Tuberculosis and Lipid Exchance

Kaminskaya, G. O.; Абдуллаев, Р. Ю.

doi:10.21292/2075-1230-2016-94-6-53-63

TaLD

2016

DOI: 10.21292/2075-1230-2016-94-6-53-63

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Tuberculosis and Lipid Exchance

G. O. Kaminskaya¹,

Р. Ю. Абдуллаев²

Abstract: Обзор включает 3 раздела. В первом разделе приведены современные представления о путях транспорта липидов в организме человека, о структурных и функциональных особенностях различных классов липопротеинов и об их роли в реализации адаптивных и патологиче ских процессов. Второй раздел включает современные данные о роли холестерина и в меньшей степени других липидов в персистировании и репликации микобактерий туберкулеза в организме человека. В третьем разделе представлена панорама разноплановых исследований обме… Show more

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Cited by 6 publications

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Vitamin D signal cascade in macrophages against <i>Mycobacterium tuberculosis</i>

Lavryashina

Imekina

Тхоренко

et al. 2023

Russian Journal of Infection and Immunity

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Mycobacterium tuberculosis is the causative agent of human tuberculosis; enabling multilayered mechanisms to evade from immune response along with reactivation of the process with subsequent pathogen dissemination. Modification of immune responses through imbalanced intracellular signaling pathways and reprogramming of differential gene expression is one of such mechanisms. Modification targets for M. tuberculosis are the genes which products are involved in lipid metabolism and apoptosis, a key to eliminate intracellular pathogens. here, we review the current scientific data related to this problem: the results of studies published in domestic and foreign literature from the years 2003 to 2022 were systematized and summarized; data on the role of a number of molecular mechanisms regulating lipid metabolism and apoptosis in human TB-infection; discuss contemporary ideas about the importance of the VDR signaling cascade controlled by the vitamin D-axis counteracting M. tuberculosis infection, its course and outcome. In addition, there are provided the data on the main M. tuberculosis genetic lines common in Siberia and the elements of the pathogen-related genetic structure that are important in the context of the topic. The effects of interplay and interactions of intracellular molecular cascades (VDR, NFKB, MAPK, NFAT5, AMPK, GR) are considered and analyzed, as well as their role in the differential expression of genes that ensure M. tuberculosis inactivation and elimination. Presenting the data confirming that one of the main strategies of mycobacterium immune evasion counteraction to apoptosis is implemented through altered VDR signaling pathway, including the epigenetic mechanisms occurring in the pathogen. Based on results of the analysis and summarized literature data (60 articles retrieved from eLIBRARY, PubMed), it is demonstrated that during the thousand-year history of co-evolution with human, M. tuberculosis acquired unique features of genetic organization and mastered the pathways of immune evasion using non-genomic and genomic mechanisms. Available publications confirm that one of the main strategies for M. tuberculosis survival in macrophages is to modify a balance between intracellular signaling cascades controlling the differential expression of genes that provide a proper immune response to infection, followed by pathogen elimination.

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Vitamin D signal cascade in macrophages against <i>Mycobacterium tuberculosis</i>

Lavryashina

Imekina

Тхоренко

et al. 2023

Russian Journal of Infection and Immunity

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Respiratory tuberculosis associated with chronic obstructive lung disease - actual problem of modern phthisiology

