Trypanosoma cruzi infection in naturally infected dogs from an endemic region of Cundinamarca, Colombia

Mesa-Arciniegas, Paola; Parra-Henao, Gabriel; Carrión-Bonifacio, Ángela; Casas-Cruz, Adriana; Patiño-Cuellar, Ana; Díaz-Rodríguez, Katherine; Garzón-Jiménez, Sandra; Almansa-Manrique, Jorge; Bernal-Rosas, Yuly; Hernández-Lamus, Claribell; Pedraza‐Toscano, Adriana; Torres, Orlando

doi:10.1016/j.vprsr.2018.11.006

Cited by 8 publications

(9 citation statements)

References 23 publications

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“…Here we reported a moderate seroprevalence (34%) in dogs from the department of Antioquia, where P. geniculatus is the only reported species ( Guhl et al, 2007 ). However, the seroprevalence reported here is higher than the prevalence of infection reported in other departments, such as Cundinamarca (29.49%), and Meta (25.6%), where the presence of P. geniculatus is widely known ( Mesa-Arciniegas et al, 2020 ; Turriago et al, 2008 ). The higher seroprevalence in this area could be a result of both vector and oral transmission by the ingestion of or contact with infected sylvatic mammals such as D. marsupialis .…”

Section: Discussioncontrasting

confidence: 67%

Trypanosoma cruzi infection in domestic and synanthropic mammals such as potential risk of sylvatic transmission in a rural area from north of Antioquia, Colombia

Cantillo-Barraza

Bedoya

Xavier

et al. 2020

Parasite Epidemiology and Control

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In Colombia, dogs and opossum are the most important mammals in domestic and sylvatic T. cruzi transmission. However, the role of both species has not been evaluated in areas where both species converge in the peridomestic area. To evaluate the infection status of domestic and wild mammals in peridomestic habitats of Puerto Valdivia, Antioquia Department. The infection of domestic dogs and small wild mammals was performed by hemoculture, molecular and serological methods. Additionally, the infection in children under 15 years old and triatomine searches was carried out. We found that 16.07% and 34% dogs, and 59.1% and 61.1% Didelphis marsupialis were found positive by molecular and serological methods respectively. Moreover, in 25% and 75% of the infected dogs were detected TcI Dom and TcI sylvatic, respectively, while all the D. marsupialis were infected with TcI. Six Rattus rattus and three Proechimys semispinosus were captured but without T. cruzi infection. Finally, none of the 82 children were positive and no triatomine bugs were captured. D. marsupialis and domestics dogs have an important role in the transmission of T. cruzi suggesting a potential risk in T. cruzi transitions areas.

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Section: Discussioncontrasting

confidence: 67%

Trypanosoma cruzi infection in domestic and synanthropic mammals such as potential risk of sylvatic transmission in a rural area from north of Antioquia, Colombia

Cantillo-Barraza

Bedoya

Xavier

et al. 2020

Parasite Epidemiology and Control

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“…Currently 6 to 8 million people are infected and more than 100 million are at risk [12]. Chagas’ disease (CD) presents two clinical stages, an acute phase where symptoms are more asymptomatic, and a chronic phase which leads to heart failure or even death [13]. Currently, two drugs are used against the disease; benznidazole and nifurtimox [14].…”

Section: Introductionmentioning

confidence: 99%

Trypanocidal Mechanism of Action and in silico Studies of p-Coumaric Acid Derivatives

Lopes

Castillo

Monteiro

et al. 2019

IJMS

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Trypanosoma species are responsible for chronic and systemic infections in millions of people around the world, compromising life quality, and family and government budgets. This group of diseases is classified as neglected and causes thousands of deaths each year. In the present study, the trypanocidal effect of a set of 12 ester derivatives of the p-coumaric acid was tested. Of the test derivatives, pentyl p-coumarate (7) (5.16 ± 1.28 μM; 61.63 ± 28.59 μM) presented the best respective trypanocidal activities against both epimastigote and trypomastigote forms. Flow cytometry analysis revealed an increase in the percentage of 7-AAD labeled cells, an increase in reactive oxygen species, and a loss of mitochondrial membrane potential; indicating cell death by necrosis. This mechanism was confirmed by scanning electron microscopy, noting the loss of cellular integrity. Molecular docking data indicated that of the chemical compounds tested, compound 7 potentially acts through two mechanisms of action, whether by links with aldo-keto reductases (AKR) or by comprising cruzain (CZ) which is one of the key Trypanosoma cruzi development enzymes. The results indicate that for both enzymes, van der Waals interactions between ligand and receptors favor binding and hydrophobic interactions with the phenolic and aliphatic parts of the ligand. The study demonstrates that p-coumarate derivatives are promising molecules for developing new prototypes with antiprotozoal activity.

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“…Such high rate of prevalence of T. cruzi-specific antibodies in dogs was reported in Argentina in 1985 and 1989 [33,34], before the South Cone Initiative to control/eradicate Chagas disease (INCO-SUR-Chagas) was implemented in 1991 [35]. The prevalence of T. cruzi reactive antibodies in dogs is reported at 10%-30% in the Americas, including Mexico, Argentina, Chile, the Amazon basin, USA and Colombia, [9,15,36,37]. The prevalence of T. cruzi sero-reactivity in the province of Guayas, Ecuador was reported at 11.3% in the year 2012 [38].…”

Section: Discussionmentioning

confidence: 99%

Trypanosoma cruzi co-infections with other vector borne diseases are frequent in dogs from the pacific coast of Ecuador

Rivadeneira-Barreiro

Jiménez

Vázquez-Chagoyán

et al. 2021

Microbial Pathogenesis

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Trypanosoma cruzi infection in naturally infected dogs from an endemic region of Cundinamarca, Colombia

Cited by 8 publications

References 23 publications

Trypanosoma cruzi infection in domestic and synanthropic mammals such as potential risk of sylvatic transmission in a rural area from north of Antioquia, Colombia

Trypanosoma cruzi infection in domestic and synanthropic mammals such as potential risk of sylvatic transmission in a rural area from north of Antioquia, Colombia

Trypanocidal Mechanism of Action and in silico Studies of p-Coumaric Acid Derivatives

Trypanosoma cruzi co-infections with other vector borne diseases are frequent in dogs from the pacific coast of Ecuador

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