Trimethoprim-induced augmentation of human natural killer activity in vitro

Matheson, David S.; Wilson, Robert; Green, Bridget

doi:10.1016/0162-3109(82)90027-3

Cited by 7 publications

(5 citation statements)

References 9 publications

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“…The tumor growth curve was determined by measuring tumor sizes according to the tumor volume. Figure 7B indicates the tumor growth rates in mice treated with free CP, MIL-100(Fe), and MIL-100(Fe)/CP/CS, which are 36 They reported that D-glucosamine can enhance natural killer-cell activity. 36,37 Figure 8c shows tumor cells treated with MIL-100(Fe)/CP with a moderate level of tumor cell necrosis.…”

mentioning

confidence: 82%

“…Figure 7B indicates the tumor growth rates in mice treated with free CP, MIL-100(Fe), and MIL-100(Fe)/CP/CS, which are 36 They reported that D-glucosamine can enhance natural killer-cell activity. 36,37 Figure 8c shows tumor cells treated with MIL-100(Fe)/CP with a moderate level of tumor cell necrosis. Furthermore, no apparent tumor destruction was observed in the control group, as shown in Figure 8a.…”

mentioning

confidence: 82%

“…According to the in vitro investigation, the biocompatible nature of chitosan enhances the interaction between the MIL-100(Fe) containing drug and cells. Additionally, the findings of Matheson et al indicated the tumor growth inhibitory effect of polysaccharides against mouse tumors . They reported that d -glucosamine can enhance natural killer-cell activity. , Figure c shows tumor cells treated with MIL-100(Fe)/CP with a moderate level of tumor cell necrosis.…”

mentioning

confidence: 90%

“…Additionally, the findings of Matheson et al indicated the tumor growth inhibitory effect of polysaccharides against mouse tumors . They reported that d -glucosamine can enhance natural killer-cell activity. , Figure c shows tumor cells treated with MIL-100(Fe)/CP with a moderate level of tumor cell necrosis. Furthermore, no apparent tumor destruction was observed in the control group, as shown in Figure a.…”

mentioning

confidence: 90%

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Chitosan-Coated MIL-100(Fe) as an Anticancer Drug Carrier: Theoretical and Experimental Investigation

Tohidi

Aghaie-Khafri

2023

ACS Med. Chem. Lett.

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MIL-100(Fe) was synthesized under biofriendly conditions at room temperature and pressure using iron(II) chloride as the source of iron, and it was coated with chitosan (CS), a natural polysaccharide. In this study, we used a computational technique to predict the amount of drug loading in MIL-100(Fe) and MIL-100(Fe)/CS with molecular dynamics software LAMMPS. Powder X-ray diffraction analysis was conducted to characterize the chitosan-coated MIL-100(Fe) loaded with cyclophosphamide (MIL-100(Fe)/CS/CP). The drug loading and release processes were quantified using UV spectroscopy at 193 nm. The toxic effect of MIL-100(Fe)/CS/CP was determined on human breast cancer (MCF-7) cells. In vivo images and H&E analysis show inhibition properties of MIL-100(Fe)/CS/CP on tumor cells. The conducted research indicates that computational calculation provides a unique insight into the drug adsorption since a proper understanding of the atomic interaction of MIL-100(Fe)/CS with anticancer drugs is important for developing experimental investigations. The biocompatibility and anticancer properties of chitosan molecules enhanced the tumor inhibitory effect of the particles compared with the MIL-100(Fe)/CP and free cyclophosphamide treatments.

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confidence: 82%

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confidence: 82%

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confidence: 90%

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confidence: 90%

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Chitosan-Coated MIL-100(Fe) as an Anticancer Drug Carrier: Theoretical and Experimental Investigation

Tohidi

Aghaie-Khafri

2023

ACS Med. Chem. Lett.

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“…K-562, an erythroleukemia line, was maintained in continous culture of minimum essential medium (MEM)-alpha and 10% fetal calf serum (Flow Laboratories, Mississauga, Ontario) [8]. A NK assay was performed by incubating 10 4 51chromium (Amersham, Montreal, Quebec)-labeled target cells (K-562) with varying numbers of PBM effector cells for 18 h at 37 °C, in a 5% CO 2 air atmosphere in MEM-alpha medium as described previously [10]. The assay was performed at effector-to-target cell ratios of 30:1, 10:l, 3:1, and 1:1.…”

Section: Methodsmentioning

confidence: 99%

Modulation of natural killer cell activity in stage I postmenopausal breast cancer patients on low-dose aminoglutethimide

Berry¹,

Green

Matheson

1987

Cancer Immunol Immunother

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Natural killer (NK) cells are important in surveillance against malignant cells. The activity of NK cells can be modulated by naturally occurring mediators; interferon, interleukin-2, and hormones. Low-dose aminoglutethimide (Ag 250 mg/day) inhibits the peripheral aromatization of androstenedione hence decreasing circulating estrogens. Of ten patients treated, seven were evaluable. There was a statistically significant increase in NK activity (P = 0.0025) following the administration of Ag. There was no consistent shift in NK cell number (Leu-11b positive cells). In vitro Ag did not alter NK activity whereas 17-beta-estradiol did. These data are consistent with an indirect effect of Ag on NK activity. Hence in vivo Ag which causes a reduction in serum estrogens in postmenopausal patients, also induces an increase in NK activity.

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Agents which Decrease Intracellular Thymidine Pools Cause an Augmentation in Human Natural Killer Activity in vitro

Matheson

Green

Hoar

et al. 1985

Genetic Consequences of Nucleotide Pool Imbalance

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Trimethoprim-induced augmentation of human natural killer activity in vitro

Cited by 7 publications

References 9 publications

Chitosan-Coated MIL-100(Fe) as an Anticancer Drug Carrier: Theoretical and Experimental Investigation

Chitosan-Coated MIL-100(Fe) as an Anticancer Drug Carrier: Theoretical and Experimental Investigation

Modulation of natural killer cell activity in stage I postmenopausal breast cancer patients on low-dose aminoglutethimide

Agents which Decrease Intracellular Thymidine Pools Cause an Augmentation in Human Natural Killer Activity in vitro

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