Katicheva¹,

Brazhenko²,

Brazhenko³

et al. 2020

Bulletin of the Russian Military Medical Academy

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In modern conditions, the problems of tuberculosis of the respiratory system and chronic obstructive pulmonary disease are highly relevant. Tuberculosis remains high among the population. During its course, the frequency of common destructive forms, the number of patients with multiple and extensive drug resistance of mycobacteria, and comorbid conditions in which pulmonary tuberculosis is combined with immunodeficiency and respiratory pathology increased. Chronic tobacco intoxication and chronic obstruction in the lungs increase the activity of tuberculosis inflammation, contribute to the development of common forms of pulmonary tuberculosis, accompanied by abundant bacterial excretion and destruction of lung tissue. In patients with comorbid pathology, pronounced clinical manifestations of the disease, deep functional disorders in the respiratory system and homeostatic balance of the organism are determined. Chronic tobacco intoxication and chronic obstruction in the bronchi have a significant impact on the processes of atherogenesis, systemic inflammation, endothelial dysfunction and the formation of cardiovascular pathology. These phenomena contribute to insufficient treatment efficiency, the formation of pronounced residual changes in the respiratory organs, a decrease in the quality and life expectancy of patients, a high frequency of exacerbation (relapse) and pose a threat to the spread of tuberculosis. In patients with comorbid pathology, cardiovascular complications, dyslipidemia and atherogenesis appear much more often, which are predictors of early disability and premature death.

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Effect of Glycyrrhizic Acid on the Membrane Structures of Mononuclear Cells in Pulmonary Tuberculosis Patients Receiving Anti-Tuberculosis Chemotherapy

Рясенский¹,

Aseev²,

Elgali³

2018

TIBL

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Цель исследования: оценить липидный спектр мембран мононуклеаров периферической крови у больных туберкулезом легких до и после интенсивной фазы химиотерапии, в том числе под влиянием препарата глицирризиновой кислоты (ГК)� Материалы и методы. В исследовании приняли участие 384 больных туберкулезом легких обоих полов в возрасте от 25 до 60 лет: 308 пациентов получили интенсивную фазу химиотерапии по первому режиму, 76-интенсивную фазу химиотерапии по первому режиму и курс препарата ГК� В группу контроля включено 36 здоровых добровольцев в возрасте от 24 до 58 лет� Определяли липидный спектр мембран мононуклеаров, полученных из периферической крови пациентов� Фракционирование фосфолипидов на классы выполняли посредством проточной тонкослойной хроматографии� Изучали следующие фракции: суммарные лизофосфолипиды, сфингомиелин, фосфатидилинозитол, фосфатидилхолин, фосфатидилсерин, фосфатидилэтаноламин� Результаты. У больных туберкулезом легких до начала химиотерапии зафиксировано изменение соотношения основных классов фосфолипидов мембран мононуклеаров периферической крови по сравнению со здоровыми лицами� Химиотерапия приводила к накоплению мембранодеструктивных лизофосфолипидов при одновременном снижении уровня фосфатидилхолина� Применение препарата ГК у пациентов позволило уменьшить (p < 0,05) негативное влияние химиотерапии на липидные мембраны мононуклеаров и нормализовать соотношение основных фракций фосфолипидов мембран (p < 0,05)� При химиотерапии с курсом препарата ГК увеличилась с 61 до 73% (p < 0,05) частота абациллирования мокроты к 2-месячному сроку интенсивной фазы химиотерапии� Ключевые слова: липидный спектр мембран, мононуклеары, глицирризиновая кислота, туберкулез Для цитирования: Рясенский Д� С�, Асеев А� В�, Эльгали А� И� Влияние глицирризиновой кислоты на состояние мембранных структур мононуклеаров у больных туберкулезом легких на фоне противотуберкулезной химиотерапии // Туберкулёз и болезни лёгких�-2018�-Т� 96, № 10�-С� 35-40�

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Tuberculosis and Lipid Exchance

Cited by 6 publications

References 2 publications

Vitamin D signal cascade in macrophages against <i>Mycobacterium tuberculosis</i>

Vitamin D signal cascade in macrophages against <i>Mycobacterium tuberculosis</i>

Respiratory tuberculosis associated with chronic obstructive lung disease - actual problem of modern phthisiology

Effect of Glycyrrhizic Acid on the Membrane Structures of Mononuclear Cells in Pulmonary Tuberculosis Patients Receiving Anti-Tuberculosis Chemotherapy

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