Tuberculosis Associated with HLA—B8, Bf S in a Newfoundland Community Study

Selby, Rita; Barnard, John M.; Buehler, Sharon; Crumley, J.; Larsen, Bodil; Marshall, William H.

doi:10.1111/j.1399-0039.1978.tb01275.x

Cited by 42 publications

(14 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The results of other studies contradict these findings [13]. These studies [6][7][8][9][10][11][12][13] indicate that susceptibility to TB is controlled, at least in part, by HLA or by other genes in the HLA region. Different associations are likely due to differences in race/ethnicity of the study populations, differences in study design, and epistasis-the interaction of 11 genein TB susceptibility.…”

mentioning

confidence: 71%

See 1 more Smart Citation

Mycobacterium tuberculosis/HIV‐1 Coinfection and Disease: Role of Human Leukocyte Antigen Variation

et al. 2004

View full text Add to dashboard Cite

Genetic variation influences immune responses and may contribute to differential development of tuberculosis (TB), particularly in immunosuppressed individuals. To examine the risk of Mycobacterium tuberculosis infection progressing to disease in the context of M. tuberculosis/human immunodeficiency virus (HIV) type 1 coinfection, HIV-1 RNA load and human leukocyte antigen (HLA) genotypes were determined among subjects from Harare, Zimbabwe, an area where both TB and HIV-1 are endemic. Patients with TB were compared with control subjects, stratified by HIV-1 infection status and progression of TB disease. Alleles of class I HLA-A and -C were associated with risk of developing active TB, depending on HIV-1 status. Among HIV-positive subjects, HIV-1 load was independently associated with increased risk of developing pulmonary TB. HLA DRB1 homozygosity among HIV-positive subjects was associated with reduced risk of developing pulmonary TB but increased risk of rapid progression to pleural effusion TB. These observations suggest that HLA plays a role in risk of developing symptomatic TB at various stages of disease and that these effects are modified by HIV-1 coinfection.

show abstract

mentioning

confidence: 71%

“…HLA-B8 was associated with increased risk for TB among white Canadians [6], whereas HLA-B15 played this role among African Americans [7]. In northern India, HLA-DR2 was associated with a marginal increase in risk of developing pulmonary TB (PTB), whereas HLA-DR6 was associated with a significant decrease in risk of developing PTB [8].…”

mentioning

confidence: 99%

Mycobacterium tuberculosis/HIV‐1 Coinfection and Disease: Role of Human Leukocyte Antigen Variation

et al. 2004

View full text Add to dashboard Cite

show abstract

“…Racial differences in susceptibility to TB are well known. Several studies have shown an association between various HLA antigens and disease susceptibility in different ethnic populations 12–17 . Hypotheses have been proposed to explain this geographic variation.…”

Section: Human Leucocyte Antigens and Tuberculosis Susceptibilitymentioning

confidence: 99%

Genetic susceptibility in tuberculosis

2010

View full text Add to dashboard Cite

The importance of host genetic factors in determining susceptibility to tuberculosis (TB) has been studied extensively using various methods, such as case-control, candidate gene and genome-wide linkage studies. Several important candidate genes like human leucocyte antigen/alleles and non-human leucocyte antigen genes, such as cytokines and their receptors, chemokines and their receptors, pattern recognition receptors (including toll-like receptors, mannose binding lectin and the dendritic cell-specific intercellular adhesion molecule-3 grabbing nonintegrin), solute carrier family 11A member 1 (formerly known as natural resistance-associated macrophage protein 1) and purinergic P2X7 receptor gene polymorphisms, have been associated with differential susceptibility to TB in various ethnic populations. This heterogeneity has been explained by host-pathogen and gene-environment interactions and evolutionary selection pressures. Although the achievements of genetics studies might not yet have advanced the prevention and treatment of TB, researchers have begun to widen their scope of investigation to encompass these practical considerations.

show abstract

“…It was observed that, there were increased familial aggregates of lymphomas and immunodeficiency in Newfoundland hence HLA typing was performed on 589 people. 2 Forty-six of them gave a past history of tuberculosis, which had required treatment. Fifty-six percent of the TB patients carried HLA B8 compared with 20% of the remainder of the population ðp , 0:01Þ revealing a possible link between TB and coeliac disease.…”

Section: Discussionmentioning

confidence: 99%