Tryptophan depletion reduces right inferior prefrontal activation during response inhibition in fast, event-related fMRI

Rubia, Katya; Lee, Francis; Cleare, Anthony J.; Tunstall, Nigel; Fu, Cynthia H.Y.; Brammer, Michael; McGuire, Philip

doi:10.1007/s00213-004-2116-z

Cited by 159 publications

(173 citation statements)

References 111 publications

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“…'*'0.10o po0.05; *po 0.05; **po 0.01; ***po0.001. (Rubia et al, 2005). These findings bear a resemblance to the current observations of and reduced activation of the dorsolateral prefrontal cortex, increased activation of the middle occipital gyrus during associative learning.…”

Section: Discussionsupporting

confidence: 70%

“…Similar BOLD-effects have been observed in human ecstasy users, that is, an increased visual cortex activation after photic stimulation where the magnitude of the increase was positively related to the degree of prior ecstasy exposure (Cowan et al, 2006). In addition, there is evidence of serotonergic modulation of functional brain activity in the prefrontal cortex and limbic structures during a cognitive challenge (Evers et al, 2005;Rubia et al, 2005). In one study, acute tryptophan depletion Ecstasy and human cognitive brain function G Jager et al significantly reduced brain activation in the right orbitoinferior prefrontal cortex, whereas it increased activation in the superior and medial temporal cortex.…”

Section: Discussionsupporting

confidence: 49%

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Assessment of Cognitive Brain Function in Ecstasy Users and Contributions of Other Drugs of Abuse: Results from an fMRI Study

Jager

Win

Tweel

et al. 2007

Neuropsychopharmacol

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Heavy ecstasy use has been associated with neurocognitive deficits in various behavioral and brain imaging studies. However, this association is not conclusive owing to the unavoidable confounding factor of polysubstance use. The present study, as part of the Netherlands XTC Toxicity study, investigated specific effects of ecstasy on working memory, attention, and associative memory, using functional magnetic resonance imaging (fMRI). A large sample (n ¼ 71) was carefully composed based on variation in the amount and type of drugs that were used. The sample included 33 heavy ecstasy users (mean 322 pills lifetime). Neurocognitive brain function in three domains: working memory, attention, and associative memory, was assessed with performance measures and fMRI. Independent effects of the use of ecstasy, amphetamine, cocaine, cannabis, alcohol, tobacco, and of gender and IQ were assessed and separated by means of multiple regression analyses. Use of ecstasy had no effect on working memory and attention, but drug use was associated with reduced associative memory performance. Multiple regression analysis showed that associative memory performance was affected by amphetamine much more than by ecstasy. Both drugs affected associative memory-related brain activity, but the effects were consistently in opposite directions, suggesting that different mechanisms are at play. This could be related to the different neurotransmitter systems these drugs predominantly act upon, that is, serotonin (ecstasy) vs dopamine (amphetamine) systems.

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Section: Discussionsupporting

confidence: 70%

Section: Discussionsupporting

confidence: 49%

Assessment of Cognitive Brain Function in Ecstasy Users and Contributions of Other Drugs of Abuse: Results from an fMRI Study

Jager

Win

Tweel

et al. 2007

Neuropsychopharmacol

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“…For example, Rubia et al (2005a) found that ATD decreased right orbito-inferior prefrontal activation in fMRI during the no-go condition, although there was no significant alteration in inhibitory performance on task. Citalopram enhanced the response of the lateral orbitofrontal cortex (BA47) to the no-go condition, whereas it attenuated the response to the no-go condition in the medial orbitofrontal (BA11), using fMRI (Del-Ben et al 2005).…”

Section: Role Of 5-ht In Action Restraintmentioning

confidence: 99%

The neuropsychopharmacology of action inhibition: cross-species translation of the stop-signal and go/no-go tasks

2008

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Background and rationale The term 'action inhibition' encapsulates the ability to prevent any form of planned physical response. Growing evidence suggests that different 'stages' or even subtypes of action inhibition activate subtly different neuropharmacological and neuroanatomical processes. Objectives In this review, we present evidence from two commonly used and apparently similar behavioural tests, the stop-signal task and the go/no-go task, to determine if these have similar neuroanatomical and neurochemical modulation. Results Whilst performance of the stop-signal and go/no-go tasks is modulated across only subtly different anatomical networks, serotonin (5-HT) is strongly implicated in inhibitory control on the go/no-go but not the stop-signal task, whereas the stop-signal reaction time appears more sensitive to the action of noradrenaline. Conclusions There is clear neuropharmacological and neuroanatomical evidence that stop-signal and go/no-go tasks represent different forms of action inhibition. This evidence translates with remarkable consistency across species. We discuss the possible implications of this evidence with respect to the development of novel therapeutic treatments for disorders in which inhibitory deficits are prominent and debilitating.

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“…Thus, studies in rats and humans have shown that manipulating 5-HT does not affect performance on tasks of inhibition that have no clear affective component, such as the stop-signal reaction-time task Cools et al, 2005;Chamberlain et al, 2006;Bari et al, 2009;Eagle et al, 2009), the self-ordered spatial working memory task (Walker et al, 2009), and the go-nogo task (Rubia et al, 2005;Evers et al, 2006) (but see LeMarquand et al, 1999).…”

Section: The Coupling Between Inhibitory and Aversive Effects Of Seromentioning

confidence: 99%

Serotonin and Dopamine: Unifying Affective, Activational, and Decision Functions

Cools

Nakamura²,

Daw³

2010

Neuropsychopharmacol

408

369

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Serotonin, like dopamine (DA), has long been implicated in adaptive behavior, including decision making and reinforcement learning. However, although the two neuromodulators are tightly related and have a similar degree of functional importance, compared with DA, we have a much less specific understanding about the mechanisms by which serotonin affects behavior. Here, we draw on recent work on computational models of dopaminergic function to suggest a framework by which many of the seemingly diverse functions associated with both DA and serotoninFcomprising both affective and activational ones, as well as a number of other functions not overtly related to eitherFcan be seen as consequences of a single root mechanism.

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Tryptophan depletion reduces right inferior prefrontal activation during response inhibition in fast, event-related fMRI

Abstract: These findings provide neuro-functional evidence of a serotonergic modulation of right inferior prefrontal during inhibitory motor control. The increased engagement of temporal brain regions may reflect compensatory mechanisms.

Cited by 159 publications

References 111 publications

Assessment of Cognitive Brain Function in Ecstasy Users and Contributions of Other Drugs of Abuse: Results from an fMRI Study

Assessment of Cognitive Brain Function in Ecstasy Users and Contributions of Other Drugs of Abuse: Results from an fMRI Study

The neuropsychopharmacology of action inhibition: cross-species translation of the stop-signal and go/no-go tasks

Serotonin and Dopamine: Unifying Affective, Activational, and Decision Functions

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