Troponin levels in patients with stable CAD

Daněk, Josef; Hnátek, Tomáš; Malý, Martin; Táborský, Miloš; Běláček, Jaromír; Škvařil, Jan; Pospíšilová, Lenka; Černohous, Miroslav; Sedloň, Pavel; Hajšl, Martin; Zavoral, Miroslav

doi:10.1016/j.crvasa.2016.12.001

Cited by 11 publications

(15 citation statements)

References 18 publications

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“…27,28 ). Pre-procedural troponin levels likely mirror the extent of coronary involvement as suggested by studies searching for any association between baseline troponin levels and the SYNTAX score 29,30 . However, no statistically significant association between post-procedural troponin elevation and the SYNTAX score was found in our study.…”

Section: Discussionmentioning

confidence: 98%

Selective coronary angiography, percutaneous coronary intervention and asymptomatic peri-procedural myocardial injury

Gřiva¹,

Šťastný²,

Kopriva³

et al. 2019

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Background. While there have been a number of studies reporting the incidence and implications of elevated troponin levels after percutaneous coronary intervention (PCI), the body of information about the incidence, associations, and implications of elevated troponin levels following coronary angiography (CAG) is limited. Materials and Methods. A total of 220 consecutive patients with stable coronary artery disease or intermediate or low-risk acute coronary syndrome without persistent ST-segment elevation (NSTE-ACS) were included in our study. High-sensitivity cardiac troponin I (hs-cTnI) levels were measured before and after coronary angiography (CAG) in patients with or without PCI and correlated with a number of clinical variables. Results. Hs-cTnI elevations above the 99 th percentile upper reference limit (URL), or above 20% of the initially positive, yet already declining values, were found in 60 (37.2%) patients after CAG and in 45 (76.2%) patients undergoing PCI. Significant correlations of hs-cTnI elevation were found with the following variables: volume of contrast, fluoroscopy time, dose-area product, amount of contrast agent injected directly into the coronary arteries, total time of balloon dilation and the number and total length of implanted stents (P<0.001 for all). Conclusion. While an asymptomatic elevation of hs-cTnI is a common finding after PCI, it does occur, quite surprisingly, also after CAG. Despite contradictory views regarding the clinical relevance of asymptomatic post-procedural elevated hs-cTnI levels, it is generally believed that a mild elevation is not associated with an increased risk. Still, it may pose a diagnostic quandary following a successful interventional procedure and even more so after an uncomplicated CAG. Trial Registration: Clinicaltrials.gov -NCT02960321

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Section: Discussionmentioning

confidence: 98%

Selective coronary angiography, percutaneous coronary intervention and asymptomatic peri-procedural myocardial injury

Gřiva¹,

Šťastný²,

Kopriva³

et al. 2019

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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“…serum assay was introduced [11]. There are three types of cTn (C, I, and T), and each type plays different roles in a contractile regulatory complex as follows [12,13]: (1) cTn T binds to the actin filament, (2) cTn C acts as calcium ion binding site, and (3) cTn I inhibits interaction of actin with the myosin heads when the intracellular calcium concentration is insufficient to initiate muscle contraction. CTn exists also in skeletal muscle fibers, but a difference in version of cTn provides a tissue specificity for cardiac muscle [14].…”

Section: Characteristics Of Ctnmentioning

confidence: 99%

“…CTn exists also in skeletal muscle fibers, but a difference in version of cTn provides a tissue specificity for cardiac muscle [14]. Over the other cardiac markers, cTn has advantages with improved performance and superior sensitivity [12,13]. The both types of cTn I and T can be used for detecting myocardial damage, and the accuracies were similar in a direct comparison between the recently available assays [15].…”

Section: Characteristics Of Ctnmentioning

confidence: 99%

“…cTn is a component of the myofibrillar apparatus that was discovered in the 1960s, but it was not until the 1990s that a reliable serum assay was introduced [ 11 ]. There are three types of cTn (C, I, and T), each of which plays a different role in the contractile regulatory complex [ 12 , 13 ]. Specifically, cTn T binds to the actin filament, cTn C acts as a calcium ion binding site, and cTn I inhibits the interaction between actin and the myosin heads when the intracellular calcium concentration is insufficient to initiate muscle contraction.…”

Section: Characteristics Of Ctnmentioning

confidence: 99%

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Myocardial injury in noncardiac surgery

Park

Lee

2022

Korean J Anesthesiol

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“…The risk of myocardial ischemia or infarction is higher in patients with ESRD compared to the general population (4). Cardiac troponins (cTn) can be used to diagnose CAD (5). However, the troponin level is thought to be increased in ESRD patients without coronary events (6).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Correlation Between Cardiac Troponin I Versus Causes of Admission and In-Hospital Mortality in End-Stage Renal Disease Patients

2021

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Objectives: There are arguments regarding the relationship between the level of cardiac troponin I (cTnI) and presence of cardiac diseases in end-stage renal disease (ESRD) patients. This study aimed to determine the relationship between positivity of cTnI and cause of admission and patients’ outcome in ESRD patients. Methods: In this cross-sectional study, all ESRD patients who had checked cTnI and admitted to two university hospitals in Isfahan, Iran were enrolled. The patients’ demographic characteristics, cause of admission, and outcome were correlated with cTnI positivity. Results: Out of a total of 348 ESRD patients, 100 subjects had positive cTnI. There was a positive correlation between age and admission in Al-Zahra hospital with positive cTnI. In contrast, vascular access complication and hypertension had a negative correlation with positivity of cTnI. The results of multiple logistic regression analysis showed that factors including age (OR: 1.04; 95% CI: 1.01 - 1.07; P: 0.004) and infections (OR: 3.1; 95% CI: 1.3 - 7.3; P: 0.009) were associated with increased risk of in-hospital mortality. In contrary, exit site infection (OR: 0.11; 95% CI: 0.01 - 0.8; P: 0.03) and hypertension (OR = 0.32; 95% CI: 0.14 - 0.77; P = 0.01) were associated with decreased risk of mortality. Although cTnI positivity correlated with patients’ in-hospital mortality (OR = 2.038). Conclusions: Although positive cTnI had a borderline association with in-hospital mortality in ESRD patients, further multicenter studies with larger sample size are required to confirm the results.

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Troponin levels in patients with stable CAD

Cited by 11 publications

References 18 publications

Selective coronary angiography, percutaneous coronary intervention and asymptomatic peri-procedural myocardial injury

Selective coronary angiography, percutaneous coronary intervention and asymptomatic peri-procedural myocardial injury

Myocardial injury in noncardiac surgery

Evaluation of the Correlation Between Cardiac Troponin I Versus Causes of Admission and In-Hospital Mortality in End-Stage Renal Disease Patients

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