Tumor-Associated Alterations in Caspase-14 Expression in Epithelial Malignancies

Krajewska, Maryla; Kim, Hoguen; Shin, Eunah; Kennedy, Susan; Duffy, Michael J.; Wong, Yick Fu; Marr, David G.; Mikolajczyk, Jowita; Shabaik, Ahmed; Meinhold‐Heerlein, Ivo; Huang, Xianshu; Banares, Steven; Hedayat, Hirad; Reed, John C.; Krajewski, Stan

doi:10.1158/1078-0432.ccr-04-2527

Cited by 59 publications

(59 citation statements)

References 33 publications

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“…The tissues were prepared for paraffin embedding, as described elsewhere (17). TMAs were produced for all investigated tumors and tissues, as described previously (14).…”

Section: Methodsmentioning

confidence: 99%

Bcl-B Expression in Human Epithelial and Nonepithelial Malignancies

Krajewska

Kitada

Winter

et al. 2008

Clinical Cancer Research

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Purpose: Apoptosis plays an important role in neoplastic processes. Bcl-B is an antiapoptotic Bcl-2 family member, which is known to change its phenotype upon binding to Nur77/TR3. The expression pattern of this protein in human malignancies has not been reported. Experimental Design: We investigated Bcl-B expression in normal human tissues and several types of human epithelial and nonepithelial malignancy by immunohistochemistry, correlating results with tumor stage, histologic grade, and patient survival. Results: Bcl-B protein was strongly expressed in all normal plasma cells but found in only 18% of multiple myelomas (n = 133). Bcl-B immunostaining was also present in normal germinal center centroblasts and centrocytes and in approximately half of diffuse large B-cell lymphoma (n = 48) specimens, whereas follicular lymphomas (n = 57) did not contain Bcl-B. In breast (n = 119), prostate (n = 66), gastric (n = 180), and colorectal (n = 106) adenocarcinomas, as well as in non^small cell lung cancers (n = 82), tumor-specific overexpression of Bcl-B was observed. Bcl-B expression was associated with variables of poor prognosis, such as high tumor grade in breast cancer (P = 0.009), microsatellite stability (P = 0.0002), and left-sided anatomic location (P = 0.02) of colorectal cancers, as well as with greater incidence of death from prostate cancer (P = 0.005) and shorter survival of patients with small cell lung cancer (P = 0.009). Conversely, although overexpressed in many gastric cancers, Bcl-B tended to correlate with better outcome (P = 0.01) and more differentiated tumor histology (P < 0.0001).Conclusions: Tumor-specific alterations in Bcl-B expression may define subsets of nonepithelial and epithelial neoplasms with distinct clinical behaviors.

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“…The tissues were prepared for paraffin embedding, as described elsewhere (17). TMAs were produced for all investigated tumors and tissues, as described previously (14).…”

Section: Methodsmentioning

confidence: 99%

Bcl-B Expression in Human Epithelial and Nonepithelial Malignancies

Krajewska

Kitada

Winter

et al. 2008

Clinical Cancer Research

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“…Expression of caspase-14 is reduced in the colon, cervical and ovarian tumor tissue and associated with more advanced-stage cancers. 183 However, ductal carcinomas showed increased caspase-14 levels compared to surrounding mammary tissue. 183 Caspase-14 overexpression in a human salivary gland adenocarcinoma has been shown to promote growth inhibition and prevent tumorigenicity in athymic mice.…”

Section: Caspases In Tumorigenesismentioning

confidence: 99%

“…183 However, ductal carcinomas showed increased caspase-14 levels compared to surrounding mammary tissue. 183 Caspase-14 overexpression in a human salivary gland adenocarcinoma has been shown to promote growth inhibition and prevent tumorigenicity in athymic mice. 184 New functions for old molecules S Shalini et al…”

