polymorphism analysis, suggesting a common nosocomial origin. We also review the literature pertaining to T. asahii infections and discuss the salient characteristics of this fungus and recent taxonomic proposals for the genus.Trichosporon infections are associated with a wide spectrum of clinical manifestations, ranging from superficial cutaneous involvement in immunocompetent individuals to severe systemic disease in immunocompromised patients (9, 44). Trichosporon asahii (Trichosporon beigelii) has increasingly been described as an opportunistic pathogen involved in disseminated infections in patients with profound granulocytopenia (9,11,26). Less commonly reported risk factors associated with infections caused by this agent include treatment with immunosuppressive drugs, transplantation, AIDS, extensive burns, and the presence of implanted prosthetic devices (9,11,14,20,24,27,29).Trichosporon species were the most common non-Candida cause of fungemia at a national cancer institute (23). Disseminated Trichosporon infections in immunocompromised patients are frequently fatal, despite therapy with amphotericin B (AMB) (9,44,46). This antifungal agent has been shown to have a limited in vitro effect against Trichosporon species. In contrast, azoles have been demonstrated to have in vitro activity against members of this genus and their use has been associated with favorable responses in animal models (2,3,9,27,31,32,45,46).We report on the recent recovery of T. asahii isolates resistant in vitro to AMB and azoles from six nongranulocytopenic patients who developed either invasive or superficial infections while hospitalized in different intensive care units (ICUs). We describe the demographic and major clinical characteristics of these patients and review the literature pertaining to T. asahii infections. Results from molecular biology-based studies based on random amplified polymorphic DNA (RAPD) and amplified fragment length polymorphism (AFLP) analyses suggest that the isolates recovered from specimens of these six patients were closely related. In addition, we discuss the salient characteristics of this fungus and recent taxonomic proposals for the genus. MATERIALS AND METHODSCase re...

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Section: Discussionmentioning

confidence: 80%

Multidrug-Resistant Trichosporon asahii Infection of Nongranulocytopenic Patients in Three Intensive Care Units

et al. 2001

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“…Thus, it is suggested that these fungi can cause hypersensitivity pneumonitis as allergens and deepseated trichosporonosis as pathogens, depending on the host's immunological status [7]. It is thought that these fungi enter the body via areas where indwelling vascular catheters and drainage tubes are inserted, via damaged skin areas in burn patients and by microbial translocation from the intestinal mucosa [8].…”

Section: Introductionmentioning

confidence: 99%

Increased release of glucuronoxylomannan antigen and induced phenotypic changes in Trichosporon asahii by repeated passage in mice

Karashima

Yamakami

Yamagata

et al. 2002

Journal of Medical Microbiology

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“…richosporon asahii is an important opportunistic pathogenic fungus which exists widely in natural conditions (4,12) and can cause many diseases, such as superficial skin infections (7,12), summer hypersensitivity pneumonia (10,13), and disseminated infections of internal organs (3,6,8,14), in humans.…”

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confidence: 99%

Draft Genome Sequence of CBS 2479, the Standard Type Strain of Trichosporon asahii

Yang

Zhu

et al. 2012

Eukaryot Cell

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bTrichosporon asahii is one of the important opportunistic pathogenic fungi. Here, we first report the draft nuclear chromosome genome sequence and mitochondrial genome sequence of T. asahii CBS 2479, which is a standard strain of T. asahii that was isolated from a progressive psoriatic lesion. COG analysis predicted that 3,131 genes were assigned to 23 functional categories and that 628 genes were predicted to have a general function.

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Trichosporon beigelii Pneumonia in Patients With Hematologic Malignancies

Cited by 53 publications

References 22 publications

Multidrug-Resistant Trichosporon asahii Infection of Nongranulocytopenic Patients in Three Intensive Care Units

Multidrug-Resistant Trichosporon asahii Infection of Nongranulocytopenic Patients in Three Intensive Care Units

Increased release of glucuronoxylomannan antigen and induced phenotypic changes in Trichosporon asahii by repeated passage in mice

Draft Genome Sequence of CBS 2479, the Standard Type Strain of Trichosporon asahii

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