Triple dissociation of attention networks in stroke according to lesion location

Rinne, Paul; Hassan, Mursyida; Goniotaki, Despoina; Chohan, K.; Sharma, Pankaj; Langdon, Dawn; Soto, David; Bentley, Paul

doi:10.1212/wnl.0b013e3182a2ca34

Cited by 51 publications

(49 citation statements)

References 41 publications

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“…Several fMRI studies have shown that orienting tasks activate areas of the superior temporal lobe and the temporal–parietal junction . Evidence from lesion studies has revealed that impairments in orienting accompany lesions of the right pulvinar and temporoparietal cortex and the superior temporal lobe . In the present study, we found no differences in the orienting network between the CT group, the non‐CT group, and the healthy controls.…”

Section: Discussioncontrasting

confidence: 63%

Selective impairment of attention networks in breast cancer patients receiving chemotherapy treatment

Chen

Ren

et al. 2014

Psycho-Oncology

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Section: Discussioncontrasting

confidence: 63%

Selective impairment of attention networks in breast cancer patients receiving chemotherapy treatment

Chen

Ren

et al. 2014

Psycho-Oncology

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“…This effect is in keeping with studies on cueing effects [38] that show that incongruent spatial information carried by a cue and a target could lead to a slower response to the target, thus enhancing the interaction of the processing of the cue and target in the brain, especially under short stimulus onset asynchronies. The interdependence between components is also supported at the neural level: Rinne and colleagues [78] reported anatomical dependency of internetwork interactions and, to a lesser extent, overlap in a cohort of stroke patients, showing how lesions to right frontoparietal regions could modulate the interactions among the three attentional components.…”

Section: Discussionmentioning

confidence: 94%

Parsing the intrinsic networks underlying attention: A resting state study

Visintin

Panfilis

Antonucci

et al. 2015

Behavioural Brain Research

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The attention system functionally modulates brain activity to exert control over thoughts, feelings and actions. Three distinct but mutually interacting components of attention have been hypothesized: alerting, which mediates the maintenance of a state of vigilance toward an upcoming stimulus; orienting, which supports the selection of sensory information, and executive control that is involved in detecting and resolving cognitive conflicts. The performance of tasks probing these components engages fronto-parietal and thalamic regions. Also, general attention has been associated with the activity of resting-state networks (RSNs), which are sets of brain regions with synchronous temporal fluctuations. Importantly, the association between the intrinsic brain activity of RSNs and the efficiency and integration of the specific attentional components remains largely unexplored. For this aim, we recruited twenty healthy volunteers who performed the Attention Network Test-Revised (ANT-R), assessing the alerting, orienting and executive control components as well as their interactions, and underwent resting-state functional magnetic resonance imaging. For each participant RSNs were estimated using double regression. The RSNs spanning across areas previously implicated in attentional processing were correlated with ANT-R scores using multiple regressions. Significant brain behavior correlations emerged between ANT-R scores and RSNs comprising the regions relevant for attentional processing, i.e., left and right prefronto-parietal (PFC-PC), dorsal attentional (DAN), salience (SN), and default mode (DMN) networks. The activity of PFC-PC networks was correlated with alerting in parietal and frontal regions, and with location conflict in the frontal regions. The DAN connectivity was correlated with flanker, location conflict, and their interaction in parietal regions. SN was associated with flanker by location and flanker by orienting interactions in the inferior frontal regions. Finally, the activity of the DMN was associated with flanker conflict in midline structures such as precuneus and anterior cingulate cortex and also in right angular gyrus. These results suggest that the brain is endowed with an intrinsic functional organization to support attention, not only in its global function, but also in its distinct components.

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“…Differential effects of lesions upon the different attention networks have been confirmed in neurological patients (Hu et al, 2013;Rinne et al, 2013;Xu et al, 2010). Attention deficits are among the most commonly observed cognitive impairments after stroke Robertson and Murre, 1999) and are known to severely affect rehabilitation (McDowd et al, 2003) resulting in a poorer outcome (Murphy and Corbett, 2009).…”

Section: Clinical Relevance Of Attention Deficits and Tdcs As A Neuromentioning

confidence: 94%

Modulation of attention functions by anodal tDCS on right PPC

Roy

Sparing²,

Fink

et al. 2015

Neuropsychologia

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Triple dissociation of attention networks in stroke according to lesion location

Abstract: More than half of all stroke patients can be expected to have a lesion location classifiable into 1 of the 3 principal attention networks. Our results have potential implications for therapy personalization in focal brain diseases including stroke.

Cited by 51 publications

References 41 publications

Selective impairment of attention networks in breast cancer patients receiving chemotherapy treatment

Selective impairment of attention networks in breast cancer patients receiving chemotherapy treatment

Parsing the intrinsic networks underlying attention: A resting state study

Modulation of attention functions by anodal tDCS on right PPC

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