Tucumã oil (Astrocaryum vulgare) ameliorates hepatic antioxidant defense system in alloxan-induced diabetic mice

Abstract

The aim of this study was to investigate whether treatment with Astrocaryum vulgare oil (tucumã oil), a hypoglycemic natural compound, was able to reduce hepatic oxidative stress of diabetic mice. An increase in lipid peroxidation and decrease in catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), and glutathione S-transferase (GST) activities, as well as glutathione reductase (GSH) levels were observed in diabetic/water group. Treatment with tucumã oil prevented lipid peroxidation and inhibition of CAT and SOD activities in diabetic mice. The tucumã oil treatment may provide effective protection against lipid oxidative damage in the liver tissue of diabetic mice, since it improved the enzymatic antioxidant defense system. Therefore, the tucumã oil can be an important coadjutant in the treatment of diabetes, contributing to the prevention and reduction of oxidative damage. Practical applicationsRecently, it was demonstrated that tucumã oil exerts potent antihyperglycemic effect in alloxaninduced diabetic mice. The oil improved the pancreatic oxidant/antioxidant status, playing an essential role in the hypoglycemic effect. The results showed that tucumã oil can reduce oxidative stress in liver tissue, and consequently, prevent the hepatic alterations caused by high glucose levels. K E Y W O R D Santioxidant, catalase, glucose, lipid peroxidation, liver

Emerging Lipids from Arecaceae Palm Fruits in Brazil

“…Another study also showed that TPP oil might prevent changes in serum enzymes of the purinergic system, resulting in an improvement of the immune system [196]. Furthermore, TPP oil showed its effectiveness in the hepatoprotection against lipid oxidative damage and in the prevention of lipid peroxidation in hepatic tissue [197]. Antihyperglycemic and antioxidant activities in alloxan-induced diabetic mice were also reported [160].…”

Propriedades e potencialidades de fontes amazônicas oleaginosas: tucumã e pracaxi

“…Testes in vivo e in vitro foram realizados no óleo da polpa de tucumã (Tabela 4), os estudam demostraram indicação para tratamento de hiperglicemia, assim como melhoria no sistema de defesa antioxidante hepática e no sistema imunológico (Baldissera., et al 2017a;Baldissera., et al 2017b;Baldissera., et al 2018) Carotenoides a…”

“…In vivo Processo tóxico (H) Ácido beénico e compostos fenólicos Fonte: (A) ; (B) ( Baldissera., et al, 2018); (C) ; (D) (Rossato et al, 2019); (E) (Hovorková, Laloučková, Skřivanová, 2018); (F) à sua composição química que inclui vários tipos de moléculas de polifenóis e ácidos graxos (Rossato et al, 2019). Em outro estudo mostra que esse óleo foi eficaz contra ambas as cepas de E. cecorum, duas cepas de C. perfringens e S. aureus (Hovorková, Laloučková, Skřivanová 2018).…”

“…Entre as matrizes estão o tucumã (Astrocaryum vulgare Mart.,) e o pracaxi (Pentaclethra macroloba) que são espécies com potencial oleaginosa encontrada na Amazônia, o óleo extraído desses frutos são de suma importância por serem fontes de ácidos graxos (AG) ω6 e ω9 que são benéficos à saúde (Rodrigues, Darnet, & Silva, 2010), além disso, essas oleaginosas são excelentes fontes de compostos bioativos com destaque para ß-caroteno encontrado no óleo de tucumã, e vitamina E total encontrada no óleo de pracaxi (Santos et al, 2015;Serra et al, 2019;De Souza et a., 2023). Diversos estudos, in vivo e in vitro dessas matrizes são relatadas na literatura com ação antimicrobiana, antiproliferativo, anti-hiperglicêmicas e antioxidantes Baldissera et al, 2018, Rossato et al, 2019Nascimento et al,2021), mostrando o potencial desses óleos.…”

Effect of extraction type on the fatty acids profile and physicochemical properties of biolipids from Astrocaryum vulgare pulp: supercritical CO2 versus n‐hexane extractions

“…Carotenoids are known as lipophilic substances with bioactive properties in the prevention of several types of cancer (Rowles and Erdman, 2020). Other studies investigated the constituents and health effects of oil and extracts of tucumã, demonstrating its antimicrobial and anti‐inflammatory properties (Baldissera et al ., 2018; Cabral et al ., 2020; Ongaratto et al ., 2020; Rossato et al ., 2020). These findings highlight the potential benefic effects on human health and nutrition by the intake of tucumã fruit and its oil.…”