2009
DOI: 10.1021/np900237a
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Triterpenoid Saponins from Rubus ellipticus var. obcordatus

Abstract: Ten new triterpenoid saponins (1-10), named rubusides A-J, and 21 known saponins (11-31) were isolated from the roots of Rubus ellipticus var. obcordatus. The structures of 1-10 were established on the basis of spectroscopic analyses, mainly NMR and MS, and chemical degradations. The compounds demonstrated inhibitory activities against alpha-glucosidase with IC50 values in the range 0.65-3.09 mM.

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Cited by 69 publications
(39 citation statements)
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“…We evaluated the isolated compounds for their inhibitory activity against α -glucosidase since some compounds are known α -glucosidase inhibitors [15]. The results are shown in Table 3, with acarbose used as a positive control.…”
Section: Resultsmentioning
confidence: 99%
“…We evaluated the isolated compounds for their inhibitory activity against α -glucosidase since some compounds are known α -glucosidase inhibitors [15]. The results are shown in Table 3, with acarbose used as a positive control.…”
Section: Resultsmentioning
confidence: 99%
“…A C C E P T E D ACCEPTED MANUSCRIPT 11 were mainly isolated from Rosaceous plants [35][36][37]. From this type of compounds, In another approach, we focused on the activity of compounds that were chemically altered in C-28 side chain with ester group of ring A modified structures.…”
Section: Structure−activity Relationship Studiesmentioning
confidence: 99%
“…Furthermore, the absolute configuration of these sugars was determinate by GC analysis, according to a method previously reported with some modification. 6 Briefly, solution of were also observed. Thus, the glucose unit should be located at C-29 through an ether linkage to C-1′.…”
Section: Methodsmentioning
confidence: 99%