Trimetallic Pd@Au@Pt nanocomposites platform on -COOH terminated reduced graphene oxide for highly sensitive CEA and PSA biomarkers detection

Barman, Sharat Chandra; Hossain, Faruk; Yoon, Hyosang; Park, Jae Young

doi:10.1016/j.bios.2017.08.045

Cited by 122 publications

(55 citation statements)

References 43 publications

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“…Moreover, the aqueous environment may damage nanomaterials, which leads to biosensors' error or disability. Finally, some of NPs or 2D materials in the composite material inhibit or interact with the biomarker, which affects the activity of biomarker or specific binding, resulting in a discrepancy of actual concentration [ 28 , 34 , 35 , 39 , 119 , 187 , 190 ].…”

Section: Discussionmentioning

confidence: 99%

“…As a catalyst, Cu not only impacts the growth density of CNT but also provides conductive pathways to accelerate electron transfer between the redox probe and the surface of the electrode [ 42 ]. Taking advantage of more electroactive sites and a larger surface area for biomarker captured, Barman et al developed a CEA and PSA biosensor by using Pd, Au, and Pt nanocomposites which were immobilized onto the electrodes decorated by rGO, which is shown in Figure 3(c) [ 28 ]. Wu et al developed a label-free photoelectrochemical sensor for CEA detection, which was fabricated by using 2D graphitic carbon nitride nanosheets (g-C 3 N 4 ) with Zn 0.1 Cd 0.9 S nanocrystals.…”

Section: Electrochemical Biomarker Sensorsmentioning

confidence: 99%

“…(a) 2D material GO and aptamer modified on the GCE, reproduced from Yang et al [ 26 ]. (b) Graphene-based 2D material modified chip by wetting transfer, reproduced from Delle et al [ 27 ], and (c) rGO and nanocomposites Pd, Au, and Pt immobilized on the electrode, reproduced from Barman et al [ 28 ] with their permissions.…”

Section: Figurementioning

confidence: 99%

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Recent Progress of Biomarker Detection Sensors

Liu

Cui

2020

Research

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Early cancer diagnosis and treatment are crucial research fields of human health. One method that has proven efficient is biomarker detection which can provide real-time and accurate biological information for early diagnosis. This review presents several biomarker sensors based on electrochemistry, surface plasmon resonance (SPR), nanowires, other nanostructures, and, most recently, metamaterials which have also shown their mechanisms and prospects in application in recent years. Compared with previous reviews, electrochemistry-based biomarker sensors have been classified into three strategies according to their optimizing methods in this review. This makes it more convenient for researchers to find a specific fabrication method to improve the performance of their sensors. Besides that, as microfabrication technologies have improved and novel materials are explored, some novel biomarker sensors—such as nanowire-based and metamaterial-based biomarker sensors—have also been investigated and summarized in this review, which can exhibit ultrahigh resolution, sensitivity, and limit of detection (LoD) in a more complex detection environment. The purpose of this review is to understand the present by reviewing the past. Researchers can break through bottlenecks of existing biomarker sensors by reviewing previous works and finally meet the various complex detection needs for the early diagnosis of human cancer.

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Section: Discussionmentioning

confidence: 99%

Section: Electrochemical Biomarker Sensorsmentioning

confidence: 99%

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Recent Progress of Biomarker Detection Sensors

Liu

Cui

2020

Research

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“…It was applied as electrochemical immunosensor nanoplatforms for fast and sensitive detecting PSA and carcinoembryonic antigen (CEA) biomarkers ( Figure 11 ). After treatment, the anti-PSA and anti-CEA can be immobilized separately on two diverse PSA and CEA antibody-conjugated PdAuPt/COOH-rGO platforms [ 119 ].…”

Section: Applications Of Trimetallic Npsmentioning

confidence: 99%

“… Schematic illustrations of the ( a ) sensing platform, ( b ) preparation sequence of trimetallic PdAuPt/COOH-rGO immuno-sensor for the CEA/PSA detection; photomicrograph of the ( c ) advanced immunosensors. Reproduced from [ 119 ], with permission from Elsevier, 2018. …”

Section: Figures Scheme and Tablementioning

confidence: 99%

Trimetallic Nanoparticles: Greener Synthesis and Their Applications

et al. 2020

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Nanoparticles (NPs) and multifunctional nano-sized materials have significant applications in diverse fields, namely catalysis, sensors, optics, solar energy conversion, cancer therapy/diagnosis, and bioimaging. Trimetallic NPs have found unique catalytic, active food packaging, biomedical, antimicrobial, and sensing applications; they preserve an ever-superior level of catalytic activities and selectivity compared to monometallic and bimetallic nanomaterials. Due to these important applications, a variety of preparation routes, including hydrothermal, microemulsion, selective catalytic reduction, co-precipitation, and microwave-assisted methodologies have been reported for the syntheses of these nanomaterials. As the fabrication of nanomaterials using physicochemical methods often have hazardous and toxic impacts on the environment, there is a vital need to design innovative and well-organized eco-friendly, sustainable, and greener synthetic protocols for their assembly, by applying safer, renewable, and inexpensive materials. In this review, noteworthy recent advancements relating to the applications of trimetallic NPs and nanocomposites comprising these NPs are underscored as well as their eco-friendly and sustainable synthetic preparative options.

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