Triple assessment of sentinel lymph node metastasis in early breast cancer using preoperative CTLG, intraoperative fluorescence navigation and OSNA

Mokhtar, Mohamed Mahmoud; Tadokoro, Yukiko; Nakagawa, Misako; Morimoto, Masami; Takechi, Hirokazu; Kondo, Kazuya; Tangoku, Akira

doi:10.1007/s12282-014-0551-1

Cited by 23 publications

(21 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The 12 eligible articles ( Choi et al , 2010 ; Khaddage et al , 2011 ; Snook et al , 2011 ; Le Frere-Belda et al , 2012 ; Vegue et al , 2012 ; Wang et al , 2012 ; Chen et al , 2013 ; Heilmann et al , 2013 ; Jimbo et al , 2013 ; Bettington et al , 2014 ; Pathmanathan et al , 2014 ; and Mokhtar et al , 2016 ) containing a total of 2833 patients with a mean sample size of 218 (range: 35–772) were included in this meta-analysis. All studies were designed by prospective methods.…”

Section: Resultsmentioning

confidence: 99%

One-step nucleic acid amplification assay is an accurate technique for sentinel lymph node biopsy of breast cancer patients: a meta-analysis

et al. 2017

View full text Add to dashboard Cite

Background:To estimate the accuracy of one-step nucleic acid amplification (OSNA) assay as an intra-operative sentinel lymph node biopsy (SLNB) for sentinel lymph node (SLN) metastasis in breast cancer.Methods:PubMed, Cochrane Library and Web of Science databases were searched by two independent reviewers to retrieve literature with per-patient analysis. The deadline was up until December 2016. A meta-analysis was performed using STATA, Meta-Disc, and Revman software. A random-effects model was used and subgroup analysis was carried out to identify possible sources of heterogeneity.Results:According to the inclusion criteria, 2833 patients from 12 studies were included in this meta-analysis. The pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR) and the area under the sROC curve (AUC) for detecting SLN metastasis were 0.87 (95% CI 0.81–0.91), 0.92 (95% CI 0.86–0.95), 10.65 (95% CI 6.18–18.34), 0.14 (95% CI 0.10–0.20), 75.08 (95% CI 37.77–149.22) and 0.94 (95% CI 0.91–0.95), respectively.Conclusions:The present study adds the evidence that OSNA assay is an accurate molecular diagnostic tool for intra-operatively detecting SLN metastasis in breast cancer. One-step nucleic acid amplification assay might be introduced into clinical usage for replacing traditional intro-operative diagnostic methods of SLNB.

show abstract

Section: Resultsmentioning

confidence: 99%

One-step nucleic acid amplification assay is an accurate technique for sentinel lymph node biopsy of breast cancer patients: a meta-analysis

et al. 2017

View full text Add to dashboard Cite

show abstract

“…These substitutes included the usage of indocyaninegreen fluorescent optical intraoperative SLNB, superparamagnetic iron oxide guided SLNB and CTLG . Meanwhile, CTLG is a well‐known localization method for SLN in breast cancer with very acceptable detection rates . The only drawback of this method is lacking accurate localization tool making it a very successful maneuver for mapping and an accepted part of dual localization with blue dye but not a single dependent method.…”

Section: Discussionmentioning

confidence: 99%

“…Another one studied the possibility of combination of CTLG with fluorescence imaging as localization methods with promising results . A question is raised about the possibility of accurate localization of the SLN detected by CTLG which offers a detection rate up to 100% …”

Section: Introductionmentioning

confidence: 99%

Preoperative localization of sentinel lymph node in breast cancer patients by silver wire insertion or liquid charcoal injection guided by CT lymphography

et al. 2019

View full text Add to dashboard Cite

Dual localization of SLN in breast cancer patients using isotope & dye is the best‐approved modality with limitations such as high cost of radioactive materials, complex logistic preparations & scheduling issues, especially in developing countries. We investigated the feasibility & accuracy of a novel technique for SLN localization using silver wire insertion or liquid charcoal injection guided by CT lymphography. 120 patients with clinically node‐negative breast cancer were enrolled. In the test group, SLN was localized using preoperative CTLG guided injection of liquid charcoal or by placing a 3 cm silver wire. In addition, intraoperative SLN mapping was performed using methylene blue dye followed by searching for the SLN localized by both methods. In the control group, SLN was localized by the blue dye only. Feasibility, accuracy, detection rates, and number of SLNs retrieved were reported as well as matching between the LN detected with the CTLG and that detected with the dye technique. SLN could be detected in 59 out of 60 patients (98.3%) in the test group and in 54 out of 60 patients (90%) in the control group (P = .057). In self‐controlled analysis of the test group comparing CTLG only to dye only was significant (P = .050). Comparing charcoal to silver wire in detection was statistically insignificant (P = .5). This novel method can offer advantages which are as follows: being more accurate than the dye alone, saving operative time, abandoning complex logistic preparations for the radioisotope, and solving the problem of timing.

show abstract

“…Furthermore, SLN detection is difficult when the SLN is close to the site of RI injection, due to shine-through artifacts [2]. Another method for visualizing SLNs and lymphatics is computed tomography lymphography (CTL), which does not require special equipment and has recently been applied in melanoma, breast, esophageal, and gastric cancer [15–21]. However, there are few reports of CTL for SLN mapping in patients with N0 early oral cancer [2, 22, 23].…”

Section: Introductionmentioning

confidence: 99%

CT lymphography for sentinel lymph node mapping of clinically N0 early oral cancer

et al. 2019

View full text Add to dashboard Cite

BackgroundThe objectives of this retrospective study were to evaluate the usefulness of computed tomography lymphography (CTL) and to clarify the optimal timing of CTL in sentinel lymph node (SLN) mapping of clinically N0 early oral cancer.MethodsTwenty patients with clinically N0 early oral cancer underwent CTL with a 128 multi-detector row CT scanner to detect SLN the day before resection of primary tumor and SLN biopsy with indocyanine green (ICG) fluorescence guidance. CT scanning was performed in the first 10 patients at 2, 5, and 10 min after submucosal injection of iopamidol and in the remaining 10 patients at 2, 3.5, 5, and 10 min after the injection of contrast medium. We evaluated the SLN detection rate at each scan timing and the number and location of SLNs. We evaluated whether CTL-enhanced SLNs could be identified intraoperatively as ICG fluorescent lymph nodes.ResultsSLNs were detected by CTL in 19 of the 20 patients (95.0%), and the mean number of SLNs was 2 (range, 1–4). All SLNs were located on the ipsilateral side; 35 of 37 SLNs were located at level I and II, and 2 SLNs were lingual lymph nodes. All SLNs could be detected 2 min and 3.5–5 min after contrast medium injection, and CTL-enhanced SLNs could be identified intraoperatively as fluorescent lymph nodes.ConclusionsCTL could facilitate the detection of SLNs in early oral cancer, and the optimal timing of CT scanning was at 2 and 5 min after injection of contrast medium.

show abstract

Triple assessment of sentinel lymph node metastasis in early breast cancer using preoperative CTLG, intraoperative fluorescence navigation and OSNA

Cited by 23 publications

References 29 publications

One-step nucleic acid amplification assay is an accurate technique for sentinel lymph node biopsy of breast cancer patients: a meta-analysis

One-step nucleic acid amplification assay is an accurate technique for sentinel lymph node biopsy of breast cancer patients: a meta-analysis

Preoperative localization of sentinel lymph node in breast cancer patients by silver wire insertion or liquid charcoal injection guided by CT lymphography

CT lymphography for sentinel lymph node mapping of clinically N0 early oral cancer

Contact Info

Product

Resources

About