True incidence of uterine adenomatoid tumors

Abstract

Uterine adenomatoid tumors (UATs) are benign tumors of the uterine serosa and myometrium that originate from the mesothelium and forming gland-like structures. This study was conducted in order to determine the true incidence of UATs, which are usually an incidental finding during uterine surgery performed for other causes. UATs may resemble pre-existing vessels and lymphatic ducts, as well as metastatic adenocarcinomas. A total of 199 consecutive surgical operations (134 hysterectomies and 65 uterus-preserving tumor excisions) were performed by a single team of gynecologists and examined by a single attending pathologist, who performed a thorough macro- and microscopic examination of all the specimens. UATs were identified in nine (5%) out of the 199 cases [six (5%) out of the 134 hysterectomies and three (5%) out of the 65 uterus-preserving tumor excisions]. Therefore, the true incidence of UATs may be significantly higher than 1%, which is the incidence reported in the presently available literature.

Leiomyoadenomatoid Tumor of the Uterus: Case Report

“…AT'lerin insidansının birçok yayında %1'ler civarında olduğu bildirmiş olmasına rağmen, gerçek insidansın belirlenmesi için yapılan son yayında immünohistokimyasal boyamanın kullanımı ile AT insidansının %5'ler civarında olduğu gösterilmiştir. [4][5][6] AT'ler, genellikle 4 cm'yi geçme-yen tek bir lezyon olarak uterin korpusta subserozal ve intramural yerleşimli olup, nadiren de kornual bölgelerde saptanabilmektedirler. AT'ler klinik olarak leiomiyomla ve ovaryan kitle ile karışabilmek-tedir.…”

“…insidansının %1 olduğunu bildiren yayınlar mevcut olmakla birlikte, son yıllarda yapılan bir çalışmada, bilinenin aksine immünohistokimyasal çalışma ile uterusun adenomatoid tümör insidansının %5 olduğunu ortaya koymuştur. [4][5][6] AT, benign olmalarına rağmen görünümleri overyan seks kord tümörünü andıran uterin tümör, adenomiyom, malign mezotelyoma, hemanjiyom ve lenfanjiyom ile ayırıcı tanısı yapılması gereken tümörlerdir. 7 Uterusun adenomatoid tümörleri genellikle düz kas hipertrofisi ile birliktedir.…”

Adenomatoid tumour of the uterus is frequently associated with iatrogenic immunosuppression

“…It most commonly arises in the female or male genital tract, and the uterus is the most frequently affected organ . The incidence of uterine AT is 0.1–5%, and it is not an extremely rare lesion for surgical pathologists. A recent study by Wang et al .…”

“…It most commonly arises in the female or male genital tract, and the uterus is the most frequently affected organ. 11 The incidence of uterine AT is 0.1-5%, 8,12 and it is not an extremely rare lesion for surgical pathologists. A recent study by Wang et al 13 is among a few molecular studies that demonstrated the clonality of the cells lining the lymphatic vessel-like lumen of AT using human androgen receptor gene (HUMARA) assays.…”

Adenomatoid tumor of the uterus; report of a rare incidentaloma

“…They are relatively unusual neoplasms in the uterus where they are often detected incidentally in hysterectomy specimens removed for an unrelated cause. 2,3 These are often grossly mistaken for leiomyomas which are frequent in occurrence. 4 In some instances, these can have bizarre histomorphological appearances and hence need to be distinguished from malignant tumors.…”