Tropical Skin Diseases in Children: A Review—Part II

García‐Romero, María Teresa; Lara‐Corrales, Irene; Kovarik, Carrie L.; Pope, Elena; Arenas, Roberto

doi:10.1111/pde.12778

Cited by 7 publications

(6 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…India has varied geographical area so skin disease prevalence vary from 7.9 to 60%. [16][17][18][19] In this study, the relation of age, religion, education and member of household with history of skin disease were highly statistically significant and their p-values were 0.002, 0.000, 0.000 and 0.000, respectively. High prevalence of infectious skin disease among school children who had lived with > 3 (12.1%) crowding index was shown significant by Iraq, Khalifa KA et al [20] According to Saudi Arabia, Amin TT et.al, [21] who had large family size that family had a predictor risk factor for some transmissible "skin infections" (pediculosis and tinea).…”

Section: Discussionmentioning

confidence: 79%

An Assessment of Skin Diseases in People and Their Quality of Life in Bundelkhand Region of Uttar Pradesh

Kumar

Singh

Barman

et al. 2023

Indian J Community Health

View full text Add to dashboard Cite

Background: Skin diseases occur in all age groups in developed and developing countries. Various types of skin diseases are found worldwide and depend on factors like environment, surrounding ecology, dietary habits, socioeconomic status, mental health, and literacy. Health-related quality of life (HRQOL) improves after treatment or cure of the diseases. Objectives: To estimate the pattern of skin disease. To find out the quality of life and association of skin disease with sociodemographic factors among patients. Methods: This observational cross-sectional study was done in skin OPD at the tertiary care center, Banda district of Uttar Pradesh, India from May 2022 to July 2022. All patients who attended to skin OPD during study period were included in the study after taking informed verbal consent. Results: Skin diseases had further divided in subcategories which were infectious conditions, pigmentary disorders, inflammatory dermatoses, miscellaneous skin conditions, benign tumor and other lesions with their percentage 44.8, 10.5, 28.6, 7.1, 2.9 and 6.2%, respectively in this study Classes of DQLI where major portion of patients (49.52%) were in ‘Small effect on patient’s life’ category. The relation of age, religion, education and member of household with history of skin disease were found to be highly statistically significant. Conclusion: Infectious skin diseases were found more common in study area. Male populations were more commonly affected. Skin diseases were more common in age group of 18–60 years. Study participants showed no predominant effect on quality of life. But small effect class had major effect on participant’s quality of life.

show abstract

Section: Discussionmentioning

confidence: 79%

An Assessment of Skin Diseases in People and Their Quality of Life in Bundelkhand Region of Uttar Pradesh

Kumar

Singh

Barman

et al. 2023

Indian J Community Health

View full text Add to dashboard Cite

show abstract

“…Extensive literature searches on Neglected Tropical Diseases (NTDs) showed that leishmaniasis, onchocerciasis, schistosomiasis, and trypanosomiasis have started exhibiting multidrug resistance, mediated by P-glycoprotein efflux pumps [11,12,25,34]. New drugs targeting NTD's are undergoing clinical trials [35][36][37], and efforts are being taken to uncover the mechanisms of drug resistance employed by the causative helminths.…”

Section: Resultsmentioning

confidence: 99%

Computational Studies of Drug Repurposing Targeting P-Glycoprotein-Mediated Multidrug-Resistance Phenotypes in Agents of Neglected Tropical Diseases

Jaishankar¹,

Muthamilselvan

Palaniappan

2020

E. Coli Infections - Importance of Early Diagnosis and Efficient Treatment

View full text Add to dashboard Cite

Mammalian ABCB1 P-glycoprotein is an ATP-dependent efflux pump with broad substrate specificity associated with cellular drug resistance. Homologous to this role in mammalian biology, the P-glycoprotein of agents of neglected tropical diseases (NTDs) mediates the emergence of multidrug-resistance phenotypes. The clinical and socioeconomic implications of NTDs are exacerbated by the lack of research interest among Big Pharma for treating such conditions. This work aims to characterise P-gp homologues in certain agents of key NTDs, namely (1) Protozoa: Leishmania major, Trypanosoma cruzi; (2) Helminths: Onchocerca volvulus, Schistosoma mansoni. Based on structural modelling of the organismal P-gp homologues, potential antibiotics targeting these structures were identified based on similarity and repurposing of existing drugs. Docking studies of the Pgp receptor-antibiotic ligand complexes were carried out and the most tenable target-ligand conformations assessed. The interacting residues were identified, and binding pockets studied. The in silico studies yielded measurements of the relative efficacy of the new drugs, which need experimental validation. Our studies could lay the foundation for the development of effective synergistic or new therapies against key neglected tropical diseases. The potential mechanisms of multidrug resistance emergence in E. coli were examined.

show abstract

“…47). Chyluria also may be noted in long-standing cases (Lupi et al 2015 -Romero et al 2016). • Clinical feature: Onchocercoma is the most distinct cutaneous manifestation and presents as firm, painless, freely mobile subcutaneous nodule of 1-3 cm in size, located over a bony prominence.…”

Section: 5mentioning

confidence: 97%

Tropical Diseases of the Skin

Tiwary¹,

Kumar²,

S³

et al. 2020

Atlas of Dermatology, Dermatopathology and Venereology

View full text Add to dashboard Cite

Infectious dermatoses are the major burden of skin diseases prevalent in tropics. Some fungal, protozoal, and helminthic infestations are exclusively seen in tropical regions. Endemic pemphigus and few nutritional deficiencies account for majority of noninfectious tropical dermatoses. Basically, the climatic conditions and inhabiting human's culture and behavior are the chief attributable factors in acquiring and perpetuation of these diseases. Besides, migration and/or tourism further augment the risk of dissemination of tropical skin diseases to other regions of the world.

show abstract

Tropical Skin Diseases in Children: A Review—Part II

Cited by 7 publications

References 34 publications

An Assessment of Skin Diseases in People and Their Quality of Life in Bundelkhand Region of Uttar Pradesh

An Assessment of Skin Diseases in People and Their Quality of Life in Bundelkhand Region of Uttar Pradesh

Computational Studies of Drug Repurposing Targeting P-Glycoprotein-Mediated Multidrug-Resistance Phenotypes in Agents of Neglected Tropical Diseases

Tropical Diseases of the Skin

Contact Info

Product

Resources

About