Section: Caspases In Tumorigenesismentioning

confidence: 99%

Old, new and emerging functions of caspases

et al. 2014

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Caspases are proteases with a well-defined role in apoptosis. However, increasing evidence indicates multiple functions of caspases outside apoptosis. Caspase-1 and caspase-11 have roles in inflammation and mediating inflammatory cell death by pyroptosis. Similarly, caspase-8 has dual role in cell death, mediating both receptor-mediated apoptosis and in its absence, necroptosis. Caspase-8 also functions in maintenance and homeostasis of the adult T-cell population. Caspase-3 has important roles in tissue differentiation, regeneration and neural development in ways that are distinct and do not involve any apoptotic activity. Several other caspases have demonstrated anti-tumor roles. Notable among them are caspase-2, -8 and -14. However, increased caspase-2 and -8 expression in certain types of tumor has also been linked to promoting tumorigenesis. Increased levels of caspase-3 in tumor cells causes apoptosis and secretion of paracrine factors that promotes compensatory proliferation in surrounding normal tissues, tumor cell repopulation and presents a barrier for effective therapeutic strategies. Besides this caspase-2 has emerged as a unique caspase with potential roles in maintaining genomic stability, metabolism, autophagy and aging. The present review focuses on some of these less studied and emerging functions of mammalian caspases.

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“…Interestingly, knockout of casp-14 gene increases epidermal storage of profilaggrin and sensitivity to ultraviolet (UV) B, suggesting that casp-14 plays a role in protein maturation of filaggrin (16), and possibly in DNA repair. overexpression of casp-14 has been detected in several of epithelial malignancies, indicating that casp-14 could play a role in carcinogenesis and disease progression of cancers (17,18). However, casp-14 has not been studied in lung adenocarcinomas, of which the incidence and mortality have increased dramatically in the last two decades in taiwan (19).…”

Section: Caspase-14 Is An Anti-apoptotic Protein Targeting Apoptosis-mentioning

confidence: 99%

“…nuclear presence of these proteins increases genomic instability as well as resistance to irradiation and anticancer drugs (29, 31), suggesting that the nuclear presence of these proteins is vital for cell survival. nuclear casp-14 has been detected in the stratum spinosum of normal skin, psoriatic lesions and epithelial malignancies (17,18,22). However, casp-14 is not detected in basal and cornified layers of normal skin or in basal layer and parakeratotic abrasion of psoriasis.…”

Section: D1 D2 Ementioning

confidence: 99%

Caspase-14 is an anti-apoptotic protein targeting apoptosis-inducing factor in lung adenocarcinomas

Chow

2011

Oncol Rep

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Using apoptosis-inducing factor protein as bait in a yeast hybrid assay to screen protein libraries, we identified three proteins that interacted with apoptosis-inducing factor: human homolog of yeast Rad23 protein A (hHR23A), microsomal glutathione S-transferase and caspase-14 (casp-14). In this study, we investigated the expression and function of casp-14 in lung adenocarcinomas (LADC). Our results showed that monoclonal antibodies were specific to casp-14, and that casp-14 was highly expressed in LADC. Casp-14 overexpression correlated with tumor stage, cell differentiation and lymphovascular involvement, suggesting that casp-14 was associated with tumor cell growth and metastatic potential. In vitro, casp-14 interacted with apoptosis-inducing factor, and silencing of casp-14 expression reduced cisplatin resistance. Our data suggest that casp-14 is an anti-apoptotic protein targeting apoptosis-inducing factor and increases cisplatin resistance in LADC cells

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Tumor-Associated Alterations in Caspase-14 Expression in Epithelial Malignancies

Cited by 59 publications

References 33 publications

Bcl-B Expression in Human Epithelial and Nonepithelial Malignancies

Bcl-B Expression in Human Epithelial and Nonepithelial Malignancies

Old, new and emerging functions of caspases

Caspase-14 is an anti-apoptotic protein targeting apoptosis-inducing factor in lung adenocarcinomas

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