"Triiodothyronine (T3) Toxicosis"

Ivy, Horace K.

doi:10.1001/archinte.1971.00310220037002

Cited by 13 publications

(5 citation statements)

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“…We believe that our patients exhibited true T3 toxicosis although we recognize that the T3 levels in our subjects are not as high as may be found in adults with T3 toxicosis (13,15,25), and that normal values for serum T3 are higher in children than adults (23). In one reported paediatric case, the T3 level was 1200 ng/ml (17).…”

Section: Discussionmentioning

confidence: 66%

“…The recent development of a simple and rapid immunoassay for triiodothyronine (T3) in serum (7,8,9) has opened interest in the contribution of this hormone in thyrotoxic states. T3 toxicity in the presence of normal serum thyroxine (T4), has been well documented in adults (13,15,25). In the paediatric literature, however, only isolated cases have been reported (17,22), suggesting that this disorder may be less frequent in childhood.…”

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confidence: 99%

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T3 Toxicosis in Children

1977

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Triiodothyronine (T3) toxicity has been well documented in adults, but only isolated cases have been reported in children. Two girls presented with firm goitres and overt hyperthyroidism. In each patient, total serum thyroxine (T4) values by competitive protein binding were normal, however total T3 values by radioimmunoassay were elevated. One patient had Graves' disease, the second patient had Hashimoto's disease which has been only infrequently associated with T3 toxicity in adults. Both patients responded to therapy with propylthiouracil. The mechanisms by which T3 is preferentially secreted in thyrotoxic states in man are poorly understood, but iodine deficiency and poor iodination of thyroglobulin may be important factors.

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Section: Discussionmentioning

confidence: 66%

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confidence: 99%

T3 Toxicosis in Children

1977

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“…The response to methimazole is also in favour of Graves' disease. T3 toxicosis has also been observed in patients with disseminated follicular carcinoma of the thyroid (Sung and Cavalieri, 1973) and Hashimoto's thyroiditis (Ivy, Wahner and Gorman, 1971). Since an hemiagenetic thyroid can also be involved in different thyroid diseases.…”

Section: Discussionmentioning

confidence: 99%

Hemiagenesis of the thyroid gland and T3 hyperthyroidism

Matsumura

Dib

Russo

et al. 1982

Postgraduate Medical Journal

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“…This would suggest that there is still an element of iodine de¬ ficiency within the group as this is the major factor favouring T3 production, T3 being the more active hormone and requiring less iodine (Hollander et al 1971;Ivy et al 1971;Gréer 1972). This would suggest that there is still an element of iodine de¬ ficiency within the group as this is the major factor favouring T3 production, T3 being the more active hormone and requiring less iodine (Hollander et al 1971;Ivy et al 1971;Gréer 1972).…”

Section: Discussionmentioning

confidence: 99%

Sporadic Non-Toxic Goitre

Parker

Ratcliffe

Alexander

1977

Acta Endocrinologica

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Thirty-six patients with non-toxic goitre were reviewed after a mean period of 13 years. Initially 19 patients were iodine deficient (Group I) and 17 had normal plasma inorganic iodine (Group II). In general the iodine deficient patients had larger goitres, developed more complications (26 % became hyperthyroid, hypothyroid or required partial thyroidectomy), and required more treatment. There were marked changes in thyroid function tests. In both groups thyroid uptake fell and PII rose though the final PII remained significantly lower in Group I patients. Thyroid and renal iodide clearance fell significantly in Group I patients only. In both groups the final mean total serum T3 levels were abnormally elevated whereas the mean PBI levels did not change significantly during the period of study and the final mean total T4 concentrations were normal.All goitres became smaller and there were no complications in patients whose goitre became impalpable. No cases of malignancy and no postoperative recurrences of goitre were observed. It is suggested that the incidence of complications in those patients who persist with palpable goitres is sufficient to merit follow-up of this group.

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"Triiodothyronine (T3) Toxicosis"

Cited by 13 publications

References 0 publications

T3 Toxicosis in Children

T3 Toxicosis in Children

Hemiagenesis of the thyroid gland and T3 hyperthyroidism

Sporadic Non-Toxic Goitre

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