Triphenylpropylpiperazine Derivatives as New Potent Analgetic Substances

Synthesis, spectroscopic characterization, crystal structure and antifungal activity of thiourea derivatives containing a thiazole moiety

“…A colorless plate 0.15×0.08×0.005 mm 3 was mounted on a glass fiber in inert oil. Measurements were performed at 100 K on an Oxford Diffraction Xcalibur Nova diffractometer with mirror-focussed Cu-Kα radiation to 2 max 152° (99.3% complete to 145°).…”

“…The thiazole moiety belongs to an important class of N & S-containing heterocycles and when attached to a thiourea functional group forms the building block for pharmaceutical agents. They exhibit a wide spectrum of pharmaceutical activity, such as bactericidal, fungicidal [2], analgesic [3], anti-hypertensive [4], and anti-tumor [5]. Thiouracils are similarly used as anti-inflammatory and virucidal agents [6].…”

Green High-Yielding One-Pot Approach to Biginelli Reaction under Catalyst-Free and Solvent-Free Ball Milling Conditions

“…The 3,4-dihydropyrimidine and its derivatives are highly significant because they generally show diverse medicinal properties, such as calcium channel blockers, antihypertensive and anti-inflammatory agents, and α 1-a antagonists [8][9][10][11]. Furthermore, 3,4-dihydropyrimidine derivatives have emerged as important target molecules because of their pharmacological and therapeutic properties, such as antimitotic, antiviral, antitumor, anticarcinogenic, antibacterial, and fungicidal activities [12][13][14][15][16][17][18][19].…”

Synthesis, characterization, biological studies, and molecular modeling of mixed ligand bivalent metal complexes of Schiff bases based on $N$-aminopyrimidine-2-one/2-thione

“…Many pyrimidine derivatives are known to exhibit analgesic, 5 antihypertensive, 6 antitumor, 7 antimalarial, magnetic susceptibility, and electronic, infrared, and mass spectral analysis. All the complexes encouraged us to study their antimicrobial activities against gram-positive and gram-negative bacteria and fungi to give an insight into the steric and electronic effects on the biological activities of ligands with various substituents in the aromatic ring and their complexes.…”