Tritium labelled compounds of high specific activity II. amitriptyline

Abstract

SumARYTritium labelled amitriptyline ( I ) of high specific activity was prepared. The tritium was incorporated by catalysed isotope exchange into the precursor dibenzosuberone, which had been previously converted into a cyclic ketal, in order to protect the 0x0-group against reduction. It was demonstrated by degradation that isotope exchange occurred exclusively in specified position.

(2,2‐Diphenyl‐[1,3]oxathiolan‐5‐ylmethyl)‐(3‐phenyl‐propyl)‐amine: a Potent and Selective 5‐HT1A Receptor Agonist

“…EtOAc, 100 %) to give the A C H T U N G T R E N N U N G desired amine (21-36) as oil. Known compounds, 4-chloromethyl-2,2-diphenyl- [1,3]dioxolane, [13] 2-benzhydryl-4-chloromethyl- [1,3]dioxolane, [13] 4-(chloromethyl)spiro[1,3-dioxolane-2,9'-[9H]fluorene], [20] 4'-(chloromethyl)-10,11-dihydro-spiro[5H-dibenzoA C H T U N G T R E N N U N G [a,d]cyclohepten-5,2'-[1,3]dioxolane], [21] 5-(chloromethyl)-2,2-diphenyl-1,3-oxathiolane, [20] 4-(chloromethyl)-2,2-diphenyl-1,3-dithiolane, [20] were prepared using the procedure described above.…”